Abstract
To study the association between the 3′UTR single nucleotide polymorphism of PSD95 gene and the risk of acute ischemic stroke (AIS) in Chinese Han population. PSD95 gene 3′UTR rs191350575, rs314254, rs58197058, rs314253, rs314252, rs188777, rs11652753, rs79715480, and rs13331 genotypes of a total of 280 AIS patients and 280 healthy controls were analyzed. The prognosis outcomes of all AIS patients were analyzed after 3 years of follow-up. The risk of AIS in the rs58197058 locus A allele was 1.76 times higher than the G allele (95%CI 1.53–1.92, p < 0.01). The rs314252 locus A allele carrier was 1.29 times more likely to develop AIS than the G allele (95%CI 1.14–1.45, p < 0.01). The rs13331 locus A allele was a high-risk factor for ASI (adjusted OR = 1.18, 95%CI 1.05–1.33, p = 0.01). The interaction model between Alcohol, DM, Hypertension, rs58197058, and rs314252 predicted the highest accuracy of AIS, with a corresponding sensitivity of 75.36%, specificity of 85.00%, and cross-validation consistency (CVC) of 10/10 (p < 0.01). There was a significant correlation between rs58197058, rs314252, and rs13331 SNPs and plasma FG, TC, HDL-c, and LDL-c levels in AIS patients. The PSD95 gene 3′UTR rs58197058, rs314252, and rs13331 SNPs are associated with the occurrence and prognosis of Chinese Han AIS patients.
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This work is supported by grants from the Natural Science Foundation of China (81771258, 81771131) and the Shanghai Science and Technology Committee Project (17411950100, 17411950101).
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This study was reviewed and approved by the Ethics Review Committee at Shanghai Tenth People’ s Hospital (ethical code number: SHSY-IEC-3.0/15-5-01) and was performed in accordance with Declaration of Helsinki. All subjects provided their informed consent in writing prior to their participation in the study.
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Lin, YY., Yu, Ty., Quan, H. et al. Association Between PSD95 Gene 3′UTR Single Nucleotide Polymorphism and Risk of Acute Ischemic Stroke in Chinese Han Population. J Mol Neurosci 70, 1389–1402 (2020). https://doi.org/10.1007/s12031-020-01559-y
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DOI: https://doi.org/10.1007/s12031-020-01559-y