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Genetic Evidence for the Involvement of Variants at APOE, BIN1, CR1, and PICALM Loci in Risk of Late-Onset Alzheimer’s Disease and Evaluation for Interactions with APOE Genotypes

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Abstract

Alzheimer’s disease (AD) is the most common form of dementia in older population. Growing evidence of genetic background that predisposes individuals to AD has been reported as the risk factors in recent years. The Department of Medical Genetics and the Immunology Research Centre investigated the distribution of 11 polymorphisms in 160 patients with late onset AD (LOAD) and in 163 healthy controls, using the sequencing technique. All participants were of Turkish Azeri ethnicity. We compared allele and genotype frequencies between the LOAD patients and control subjects using a chi-square or Fisher’s exact test. Alleles and genotypes of APOE, PICALM rs3851179 and rs541458, and the BIN1 gene rs744373 polymorphism were significantly different between LOAD and control groups. The frequencies of the other investigated alleles were similar in the two groups. We also analyzed the association of BIN1, CR1 and PICALM SNPs with LOAD in subgroups stratified by the presence or absence of the APOE ε4 allele. After adjusting for APOE, statistical analysis revealed that the association with PICALM rs541458 and BIN1 rs744373 were only significant among subjects without the APOE ε4 allele.

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Authors and Affiliations

  1. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Jalal Gharesouran

  2. Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

    Jalal Gharesouran, Maryam Rezazadeh & Aziz Khorrami

  3. Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran

    Maryam Rezazadeh

  4. Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Morteza Ghojazadeh

  5. Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Mahnaz Talebi

Authors
  1. Jalal Gharesouran
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  2. Maryam Rezazadeh
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  3. Aziz Khorrami
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  4. Morteza Ghojazadeh
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  5. Mahnaz Talebi
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Correspondence to Jalal Gharesouran.

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Jalal Gharesouran and Maryam Rezazadeh have equal contribution.

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Gharesouran, J., Rezazadeh, M., Khorrami, A. et al. Genetic Evidence for the Involvement of Variants at APOE, BIN1, CR1, and PICALM Loci in Risk of Late-Onset Alzheimer’s Disease and Evaluation for Interactions with APOE Genotypes. J Mol Neurosci 54, 780–786 (2014). https://doi.org/10.1007/s12031-014-0377-5

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  • DOI: https://doi.org/10.1007/s12031-014-0377-5

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