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Frontotemporal Dementia: From Mendelian Genetics Towards Genome Wide Association Studies

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Abstract

Frontotemporal lobar degeneration is the most common cause of dementia of non-Alzheimer's type worldwide. It manifests, clinically, with behavioural changes and language impairment and is pathologically associated with tau- or ubiquitin-positive inclusions detected in neurons and glial cells of the frontal and temporal lobes in the brain. Genetic variations in the microtubule-associated protein tau and progranulin genes explain almost 50% of familial cases, whilst variations in TAR DNA-binding protein, charged multivescicular body protein 2B, valosin-containing protein and fused in sarcoma genes contribute to <5% of cases. The rapidly developing investigative techniques available to geneticists such as genome-wide association studies, whole-exome sequencing and, soon, whole-genome sequencing promise to contribute to the unravelling of the genetic architecture of this complex disease and, in the future, to the development of more sensitive, accurate and effective diagnostic and treatment measures.

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Authors and Affiliations

  1. Department of Internal Medicine, Texas Tech University Health Sciences Center, 3601 4th St. STOP 9410, Lubbock, TX, 79430, USA

    Raffaele Ferrari & Parastoo Momeni

  2. Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, UCL, 9th Floor, Queen Square House, Queen Square, London, WC1N 3BG, UK

    Raffaele Ferrari & John Hardy

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  1. Raffaele Ferrari
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  2. John Hardy
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  3. Parastoo Momeni
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Correspondence to Raffaele Ferrari.

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Ferrari, R., Hardy, J. & Momeni, P. Frontotemporal Dementia: From Mendelian Genetics Towards Genome Wide Association Studies. J Mol Neurosci 45, 500–515 (2011). https://doi.org/10.1007/s12031-011-9635-y

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