Abstract
The 32-kDa dopamine- and cAMP-regulated phosphoprotein (DARPP-32) is a key signaling factor in several neurotransmitter pathways (including dopamine and serotonin) that impact personality traits. Therefore, different DARPP-32 alleles may influence the biological determination of distinct personality types. We established an association between the DARPP-32 gene polymorphisms (rs12601930C/T, rs879606A/G, and rs3764352A/G) and personality traits as measured by the Tridimensional Personality Questionnaire in 502 healthy Chinese-Han subjects. Of the three polymorphic sites examined, rs12601930C/T was associated with novelty seeking (χ 2 = 13.06, P = 0.001), while both rs879606A/G and rs3764352A/G were associated with harm avoidance (rs879606: χ 2 = 7.74, P = 0.021; rs3764352: χ 2 = 8.53, P = 0.014). There was no significant association between reward dependence scores and DARPP-32 gene polymorphisms. Our results suggest that polymorphisms in the DARPP-32 gene are involved in the biological mechanisms that confer the traits of novelty seeking and harm avoidance.
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Abbreviations
- TPQ:
-
Tridimensional Personality Questionnaire
- NS:
-
Novelty seeking
- HA:
-
Harm avoidance
- RD:
-
Reward dependence
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Acknowledgments
This study was supported by a Grant from National Natural Science Foundation of China (30400146).
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Jingying Li and Huan Ma contributed equally to this work.
An erratum to this article is available at http://dx.doi.org/10.1007/s12031-013-0055-z.
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Li, J., Ma, H., Zhou, H. et al. Association Between DARPP-32 Gene Polymorphism and Personality Traits in Healthy Chinese-Han Subjects. J Mol Neurosci 44, 48–52 (2011). https://doi.org/10.1007/s12031-011-9505-7
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DOI: https://doi.org/10.1007/s12031-011-9505-7