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Cumulative Evidence for Association Between IL-8 -251T>A and IL-18 -607C>A Polymorphisms and Colorectal Cancer Susceptibility: a Systematic Review and Meta-analysis

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Abstract

Purpose

The correlation of IL-8 and IL-18 gene polymorphisms with colorectal cancer (CRC) was investigated by previous studies, though the results remained conflicting. Thus, the meta-analysis was performed to investigate the association of IL-8 -251T>A and IL-18 -607C>A polymorphisms with CRC risk.

Methods

A comprehensive search of the PubMed, Web of Science, CNKI, SciELO, and Wanfang databases was performed up to February 20, 2020. The strength of the associations was calculated with odds ratios (ORs) and their corresponding 95% of confidence intervals (CIs).

Results

A total of 16 case-control studies including 13 studies with 3908 cases and 5005 controls on IL-8 -251T>A polymorphism and three studies with 396 cases and 560 controls on IL-18 -607C>A polymorphism were selected. Pooled data revealed that the IL-8 -251T>A and IL-18 -607C>A polymorphisms were not significantly associated with an increased risk of CRC in global population. When stratified by ethnicity, source of controls, sample size, and Hardy-Weinberg equilibrium (HWE), there were still no significant association between IL-8 -251T>A polymorphism and risk of CRC.

Conclusions

Our results revealed that the IL-8 -251T>A and IL-18 -607C>A polymorphisms were not associated with an increased susceptibility to CRC. We strongly call for further studies with larger sample sizes and different ethnicities to confirm our findings.

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Acknowledgments

We would like to express our sincere gratitude to Professor Seyed Mehdi Kalantar for his motivation, knowledge, and support during the course of this research.

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Authors and Affiliations

  1. Department of Internal Medicine, Yazd Branch, Islamic Azad University, Yazd, Iran

    Mohammad Hossein Antikchi

  2. Department of Medical Laboratory Sciences, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran

    Fatemeh Asadian

  3. Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

    Seyed Alireza Dastgheib

  4. Clinical Research Development Center of Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Yaser Ghelmani

  5. Department of Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Shadi Kargar

  6. Department of Food Science and Technology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Jalal Sadeghizadeh-Yazdi

  7. Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Hossein Neamatzadeh

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  1. Mohammad Hossein Antikchi
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Contributions

M.H.A and F.A are responsible as the guarantor of integrity of the entire study, study design and concepts, definition of intellectual content, and literature research. H.N, Y.G, and S.K. are responsible for the clinical studies, experimental studies, data acquisition, and manuscript preparation. S.A.D and H.N are responsible for the data analysis, statistical analysis, and manuscript review. J.S.Y is responsible for the manuscript editing. All authors have read and agreed with the final version of this manuscript.

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Correspondence to Fatemeh Asadian.

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Antikchi, M.H., Asadian, F., Dastgheib, S.A. et al. Cumulative Evidence for Association Between IL-8 -251T>A and IL-18 -607C>A Polymorphisms and Colorectal Cancer Susceptibility: a Systematic Review and Meta-analysis. J Gastrointest Canc 52, 31–40 (2021). https://doi.org/10.1007/s12029-020-00521-w

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