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A Multinational Assessment of Gastric, Esophageal, and Colorectal Cancer Burden: A Report of Disease Incidence, Prevalence, and Fatality

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Abstract

Introduction

Digestive cancers, including colorectal, stomach, and esophageal cancer, represent one-third of all new cancer cases in the world. This comprehensive analysis seeks to summarize the burden of digestive system cancers on a global scale, within specific countries in the Americas, Europe, Asia, Oceania, and Africa.

Methods

Burden is measured using prevalence, incidence, and case-fatality rates. Estimates of incidence rates and case-fatality ratios were further stratified by gender and age group (< 65 years and ≥ 65 years).

Results

In general, these data highlight differences in the prevalence and incidence of gastric, esophageal, and colorectal cancers by gender and region. Large variations in case-fatality rates by gender and age are also present.

Conclusions

These data illustrate the worldwide burden of digestive diseases and may help guide resource allocation to decrease the impact of digestive cancers around the world.

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Acknowledgments

The authors would like to thank and acknowledge the following people for their contributions to this article: Human Identity for graphics support. Support for this assistance was funded by Amgen, Inc.

Funding

This research project was funded by Amgen, Inc. Amgen was involved in the study design, data collection and analysis, decision to publish, and preparation of the manuscript. All authors had full access to all of the data in this study and take complete responsibility for the integrity of the data and accuracy of the data analysis. The article processing charges were funded by Amgen, Inc. Individual conflict of interest disclosures are given below:

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Authors and Affiliations

  1. University of Arizona, Tucson, AZ, USA

    Ana Florea

  2. SimulStat, Portland, OR, USA

    Laura Sangaré

  3. Amgen, Inc., One Amgen Center Drive Mailstop D2262, Thousand Oaks, CA, 91320, USA

    Kimberly Lowe

Authors
  1. Ana Florea
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  2. Laura Sangaré
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  3. Kimberly Lowe
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Corresponding author

Correspondence to Kimberly Lowe.

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Conflict of Interest

AF was an intern at Amgen at the time this research was conducted. KL is an employee of Amgen, Inc. and owns stock in Amgen, Inc. LS is employed by SimulStat, work contracted through Amgen, Inc.

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Florea, A., Sangaré, L. & Lowe, K. A Multinational Assessment of Gastric, Esophageal, and Colorectal Cancer Burden: A Report of Disease Incidence, Prevalence, and Fatality. J Gastrointest Canc 51, 965–971 (2020). https://doi.org/10.1007/s12029-019-00328-4

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  • DOI: https://doi.org/10.1007/s12029-019-00328-4

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