Skip to main content

Advertisement

SpringerLink
Log in

Three Cases of Serous Oligocystic Adenomas of the Pancreas; Evaluation of Cyst Wall Thickness for Preoperative Differentiation from Mucinous Cystic Neoplasms

  • Published:
Journal of Gastrointestinal Cancer Aims and scope Submit manuscript

Abstract

Background

Serous oligocystic adenoma (SOA), a rare pancreatic neoplasm, is generally a benign lesion without the necessity of surgery. Preoperatively, it is difficult to discriminate SOA from mucinous cystic neoplasm (MCN), which essentially needs surgical treatment. The purpose of this study was to evaluate the cyst wall thickness of SOAs and MCNs for preoperative differential diagnosis.

Methods

We experienced three cases of SOAs with typical histopathological features. The cyst wall thickness of the SOAs was evaluated in the area protruding out of the pancreas and was compared with that of 13 MCNs histopathologically. The same evaluation and comparison were conducted on preoperative computed tomography (CT) images retrospectively.

Results

The SOAs had a uniformly thin cyst wall measuring less than 1 mm. In contrast, the largest area of a cyst wall in MCNs ranged from 2.5 to 10.0 mm. On CT images, all but one of the MCNs showed a detectable cyst wall, while the cyst walls were hardly recognizable in two of the three SOAs.

Conclusions

For preoperative differentiation between SOAs and MCNs, the evaluation of cyst wall thickness may be an important tool and may contribute to the decision of treatment strategy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Compagno J, Oertel JE. Microcystic adenomas of the pancreas (glycogen-rich cystadenomas): A clinicopathologic study of 34 cases. Am J Clin Pathol 1978;69:289–98.

    PubMed  CAS  Google Scholar 

  2. Compagno J, Oertel JE. Mucinous cystic neoplasms of the pancreas with overt and latent malignancy (cystadenocarcinoma and cystadenoma). A clinicopathologic study of 41 cases. Am J Clin Pathol 1978;69:573–80.

    PubMed  CAS  Google Scholar 

  3. Lewandrowski K, Warshaw A, Compton C. Macrocystic serous cystadenoma of the pancreas: A morphologic variant differing from microcystic adenoma. Hum Pathol 1992;23:871–5.

    Article  PubMed  CAS  Google Scholar 

  4. Goh BK, Tan YM, Yap WM, Cheow PC, Chow PK, Chung YF, Wong WK, Ooi LL. Pancreatic serous oligocystic adenomas: Clinicopathologic features and a comparison with serous microcystic adenomas and mucinous cystic neoplasms. World J Surg 2006;30:1553–9.

    Article  PubMed  Google Scholar 

  5. Sperti C, Pasquali C, Perasole A, Liessi G, Pedrazzoli S. Macrocystic serous cystadenoma of the pancreas: Clinicopathologic features in seven cases. Int J Pancreatol 2000;28:1–7.

    PubMed  CAS  Google Scholar 

  6. Chatelain D, Hammel P, O’Toole D, Terris B, Vilgrain V, Palazzo L, Belghiti J, Levy P, Ruszniewski P, Flejou JF. Macrocystic form of serous pancreatic cystadenoma. Am J Gastroenterol 2002;97:2566–71.

    Article  PubMed  Google Scholar 

  7. Cunha JE, Perini MV, Siqueira SA, Jukemura J, Penteado S, Machado MC, Abdo EE, Montagnini AL. Serous oligocystic adenoma of the pancreas. Pancreatology 2003;3:482–6.

    Article  PubMed  Google Scholar 

  8. Egawa N, Maillet B, Schroder S, Mukai K, Kloppel G. Serous oligocystic and ill-demarcated adenoma of the pancreas: A variant of serous cystic adenoma. Virchows Arch 1994;424:13–7.

    Article  PubMed  CAS  Google Scholar 

  9. Fujiwara H, Ajiki T, Fukuoka K, Mitsutsuji M, Yamamoto M, Kuroda Y. Macrocystic serous cystadenoma of the pancreas. J Hepatobiliary Pancreat Surg 2000;7:92–6.

    Article  PubMed  CAS  Google Scholar 

  10. Gouhiri M, Soyer P, Barbagelatta M, Rymer R. Macrocystic serous cystadenoma of the pancreas: CT and endosonographic features. Abdom Imaging 1999;24:72–4.

    Article  PubMed  CAS  Google Scholar 

  11. Kaneto H, Endo T, Ozeki I, Itoh H, Sasaki S, Mukaiya M, Ikeda K, Koito K, Imai K. Macrocystic serous cystadenoma of the pancreas: Importance of co-existent tiny cysts depicted by EUS. J Gastroenterol 2000;35:472–5.

    Article  PubMed  CAS  Google Scholar 

  12. Sakata K, Maeda Y, Harada T, Nagashima J, Ueda M, Shimabukuro T, Sugano M, Nishizawa H, Fukuyama N, Kawashima M, Noguchi T, Iida Y, Yokota T. A serous oligocystic adenoma of the head of the pancreas successfully treated by dome resection and chemocautery: A new approach to serous oligocystic adenoma. J Hepatobiliary Pancreat Surg 2003;10:446–9.

    Article  PubMed  Google Scholar 

  13. Santos LD, Chow C, Henderson CJ, Blomberg DN, Merrett ND, Kennerson AR, Killingsworth MC. Serous oligocystic adenoma of the pancreas: A clinicopathological and immunohistochemical study of three cases with ultrastructural findings. Pathology 2002;34:148–56.

    Article  PubMed  Google Scholar 

  14. Capella C, Solcia E, Klöppel G, Hruban RH. Serous cystic neoplasms of the pancreas. In: Hamilton SR, Aaltonen LA, editors. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System. Lyon, France: IARC Press; 2000. p. 237–40.

    Google Scholar 

  15. Solcia E, Capella C, Klöppel G. Atlas of Tumor Pathology: Tumors of the Pancreas, 3rd Series Fascicle 20. Washington, DC: Armed Forces Institute of Pathology; 1997.

    Google Scholar 

  16. Kamei K, Funabiki T, Ochiai M, Amano H, Kasahara M, Sakamoto T. Multifocal pancreatic serous cystadenoma with atypical cells and focal perineural invasion. Int J Pancreatol 1991;10:161–72.

    Article  PubMed  CAS  Google Scholar 

  17. George DH, Murphy F, Michalski R, Ulmer BG. Serous cystadenocarcinoma of the pancreas: A new entity? Am J Surg Pathol 1989;13:61–6.

    Article  PubMed  CAS  Google Scholar 

  18. Friebe V, Keck T, Mattern D, Schmitt-Graeff A, Werner M, Mikami Y, Adam U, Hopt UT. Serous cystadenocarcinoma of the pancreas: Management of a rare entity. Pancreas 2005;31:182–7.

    Article  PubMed  Google Scholar 

  19. Eriguchi N, Aoyagi S, Nakayama T, Hara M, Miyazaki T, Kutami R, Jimi A. Serous cystadenocarcinoma of the pancreas with liver metastases. J Hepatobiliary Pancreat Surg 1998;5:467–70.

    Article  PubMed  CAS  Google Scholar 

  20. Ishikawa T, Nakao A, Nomoto S, Hosono J, Harada A, Nonami T, Takagi H. Immunohistochemical and molecular biological studies of serous cystadenoma of the pancreas. Pancreas 1998;16:40–4.

    Article  PubMed  CAS  Google Scholar 

  21. Matsumoto T, Hirano S, Yada K, Shibata K, Sasaki A, Kamimura T, Ohta M, Kitano S, Kashima K. Malignant serous cystic neoplasm of the pancreas: Report of a case and review of the literature. J Clin Gastroenterol 2005;39:253–6.

    Article  PubMed  Google Scholar 

  22. Ohta T, Nagakawa T, Itoh H, Fonseca L, Miyazaki I, Terada T. A case of serous cystadenoma of the pancreas with focal malignant changes. Int J Pancreatol 1993;14:283–9.

    PubMed  CAS  Google Scholar 

  23. Yoshimi N, Sugie S, Tanaka T, Aijin W, Bunai Y, Tatematsu A, Okada T, Mori H. A rare case of serous cystadenocarcinoma of the pancreas. Cancer 1992;69:2449–53.

    Article  PubMed  CAS  Google Scholar 

  24. Widmaier U, Mattfeldt T, Siech M, Beger HG. Serous cystadenocarcinoma of the pancreas. Int J Pancreatol 1996;20:135–9.

    PubMed  CAS  Google Scholar 

  25. Shintaku M, Arimoto A, Sakita N. Serous cystadenocarcinoma of the pancreas. Pathol Int 2005;55:436–9.

    Article  PubMed  Google Scholar 

  26. Tanaka M, Chari S, Adsay V, Fernandez-del Castillo C, Falconi M, Shimizu M, Yamaguchi K, Yamao K, Matsuno S. International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas. Pancreatology 2006;6:17–32.

    Article  PubMed  Google Scholar 

  27. Perez-Ordonez B, Naseem A, Lieberman PH, Klimstra DS. Solid serous adenoma of the pancreas. The solid variant of serous cystadenoma? Am J Surg Pathol 1996;20:1401–5.

    Article  PubMed  CAS  Google Scholar 

  28. Compton CC. Serous cystic tumors of the pancreas. Semin Diagn Pathol 2000;17:43–55.

    PubMed  CAS  Google Scholar 

  29. Khurana B, Mortele KJ, Glickman J, Silverman SG, Ros PR. Macrocystic serous adenoma of the pancreas: Radiologic-pathologic correlation. AJR Am J Roentgenol 2003;181:119–23.

    PubMed  Google Scholar 

  30. Takeshita K, Kutomi K, Takada K, Kohtake H, Furui S, Takada T, Fukushima J. Unusual imaging appearances of pancreatic serous cystadenoma: Correlation with surgery and pathologic analysis. Abdom Imaging 2005;30:610–15.

    Article  PubMed  CAS  Google Scholar 

  31. Cohen-Scali F, Vilgrain V, Brancatelli G, Hammel P, Vullierme MP, Sauvanet A, Menu Y. Discrimination of unilocular macrocystic serous cystadenoma from pancreatic pseudocyst and mucinous cystadenoma with CT: Initial observations. Radiology 2003;228:727–33.

    Article  PubMed  Google Scholar 

  32. O’Toole D, Palazzo L, Hammel P, Ben Yaghlene L, Couvelard A, Felce-Dachez M, Fabre M, Dancour A, Aubert A, Sauvanet A, Maire F, Levy P, Ruszniewski P. Macrocystic pancreatic cystadenoma: The role of EUS and cyst fluid analysis in distinguishing mucinous and serous lesions. Gastrointest Endosc 2004;59:823–9.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Hiroshi Yamaguchi, Takahiro Inoue, Takashi Eguchi, Shigenori Nagata, Yosuke Kuroda, Yunosuke Nishihara & Masazumi Tsuneyoshi

  2. Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Kousei Ishigami

  3. Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Koji Yamaguchi & Masao Tanaka

  4. Department of Pathology, Saitama Medical University International Medical Center, Saitama, Japan

    Hiroshi Yamaguchi

Authors
  1. Hiroshi Yamaguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kousei Ishigami
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Takahiro Inoue
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Takashi Eguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Shigenori Nagata
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yosuke Kuroda
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yunosuke Nishihara
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Koji Yamaguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Masao Tanaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Masazumi Tsuneyoshi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hiroshi Yamaguchi.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yamaguchi, H., Ishigami, K., Inoue, T. et al. Three Cases of Serous Oligocystic Adenomas of the Pancreas; Evaluation of Cyst Wall Thickness for Preoperative Differentiation from Mucinous Cystic Neoplasms. J Gastrointest Canc 38, 52–58 (2007). https://doi.org/10.1007/s12029-008-9017-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12029-008-9017-z

Keywords

Search

Navigation