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Low Triglyceride Levels are Associated with Unfavorable Outcomes in Patients with Spontaneous Intracerebral Hemorrhage

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Abstract

Background and Aims

The relationship between serum lipid level and clinical outcome after spontaneous intracerebral hemorrhage (ICH) remains controversial. We sought to evaluate the association of serum lipid levels with clinical outcomes in patients with ICH.

Methods

Data on consecutive patients hospitalized with spontaneous ICH were prospectively collected from May 2005 to May 2018 and retrospectively analyzed. Following clinical and demographic data, age and gender, risk factors, serum lipid levels [total cholesterol, triglycerides (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) cholesterol] and the outcomes were analyzed.

Results

A total of 1451 patients with ICH (mean age, 60.41 ± 12.3 years; 32.6% women) was evaluated. Although admission TG levels were associated with the outcomes at hospital discharge and 3 months in initial univariate analyses, the former association did not retain its statistical significance in multivariate logistic regression analyses adjusting for potential confounders. However, lower admission TG levels were independently associated (p = 0.045) with a higher likelihood of 12-month unfavorable outcomes (odds ratio 0.91, 95% confidence interval 0.83–0.99) in multivariate logistic regression models.

Conclusions

Low TG levels at hospital admission were an independent predictor for unfavorable long-term outcomes in patients with spontaneous ICH. The exact mechanisms of the association need further investigations.

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Authors and Affiliations

  1. Department of Neurology, Tianjin Huanhu Hospital, Tianjin, 300350, China

    Qian Liu, Wenjuan Zhao, Yonghong Xing, Yan Hong & Guanen Zhou

  2. Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Disease, Tianjin, 300350, China

    Qian Liu, Wenjuan Zhao, Yonghong Xing, Yan Hong & Guanen Zhou

Authors
  1. Qian Liu
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  2. Wenjuan Zhao
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  3. Yonghong Xing
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  4. Yan Hong
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  5. Guanen Zhou
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Contributions

QL: study concept and design, acquisition of data, analysis and interpretation, writing of the manuscript, critical revision of the manuscript for important intellectual content; WJZ, YH, YHX: analysis and interpretation, critical revision of the manuscript for important intellectual content; GEZ: study concept and design, analysis and interpretation, critical revision of the manuscript for important intellectual content.

Corresponding author

Correspondence to Guanen Zhou.

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The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Ethical Approval/Informed Consent

The study protocol was approved by the Ethics Committee for Medical Research at Tianjin Huanhu Hospital, and each participant recruited to the study provided informed consent.

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Liu, Q., Zhao, W., Xing, Y. et al. Low Triglyceride Levels are Associated with Unfavorable Outcomes in Patients with Spontaneous Intracerebral Hemorrhage. Neurocrit Care 34, 218–226 (2021). https://doi.org/10.1007/s12028-020-01023-0

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  • DOI: https://doi.org/10.1007/s12028-020-01023-0

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