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Hypothermia After CPR Prolongs Conduction Times of Somatosensory Evoked Potentials

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Abstract

Background

To investigate the effect of mild hypothermia on conduction times and amplitudes of median nerve somatosensory evoked potentials (SEP) in patients after cardiopulmonary resuscitation (CPR).

Methods

Patients treated with hypothermia after CPR who underwent SEP recording during hypothermia and after rewarming were selected from a prospectively collected database. Latencies and amplitudes of N9 (peripheral conduction time, PCT), N13, and N20 were measured. The central conduction time (CCT) was defined as peak–peak latency N13–N20. Recordings of 25 patients were assessed by a second observer to determine the intraclass correlation coefficient (ICC).

Results

A total of 115 patients were included. The mean body temperature at SEP during hypothermia was 33.1 °C (SD 0.8) and after rewarming 37.1 °C (SD 0.8). Mean latencies of N9, N13, and N20 and mean CCT were longer during hypothermia. There were no consistent differences in amplitudes. There was an almost perfect ICC for assessment of latencies and amplitudes.

Conclusions

This study showed that PCT and CCT of median nerve SEP were prolonged during treatment with hypothermia after CPR compared with after rewarming. Amplitudes did not differ consistently.

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Acknowledgments

The authors would like to thank Jan Binnekade for help with statistical analysis and Thijs Boeree for creation of Fig. 1.

Conflict of interest

This study was supported by research grants from The Netherlands Brain Foundation, 14F06.48, and the Dutch Heart Foundation, 2007B039. Dr. Bouwes, Ms. Doesborg, Dr. Laman, Dr. Koelman, Dr. Imanse, Dr. Tromp, Dr. van Geel, Dr. van der Kooi, and Dr. Zandbergen report no conflict of interest. Dr. Horn has received research grants from The Netherlands Brain Foundation (14F06.48) and from the Dutch Heart Foundation (2007B039).

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Authors and Affiliations

  1. Department of Intensive Care, Room C3-423, Academic Medical Center, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands

    Aline Bouwes, Patty G. G. Doesborg & Janneke Horn

  2. Department of Neurology and Clinical Neurophysiology, Sint Lucas Andreas Hospital, P.O. Box 9243, 1006 AE, Amsterdam, The Netherlands

    D. Martin Laman

  3. Departments of Neurology and Clinical Neurophysiology, Academic Medical Center, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands

    Johannes H. T. M. Koelman

  4. Department of Neurology, Onze Lieve Vrouwe Gasthuis, P.O. Box 95500, 1090 HM, Amsterdam, The Netherlands

    Jaap G. Imanse

  5. Department of Clinical Neurophysiology, St. Antonius Hospital, P.O. Box 2500, 3430 EM, Nieuwegein, The Netherlands

    Selma C. Tromp

  6. Department of Neurology, Medical Center Alkmaar, P.O. Box 501, 1800 AM, Alkmaar, The Netherlands

    Björn M. van Geel

  7. Department of Neurology, Medical Center Leeuwarden, P.O. Box 888, 8901 BR, Leeuwarden, The Netherlands

    Elly L. van der Kooi

  8. Department of Neurology, Rijnstate Hospital, P.O. Box 9555, 6800 TA, Arnhem, The Netherlands

    Eveline G. J. Zandbergen

Authors
  1. Aline Bouwes
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  2. Patty G. G. Doesborg
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  3. D. Martin Laman
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  4. Johannes H. T. M. Koelman
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  5. Jaap G. Imanse
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  6. Selma C. Tromp
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  7. Björn M. van Geel
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  8. Elly L. van der Kooi
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  9. Eveline G. J. Zandbergen
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  10. Janneke Horn
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Corresponding author

Correspondence to Aline Bouwes.

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Bouwes, A., Doesborg, P.G.G., Laman, D.M. et al. Hypothermia After CPR Prolongs Conduction Times of Somatosensory Evoked Potentials. Neurocrit Care 19, 25–30 (2013). https://doi.org/10.1007/s12028-013-9856-8

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  • DOI: https://doi.org/10.1007/s12028-013-9856-8

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