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Transdisciplinary approach to restore pancreatic islet function

  • Immunology & Microbiology in Miami
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Abstract

The focus of our research is on islet immunobiology. We are exploring novel strategies that could be of assistance in the treatment and prevention of type 1 diabetes, as well as in the restoration of metabolic control via transplantation of insulin producing cells (i.e., islet cells). The multiple facets of diabetes and β-cell replacement encompass different complementary disciplines, such as immunology, cell biology, pharmacology, and bioengineering, among others. Through their interaction and integration, a transdisciplinary dimension is needed in order to address and overcome all aspects of the complex puzzle toward a successful clinical translation of a biological cure for diabetes.

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Acknowledgments

We are grateful to the faculty and staff at the Diabetes Research Institute (www.DiabetesResearch.org) and to the collaborators from multiple national and international institutions, including the members of the Diabetes Research Institute Federation (/www.diabetesresearch.org/DRI-Federation-Members?) and of The Cure Alliance (www.TheCureAlliance.org) contributing to our transdisciplinary research team endeavors. The work discussed herein is integral part of the Diabetes Research Institute’s BioHub© Mini Organ Program. Invaluable assistance was obtained through the Diabetes Research Institute’s Cores (Preclinical Cell Processing & Translational Models, Human cGMP Cell Processing, Imaging, Flow Cytometry, Histology, and Administrative) and through the University of Miami Division of Veterinary Resources and the DNA Core for Bioluminiscence Imaging. Procedures involving animals were performed under protocols approved and monitored by the University of Miami IACUC under an Animal Welfare Assurance on file (A-3224-01, effective 12/4/02) with the Office of Laboratory Animal Welfare (OLAW), National Institutes of Health, and full accreditation by the Association for Assessment and Accreditation of Laboratory Animal Care. The biohybrid device was designed and manufactured by Biorep, Inc. (Miami, FL). Human islets were obtained through NIH-NCRR Islet Cell Resources (ICR) and subsequently from the Integrated Islet Distribution Program (IIDP). This work was supported in part by grants from the American Diabetes Association (7-13-IN-32; to A.P.), the Juvenile Diabetes Research Foundation International (17-2012-361, 17-2010-5, 4-2008-811, 4-2004-361, to C.R. and A.P.), The Leona M. and Harry B. Helmsley Charitable Trust, the National Institutes of Health (5U19AI050864-10 to A.P.; U01DK089538 to A.P.; 5U42RR016603-08S1 to C.R.; 1U01DK70460-02 to C.R.; 5R01DK25802-24 to C.R.; 5R01DK56953-05 to C.R.), the University of Miami Interdisciplinary Research Development Initiative (A.P.), and the Diabetes Research Institute Foundation (to A.P., C.R.), and Converge Biotech (A.P. and C.R.). Notably, the funding agencies had no role in the design and conduct of the study, collection, management, analysis and interpretation of the data, content, presentation, decision to publish, or preparation of the manuscript.

Conflict of interest

C.F., R.D.M., C.R. and A.P. own intellectual property that may be related to the topic discussed in this article. A.P. and C.R. are members of the scientific advisory board; and A.P., R.D.M., and C.R. are stock option holders in Converge Biotech, licensee of some of the intellectual property that may be related to the topic discussed in this article.

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Authors and Affiliations

  1. Cell Transplant Center, Diabetes Research Institute, University of Miami, Miami, FL, USA

    Carmen Fotino, R. Damaris Molano, Camillo Ricordi & Antonello Pileggi

  2. DeWitt-Daughtry Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA

    Camillo Ricordi & Antonello Pileggi

  3. Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, USA

    Camillo Ricordi & Antonello Pileggi

  4. Department of Biomedical Engineering, University of Miami, Miami, FL, USA

    Camillo Ricordi & Antonello Pileggi

  5. Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA

    Camillo Ricordi

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  1. Carmen Fotino
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Correspondence to Antonello Pileggi.

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Fotino, C., Molano, R.D., Ricordi, C. et al. Transdisciplinary approach to restore pancreatic islet function. Immunol Res 57, 210–221 (2013). https://doi.org/10.1007/s12026-013-8437-4

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