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Cell Transplantation Therapy for Diabetes Mellitus: From Embryonic Stem Cells to Transdifferentiation of Adult Cells

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Stem Cells: Basics and Clinical Translation

Part of the book series: Translational Medicine Research ((TRAMERE,volume 1))

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Abstract

Pancreatic transplant and islet cell transplantation are alternative procedure to “cure” diabetes. The last one has already become an accepted practice to stabilize frequent hypoglycemia or severe glycemic lability in highly selected subjects with poor glycemic control. Advancements during the last decade in the fields of regenerative medicine, tissue engineering, immunomodulatory therapy, and gene therapy have drawn us a step closer to making the application of stem cell therapy a feasible reality in the cure of diabetes. However, a combinatorial approach that can combine safe and effective stem cell strategies with reliable existing therapies such as islet transplantation, as well as the latest immunosuppressive and immunomodulatory drug regimens and/or novel bioengineering techniques, would ensure an optimistic scenario for successful translation of stem cell therapy in the cure of diabetes. In short, the application of stem cell therapy in the cure for diabetes appears extremely promising, with bona fide hope for a permanent cure.

The two authors contributed equally to this work.

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Authors and Affiliations

  1. Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Diabetes Research Center of Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China

    Xinhua Xiao

  2. Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, 100029, China

    Yijing Liu

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  1. Xinhua Xiao
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  2. Yijing Liu
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Correspondence to Xinhua Xiao .

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  1. Center of Excellence in Tissue Engineeri, Institute of Basic Medical Sciences School of Basic Medicine, Beijing, China

    Robert Chunhua Zhao

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Xiao, X., Liu, Y. (2015). Cell Transplantation Therapy for Diabetes Mellitus: From Embryonic Stem Cells to Transdifferentiation of Adult Cells. In: Zhao, R. (eds) Stem Cells: Basics and Clinical Translation. Translational Medicine Research, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-7273-0_21

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