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Th1 or Th2 balance regulated by interaction between dendritic cells and NKT cells

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Abstract

If Th1 or Th2 polarization could be artificially manipulated, effective immune responses would be generated depending on nature of the targets. In this study we attempted to regulate CD40 expressions on dendritic cells (DCs) in order to modify the T cell response. It was found that reducing agents selectively inhibited surface expression of CD40 on DCs. This finding may provide a new strategy of DC-mediated modulation of the Th1/Th2 balance. It was also shown that NKT-produced Th1/Th2 cytokine balance was under control of negative feedback loop through DCs. Th1 cytokine-pretreated DCs mainly induced Th2 cytokine production, whereas Th2 cytokine-pretreated DCs induced Th1 cytokine production by α-galactosylceramide-stimulated NKT cells. The negative feedback regulation system could be applicable to therapeutics of various diseases based on immunological disorders.

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Acknowledgments

We are grateful to Ms. Sayaka Yagi and Ms. Mayumi Kondo for their secretarial assistance. This study was supported by a Grant-in-Aid for Scientific Research (S), (C), a Grant-in-Aid for Exploratory Research, and a Grant-in-Aid for Young Scientists (B) from JSPS and a Grant-in-Aid for Scientific Research on Priority Areas by the MEXT Japan. This study was also supported by the Uehara Memorial Life Science Foundation, Akiyam Memorial Foundation, Suhara Memorial Foundation, and Tamakomai East Hospital Foundation.

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Authors and Affiliations

  1. Division of Immunobiology, Institute for Genetic Medicine, Hokkaido University, Kita-ku, Kita-15, Nishi-7, Sapporo, 060-0815, Japan

    Kazunori Onoé, Yoshiki Yanagawa, Keita Minami, Norifumi Iijima & Kazuya Iwabuchi

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  1. Kazunori Onoé
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  2. Yoshiki Yanagawa
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  3. Keita Minami
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  4. Norifumi Iijima
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  5. Kazuya Iwabuchi
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Correspondence to Kazunori Onoé.

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Presented at the First Robert A Good Society Symposium, St. Petersburg, FL 2006.

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Onoé, K., Yanagawa, Y., Minami, K. et al. Th1 or Th2 balance regulated by interaction between dendritic cells and NKT cells. Immunol Res 38, 319–332 (2007). https://doi.org/10.1007/s12026-007-0011-5

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