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Riedel’s thyroiditis: report of 7 patients and review of literature

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Abstract

Riedel’s thyroiditis is a rare inflammatory-sclerosing thyroid disease, and its aetiology remains unknown. After a surgical biopsy to establish the diagnosis, the treatment of Riedel’s thyroiditis is still challenging in most patients. The aim of this article is to report seven patients with Riedel’s thyroiditis seen in a department of Endocrinology and Metabolic diseases over a period of 24 years, and based on the patient’s data and the review of the literature to discuss the indications of surgery, glucocorticoids, tamoxifen and immunosuppressive drugs in the personalized treatment of patients with Riedel’s thyroiditis.

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References

  1. I.D. Hay, Thyroiditis: a clinical update. Mayo Clin. Proc. 60(1), 61–63 (1985). https://doi.org/10.1016/s0025-6196(12)65287-2

    Article  CAS  PubMed  Google Scholar 

  2. J.V. Hennessey, Clinical review: Riedel’s thyroiditis: a clinical review. J. Clin. Endocrinol. Metab. 96(10), 3031–3041 (2011). https://doi.org/10.1210/jc.2011-0617

    Article  CAS  PubMed  Google Scholar 

  3. H. Falhammar, C. Juhlin, C. Barner, S.B. Catrina, C. Karefylakis, J. Calissendorff, Riedel’s thyroiditis: clinical presentation, treatment and outcomes. Endocrine 60(1), 185–192 (2018). https://doi.org/10.1007/s12020-018-1526-3

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. A. Zala, T. Berhane, C.C. Juhlin, J. Calissendorff, H. Falhammar, Riedel thyroiditis. J. Clin. Endocrinol. Metab. 105(9), dgaa468 (2020). https://doi.org/10.1210/clinem/dgaa468

    Article  PubMed  Google Scholar 

  5. A.A. Shafi, N.B. Saad, B. AlHarthi, Riedel’s thyroiditis as a diagnostic dilemma - a case report and review of the literature. Ann. Med. Surg. 52, 5–9 (2020). https://doi.org/10.1016/j.amsu.2020.02.006

    Article  Google Scholar 

  6. R. Pandev, M. Khan, V. Ratheesh, Riedel’s thyroiditis: pitfalls in diagnosis and subsequent complications. Case Rep. Endocrinol. 2023, 9989953 (2023). https://doi.org/10.1155/2023/9989953

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. M.M. Fatourechi, I.D. Hay, B. McIver, T.J. Sebo, V. Fatourechi, Invasive fibrous thyroiditis (Riedel thyroiditis): the Mayo Clinic experience, 1976-2008. Thyroid 21(7), 765–772 (2011). https://doi.org/10.1089/thy.2010.0453

    Article  PubMed  Google Scholar 

  8. J.C. Lo, K.C. Loh, A.L. Rubin, I. Cha, F.S. Greenspan, Riedel’s thyroiditis presenting with hypothyroidism and hypoparathyroidism: dramatic response to glucocorticoid and thyroxine therapy. Clin. Endocrinol. 48(6), 815–818 (1998). https://doi.org/10.1046/j.1365-2265.1998.00449.x

    Article  CAS  Google Scholar 

  9. A. Gökçay Canpolat, M. Cinel, S. Dizbay Sak, I. Taşkaldıran, H. Korkmaz, Ö. Demir, R. Ersoy, S. Dağdelen, D. Berker, K. Dalva, A.B. Bahçecioğlu Mutlu, M.F. Erdoğan, Long-term outcomes of tamoxifen citrate therapy and histo- and immunopathological properties in Riedel thyroiditis. Eur. Thyroid J. 10(3), 248–256 (2021). https://doi.org/10.1159/000512017

    Article  CAS  PubMed  Google Scholar 

  10. S. Fontaine, F. Gaches, L. Lamant, M. Uzan, A. Bennet, P. Caron, An unusual form of Riedel’s thyroiditis: a case report and review of the literature. Thyroid 15(1), 85–88 (2005). https://doi.org/10.1089/thy.2005.15.85

    Article  CAS  PubMed  Google Scholar 

  11. A. Dupret-Bories, P. Caron, I. Rouquette, B. Vairel, S. Vergez, Fatal neck necrotizing cellulitis in a patient with Riedel’s thyroiditis. Thyroid 23(7), 904–905 (2013). https://doi.org/10.1089/thy.2012.0569

    Article  PubMed  Google Scholar 

  12. P. Majety, J.V. Hennessey, Acute and Subacute, and Riedel’s Thyroiditis. In: Feingold KR, Anawalt B, Blackman MR, et al., editors. Endotext [Internet]. (MDText.com, Inc., South Dartmouth (MA), 2022)

  13. A. Torres-Montaner, M. Beltrán, A. Romero de la Osa, H. Oliva, Sarcoma of the thyroid region mimicking Riedel’s thyroiditis. J. Clin. Pathol. 54(7), 570–572 (2001). https://doi.org/10.1136/jcp.54.7.570

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. A. Ozgen, A. Cila, Riedel’s thyroiditis in multifocal fibrosclerosis: CT and MR imaging findings. AJNR Am. J. Neuroradiol. 21, 320–321 (2000)

    CAS  PubMed  PubMed Central  Google Scholar 

  15. M. Dahlgren, A. Khosroshahi, G.P. Nielsen, V. Deshpande, J.H. Stone, Riedel’s thyroiditis and multifocal fibrosclerosis are part of the IgG4-related systemic disease spectrum. Arthritis Care Res. 62(9), 1312–1318 (2010). https://doi.org/10.1002/acr.20215

    Article  Google Scholar 

  16. A. Czarnywojtek, K. Pietrończyk, L.D.R. Thompson, A. Triantafyllou, E. Florek, N. Sawicka-Gutaj, M. Ruchała, M.T. Płazinska, I.J. Nixon, A.R. Shaha, M. Zafereo, G.W. Randolph, P. Angelos, A. Al Ghuzlan, A. Agaimy, A. Ferlito, IgG4-related sclerosing thyroiditis (Riedel-Struma): a review of clinicopathological features and management. Virchows Arch. 483(2), 133–144 (2023). https://doi.org/10.1007/s00428-023-03561-2

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. K. Takeshima, H. Inaba, H. Ariyasu, Y. Furukawa, A. Doi, M. Nishi, M. Hirokawa, A. Yoshida, R. Imai, T. Akamizu, Clinicopathological features of Riedel’s thyroiditis associated with IgG4-related disease in Japan. Endocr. J. 62(8), 725–731 (2015). https://doi.org/10.1507/endocrj.EJ15-0175

    Article  CAS  PubMed  Google Scholar 

  18. O. Drieskens, D. Blockmans, A. Van den Bruel, L. Mortelmans, Riedel’s thyroiditis and retroperitoneal fibrosis in multifocal fibrosclerosis, positron emission tomographic findings. Clin. Nucl. Med. 27(6), 413–415 (2002). https://doi.org/10.1097/00003072-200206000-00005

    Article  PubMed  Google Scholar 

  19. P. Kotilainen, L. Airas, T. Kojo, T. Kurki, K. Kataja, H. Minn, P. Nuutila, Positron emission tomography as an aid in the diagnosis and follow-up of Riedel’s thyroiditis. Eur. J. Intern. Med. 15(3), 186–189 (2004). https://doi.org/10.1016/j.ejim.2004.03.002

    Article  PubMed  Google Scholar 

  20. R. Slman, H. Monpeyssen, S. Desarnaud, J. Haroche, L.P. Fediaevsky, M. Fabrice, D. Seret-Begue, Z. Amoura, A. Aurengo, L. Leenhardt, Ultrasound, elastography, and fluorodeoxyglucose positron emission tomography/computed tomography imaging in Riedel’s thyroiditis: report of two cases. Thyroid 21(7), 799–804 (2011). https://doi.org/10.1089/thy.2010.0242

    Article  PubMed  Google Scholar 

  21. R. Mansberg, R. Bency, L. Shen, C. Bui, K. Park, Riedel’s thyroiditis with intense FDG uptake demonstrated on FDG PET/CT. Mol. Imaging Radionucl. Ther. 24(1), 29–31 (2015). https://doi.org/10.4274/mirt.98598

    Article  PubMed  PubMed Central  Google Scholar 

  22. D. Kottahachchi, D.J. Topliss, Immunoglobulin G4-related thyroid diseases. Eur. Thyroid J. 5(4), 231–239 (2016). https://doi.org/10.1159/000452623

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. K. Pritchyk, K. Newkirk, P. Garlich, Z. Deeb, Tamoxifen therapy for Riedel’s thyroiditis. Laryngoscope 114(10), 1758–1760 (2004). https://doi.org/10.1097/00005537-200410000-00015

    Article  PubMed  Google Scholar 

  24. S.B. Soh, A. Pham, R.E. O’Hehir, M. Cherk, D.J. Topliss, Novel use of rituximab in a case of Riedel’s thyroiditis refractory to glucocorticoids and tamoxifen. J. Clin. Endocrinol. Metab. 98(9), 3543–3549 (2013). https://doi.org/10.1210/jc.2012-4050

    Article  CAS  PubMed  Google Scholar 

  25. L. Hunt, B. Harrison, M. Bull, T. Stephenson, A. Allahabadia, Rituximab: a novel treatment for refractory Riedel’s thyroiditis. Endocrinol. Diabetes Metabol Case Rep. 2018, 17–0132 (2018). https://doi.org/10.1530/EDM-17-0132

    Article  Google Scholar 

  26. S.V. Mammen, M.B. Gordon, Successful use of rituximab in a case of Riedel thyroiditis resistant to treatment with prednisone and tamoxifen. AACE Clin. Case Rep. 5(3), e218–e221 (2019). https://doi.org/10.4158/ACCR-2018-0352

    Article  PubMed  PubMed Central  Google Scholar 

  27. J.M. Levy, C.P. Hasney, P.L. Friedlander, E. Kandil, E.A. Occhipinti, M.J. Kahn, Combined mycophenolate mofetil and prednisone therapy in tamoxifen- and prednisone-resistant Reidel’s thyroiditis. Thyroid 20(1), 105–107 (2010). https://doi.org/10.1089/thy.2009.0324

    Article  CAS  PubMed  Google Scholar 

  28. A. Lawless, A. Papachristos, B. Robinson, S. Sidhu, T. Eade, Refractory Riedel’s thyroiditis managed with low dose radiotherapy. Rep. Pract. Oncol. Radiother. 27(3), 591–592 (2022). https://doi.org/10.5603/RPOR.a2022.0033

    Article  PubMed  PubMed Central  Google Scholar 

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  1. Department of Endocrinology, Metabolic Diseases and Nutrition, Cardiovascular and Metabolic Unit, CHU Larrey, Toulouse, France

    Philippe Caron

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Caron, P. Riedel’s thyroiditis: report of 7 patients and review of literature. Endocrine (2024). https://doi.org/10.1007/s12020-024-03853-w

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