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Serum 25 hydroxyvitamin D concentrations in individuals over 80 years old and their correlations with musculoskeletal and health parameters

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Abstract

Purpose

The present study aims to evaluate the serum concentrations of 25 hydroxyvitamin D[25(OH)D] in individuals aged ≥80 years, independent, free-living in Sao Paulo, Brazil (Lat 23.5 oS), and to investigate their associations with musculoskeletal system, physical performance and health markers.

Method

This cross-sectional study included 212 community dwellers aged ≥80 years and evaluated serum 25(OH)D, PTH, calcium, albumin, phosphorus, creatinine, bone markers, and bone mineral density. Physical performance was evaluated with stationary march, Flamingo, and functional reach tests, questionnaires to assess falls and fractures in the previous year, energy expenditure (MET), and Charlson index. Physical activity was evaluated with the International Physical Activity Questionnaire.

Results

Vitamin D deficiency (<20 ng/mL) was observed in 56% and severe vitamin D deficiency (<10 ng/mL) in 13% of those individuals. Serum concentrations of 25(OH)D were significantly and positively associated with BMD total hip (p = 0.001), femoral neck (p = 0.011) and 33% radius (p = 0.046) BMDs, MET (p = 0.03) and functional reach test (p = 0.037) and negatively with age (p = 0.021), PTH (p = 0.004) and osteoporosis diagnosis (p = 0.012). Long-lived individuals with 25(OH)D ≥ 20 ng/mL had higher total hip and femoral neck BMDs (p = 0.012 and p = 0.014, respectively) and lower PTH (p = 0.030). In multiple linear regression analysis, age and osteoporosis diagnosis remained negatively associated with 25(OH)D levels (p = 0.021 and p = 0.001, respectively), while corrected calcium and cholecalciferol use remained positively associated (p = 0.001 and p = 0.024, respectively).

Conclusion

We observed high vitamin D inadequacy prevalence in those Brazilian community dwellers’ oldest old. Serum concentrations of 25(OH)D were positively associated with bone mass and dynamic balance, and negatively with PTH and osteoporosis diagnosis. Additionally, 25(OH)D ≥ 20 ng/mL was associated with better bone mass and lower PTH levels.

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Acknowledgements

We thank CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior) for the support to our post-graduation research Brazilian program. We also thank Dr Livia Marcela Santos for her valuable contribution in data analysis.

Funding

This study was funded by the Foundation for Research Support of the State of São Paulo–FAPESP (2011/12753-8).

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Authors and Affiliations

  1. Division of Endocrinology, Escola Paulista de Medicina—Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil

    Mariana Zuccolotto Foroni, Eliane Naomi Sakane, Rosangela Villa Marin-Mio, Sergio Setsuo Maeda & Marise Lazaretti-Castro

  2. Division of Geriatrics, Escola Paulista de Medicina—Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil

    Maysa Seabra Cendoroglo & Patricia Ferreira do Prado Moreira

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Contributions

M.Z.F.: conceptualization, data curation, formal analysis, funding acquisition, investigation, methodology, project administration, visualization, writing, review and editing, seen and approved the final version. M.S.C.: conceptualization, data curation, formal analysis, funding acquisition, investigation, methodology, project administration, resources, supervision, writing, review and editing, seen and approved the final version. E.N.S.: formal analysis, investigation, methodology, visualization, writing, review and editing, seen and approved the final version. R.V.M.M.: formal analysis, investigation, methodology, review and editing, seen and approved the final version. P.F.P.M.: formal analysis, investigation, methodology, seen and approved the final version. S.S.M.: conceptualization, formal analysis, investigation, methodology, visualization, writing, review and editing, seen and approved the final version. M.L.C.: conceptualization, formal analysis, funding acquisition, investigation, methodology, project administration, supervision, writing, review and editing, seen and approved the final version.

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Foroni, M.Z., Cendoroglo, M.S., Sakane, E.N. et al. Serum 25 hydroxyvitamin D concentrations in individuals over 80 years old and their correlations with musculoskeletal and health parameters. Endocrine 79, 559–570 (2023). https://doi.org/10.1007/s12020-022-03231-4

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