Skip to main content
Log in

Inherited thyroid tumours

  • Original Article
  • Published:
Endocrine Aims and scope Submit manuscript

Abstract

Inherited thyroid tumours are an important group which need clarification. This is partly because of the common use of the term Familial Non-Medullary Thyroid Cancer when some of the specific entities included under this heading really represent inherited benign tumours with a risk of progression to malignancy. The subject is briefly reviewed, and one syndromic and one non-syndromic type of inherited thyroid tumours of follicular cell origin discussed in more detail to emphasise the point that each of these groups need to be treated as separate entities.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. E.D. Williams, C.L. Brown, I. Doniach, Pathological and clinical findings in a series of 67 cases of medullary carcinoma of the thyroid. J. Clin. Path. 19, 103–113 (1966)

    Article  CAS  Google Scholar 

  2. E.D. Williams, Histogenesis of medullary carcinoma of the thyroid. J. Clin. Path. 19, 114–118 (1966)

    Article  CAS  Google Scholar 

  3. Y.S. Peiling, J. Ngeow, Familial non-medullary thyroid cancer: unravelling the genetic maze. Endocr. Relat. Cancer 23, R577–R595 (2016)

    Article  Google Scholar 

  4. K. Hincza, A. Kowalik, A. Kowalska, Current knowledge of germline genetic risk factors for the development of non-medullary thyroid cancer. Genes 10, E482 (2019). https://doi.org/10.3390/genes10070482

    Article  CAS  PubMed  Google Scholar 

  5. L. Curtis, A.H. Wyllie, J.J. Shaw et al. Evidence against involvement of APC mutation in papillary thyroid cancer. Eur. J. Cancer 30A, 984–987 (1994)

    Article  CAS  Google Scholar 

  6. H.R. Harach, G.T. Williams, E.D. Williams, Familial adenomatous polyposis associated thyroid carcinoma: a distinct type of follicular cell neoplasm. Histopathology 25, 549–561 (1994)

    Article  CAS  Google Scholar 

  7. M. Miyaki, T. Iijima, R. Ishii et al. Molecular evidence for multicentric development of thyroid carcinoma in patients with familial adenomatous polyposis. Am. J. Pathol. 157, 1825–1827 (2000)

    Article  CAS  Google Scholar 

  8. M. De Felice, R. Di Lauro, Thyroid development and its disorders: genetics and molecular mechanisms. Endocr. Rev. 25, 722–746 (2004)

    Article  Google Scholar 

  9. M. Nilsson, H. Fagman, Development of the thyroid gland. Development 44, 2123–2140 (2017)

    Article  Google Scholar 

  10. B. Xu, K. Yoshimoto, A. Miyauchi et al. Cribriform morular variant of papillary thyroid carcinoma. J. Pathol. 199, 58–67 (2003)

    Article  Google Scholar 

  11. F. Cetta, G. Chiappetta, R.M. Melillo et al. The ret/ptc1 oncogene is activated in familial adenomatous associated thyroid papillary carcinoma. J. Clin. Endocrinol. Metab. 83, 1003–1006 (1998)

    CAS  PubMed  Google Scholar 

  12. A. Bakhsh, G. Kirov, J.W. Gregory et al. A new form of familial multinodular goitre with progression to differentiated thyroid cancer. Endocr. Relat. Cancer 13, 475–483 (2006)

    Article  CAS  Google Scholar 

  13. A.D. Bakhsh, I. Ladas, M.L. Hamshere et al. An indel in phospholipase-C-B-1 is linked with euthyroid multinodular goitre. Thyroid 28, 891–901 (2018)

    Article  CAS  Google Scholar 

Download references

Acknowledgements

Thanks are due to Helen Bardwell for technical help and to the estate of the late Mr John Williams for financial support.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Dillwyn Williams.

Ethics declarations

Conflict of interest

The author declares no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Williams, D. Inherited thyroid tumours. Endocrine 68, 271–273 (2020). https://doi.org/10.1007/s12020-020-02252-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12020-020-02252-1

Navigation