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Genetic variants in ADIPOQ gene and the risk of type 2 diabetes: a case–control study of Chinese Han population

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Abstract

This study was to evaluate the association between ADIPOQ gene variants and type 2 diabetes mellitus (T2DM). TaqMan® assay was performed to test the genotypes in T2DM patients (n = 1,105) and normal control subjects (n = 1,107). Serum adiponectin concentration was measured by ELISA kit. The variant genotypes rs7649121AT and rs7649121AT/TT, compared with the AA genotype, were associated with a significantly decreased risk of T2DM [Adjusted OR (95% CI) = 0.79(0.66–0.95), 0.80(0.67–0.96), respectively]. In stratified analysis, rs2241767AG genotype increased the risk of T2DM in obesity group [Adjusted OR (95% CI) = 1.32(1.03–1.69)]. Patients with genotype AG/GG of rs2241767 had lower levels of serum adiponectin than those with the genotype AA (P = 0.044). Haplotype analyses were not significant. Crossover analysis of rs7649121 and environmental risk factor (obesity) indicated that the protect effect of rs7649121AT/TT maybe offset by the environmental risk. Those who exposed to environmental risk factor (obesity) had a chance to attack T2DM compared with those who did not expose to the two factors [Adjusted OR (95% CI) = 1.64(1.30–2.06)]. This study suggested that the ADIPOQ gene polymorphisms were associated with the risk of T2DM in a Chinese Han population.

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Acknowledgments

We would like to thank National Natural Science Foundation of China Grant 30771858 and Jiangsu Provincial Natural Science Foundation Grant BK2007229.

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Authors and Affiliations

  1. Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 210029, Jiangsu, China

    Wencong Du, Ying Lu, Yuanyuan Cao, Juan Du, Hui Shi & Ling Zhou

  2. Department of Incretion, The Affiliated Nanjing First Hospital of NJMU, Nanjing, 210006, Jiangsu, China

    Qian Li & Jianhua Ma

  3. Department of Incretion, The Third Affiliated Hospital of NJMU, Yizheng, 211400, Jiangsu, China

    Xiaofang Yu & Yanqin Gao

  4. Department of Incretion, The Affiliated Changzhou Second Hospital of NJMU, Changzhou, 213003, Jiangsu, China

    Xinhua Ye & Jinluo Cheng

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  1. Wencong Du
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  2. Qian Li
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  3. Ying Lu
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  4. Xiaofang Yu
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  5. Xinhua Ye
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  6. Yanqin Gao
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  7. Jianhua Ma
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  8. Jinluo Cheng
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  9. Yuanyuan Cao
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  10. Juan Du
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  11. Hui Shi
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  12. Ling Zhou
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Corresponding author

Correspondence to Ling Zhou.

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Wencong Du and Qian Li equally contribute to this study.

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Du, W., Li, Q., Lu, Y. et al. Genetic variants in ADIPOQ gene and the risk of type 2 diabetes: a case–control study of Chinese Han population. Endocrine 40, 413–422 (2011). https://doi.org/10.1007/s12020-011-9488-8

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  • DOI: https://doi.org/10.1007/s12020-011-9488-8

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