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ADIPOR2 variant is associated with higher fasting glucose level in non-diabetic Chinese Han population

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Abstract

A high but normal fasting plasma glucose level in adults is a marker for insulin resistance and future development of type 2 diabetes mellitus. We aimed to investigate whether ADIPOR2 variants are associated with increased fasting plasma glucose (FPG) in non-diabetic Chinese Han subjects who had normal FPG levels. This study included 2038 subjects among the non-diabetic Chinese Han population. The ADIPOR2 polymorphisms were genotyped by the TaqMan method. For the analysis, participants were divided into low-normal FPG group (FPG < 4.88 mmol/L) and high-normal FPG group (6.1 mmol/L > FPG ≥ 4.88 mmol/L). We identified five single nucleotide polymorphisms (SNPs) of ADIPOR2 gene: rs10773989, rs2370055, rs9300298, rs10773983, and rs13611594. There was no significant difference in FPG levels between different genotypes of rs10773989, rs2370055, rs9300298, and rs13611594. Our data showed a significant association of rs10773983 with higher FPG levels, fasting insulin levels, and homeostatic model assessment of insulin resistance (HOMA-IR) in A-allele carriers (p = 0.006, p < 0.001, and p < 0.001, respectively). The subjects in high FPG group had higher median fasting insulin level (9.25 vs 8.16 μIU/mL, p = 0.003) and higher HOMA-IR (2.21 vs 1.58, p < 0.001) than those in normal FPG group. Subjects with the A-allele of rs10773983 compared to subjects with G-allele had 1.222-fold higher risk for high-normal FPG (OR = 1.222, 95%CI = 1.010–1.478, p = 0.039). Our findings suggest that ADIPOR2 rs10773983 polymorphism may be associated with an increased risk of high-normal FPG among non-diabetic Chinese Han subjects who have normal FPG levels.

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Funding

This study was funded by Beijing Municipal Administration of Hospitals’ Ascent Plan (grant number DFL20150701).

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Authors and Affiliations

  1. Clinical Laboratory Medicine, Beijing Shijitan Hospital, Capital Medical University, 10 Tieyi Road, Haidian District, Beijing, 100038, China

    Na Liu, Guihua Yang, Mei Hu, Jing Han, Yuyu Cai, Zhiying Hu, Chundi Jia & Man Zhang

  2. Peking University Ninth School of Clinical Medicine, 10 Tieyi Road, Haidian District, Beijing, 100038, China

    Na Liu, Guihua Yang, Mei Hu, Jing Han, Yuyu Cai, Zhiying Hu, Chundi Jia & Man Zhang

  3. Beijing Key Laboratory of Urinary Cellular Molecular Diagnostics, 10 Tieyi Road, Haidian District, Beijing, 100038, China

    Na Liu, Guihua Yang, Mei Hu, Jing Han, Yuyu Cai, Zhiying Hu, Chundi Jia & Man Zhang

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  1. Na Liu
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  2. Guihua Yang
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  3. Mei Hu
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  4. Jing Han
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  5. Yuyu Cai
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  7. Chundi Jia
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  8. Man Zhang
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Correspondence to Man Zhang.

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The study protocol was approved by the Beijing Shijitan Hospital Ethics Committee, Capital Medical University. Written informed consent was obtained from all the participants before their enrolment in the study.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Liu, N., Yang, G., Hu, M. et al. ADIPOR2 variant is associated with higher fasting glucose level in non-diabetic Chinese Han population. Int J Diabetes Dev Ctries 38, 403–408 (2018). https://doi.org/10.1007/s13410-018-0620-7

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  • DOI: https://doi.org/10.1007/s13410-018-0620-7

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