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Evaluation of the effect of l-thyroxin therapy on endothelial functions in patients with subclinical hypothyroidism

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Abstract

Subclinical hypothyroidism (SH) is characterized by normal serum free T4 (FT4), free T3 (FT3) levels and increased serum thyroid-stimulating hormone (TSH) levels. Endothelial dysfunction, which is an early step of atherosclerosis, has been reported in patients with subclinical hypothyroidism. The aim of this study is to evaluate endothelial functions and the effect of l-thyroxin (L-T4) therapy on endothelial functions in SH. Twenty-seven patients with SH and 22 healthy controls were evaluated in terms of endothelial functions, using brachial artery Doppler ultrasonography. After restorating euthyroidism, measurements were repeated. Baseline and nitroglycerin induced diameter (NID) of brachial artery were similar in patients with SH and the control group. Compared to the control group, the patients with SH showed significantly reduced flow-mediated diameter (FMD). Baseline and NID values were significantly higher after LT4 therapy in SH group. FMD also significantly increased after LT4 therapy. Hypothyroidism accelerates atherogenesis through modification of athero-sclerotic risk factors and direct effects on the blood vessels. In this study, we observed marked improvement in endothelial functions after L-T4 therapy in SH patients. We suggest that thyroid hormone replacement therapy may help to prevent atherosclerosis in this group of patients.

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Authors and Affiliations

  1. Internal Medicine Department, Istanbul Education and Research Hospital, Istanbul, Turkey

    Fatma Alibaz Oner & Mecdi Erguney

  2. Cardiology Division, Istanbul Florence Nightingale Hospital, Istanbul, Turkey

    Selen Yurdakul

  3. Coronary Intensive Care Unit, Istanbul Education and Research Hospital, Istanbul, Turkey

    Ender Oner

  4. Endocrinology and Metabolism Department, Istanbul Education and Research Hospital, Istanbul, Turkey

    Ayse Kubat Uzum

  5. Soğanlık yeni mahalle, Pamukkale sokak, Kentplus sitesi A3 blok, Daire:13, Kartal, Istanbul, Turkey

    Fatma Alibaz Oner

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  1. Fatma Alibaz Oner
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  2. Selen Yurdakul
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Correspondence to Fatma Alibaz Oner.

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Alibaz Oner, F., Yurdakul, S., Oner, E. et al. Evaluation of the effect of l-thyroxin therapy on endothelial functions in patients with subclinical hypothyroidism. Endocrine 40, 280–284 (2011). https://doi.org/10.1007/s12020-011-9465-2

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  • DOI: https://doi.org/10.1007/s12020-011-9465-2

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