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Cardiovascular disease risk characteristics of the main polycystic ovary syndrome phenotypes

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Abstract

The aim of this article was to evaluate the clinical, endocrine, and cardiovascular disease risk profile differences among main polycystic ovary syndrome (PCOS) phenotypes. One hundred and thirty-nine consecutive women were included in the study. Body mass index (BMI), serum follicle stimulating hormone (FSH), luteinizing hormone (LH), progesterone, estradiol, testosterone, dehydroepiandrosterone sulfate, fasting glucose, low density lipoprotein (LDL-C), total cholesterol, high density lipoprotein (HDL-C) high sensitive CRP, c-peptide, insulin, insulin sensitivity and carotid intima thickness were compared among different phenotype groups of PCOS: Group 1—PCO (polycystic ovaries)-anovulation (n = 34), Group 2—Hyperandrogenemia (HA)-anovulation (n = 30), Group 3—HA-PCO (n = 32), and Group 4—HA-PCO-anovulation (n = 43). Statistically significant differences among the different phenotype groups in terms of waist hip ratio, total cholesterol, LH, estradiol, fasting glucose, progesterone, free testosterone, and carotid intima media thickness were observed. The lowest mean CIMT was observed in Group 3, and the highest fasting glucose levels were in Group 4, while the lowest mean free testesterone was measured in Group 1. BMI, LDL-C, and total cholesterol showed significant positive correlations with CIMT (r = 0.411, P = 0.001; r = 0.258, P = 0.006; r = 0.199, P = 0.033). The lowest LDL-C, total cholesterol, and BMI were found in Group 3, but differences were not statistically significant. High-sensitive CRP levels were similar among the groups (P = 0.103). Group 3 PCOS with PCO and hyperandrogenemia phenotype has lower cardiovascular disease risk compared to other phenotypes.

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References

  1. L.J. Rajashekar, D. Krishna, M. Patil, Polycystic ovaries and infertility: our experience. Hum. Reprod. Sci. 1(2), 65–72 (2008)

    Article  Google Scholar 

  2. J.K. Zawdaki, A. Dunaif, Diagnostic criteria for polycystic ovary syndrome: toward a rationale approach, in Polycystic ovary syndrome, ed. by A. Dunaif, J.R. Givens, F. Haseltine, G.R. Merriam (Blackwell Scientific Publications, Boston, 1992), pp. 377–384

    Google Scholar 

  3. E. Carmina, R.A. Lobo, Do hyperandrogenic women with normal menses have polycystic ovary syndrome? Fertil. Steril. 71, 319–322 (1999)

    Article  PubMed  CAS  Google Scholar 

  4. E. Carmina, R.A. Lobo, Polycystic ovaries in women with normal menses. Am. J. Med. 111, 602–606 (2001)

    Article  PubMed  CAS  Google Scholar 

  5. J.R. Chang, Polycystic ovary syndrome: diagnostic criteria, in Polycystic ovary syndrome, ed. by R.J. Chang, J.J. Heindel, A. Dunaif (Marcel Dekker, New York, 2002), pp. 361–365

    Google Scholar 

  6. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group, Revised 2003 consensus on diagnostic criteria and long term health risks related to polycystic ovary syndrome. Fertil. Steril. 81, 19–25 (2004)

    Google Scholar 

  7. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group, Revised 2003 consensus on diagnostic criteria and long term health risks related to polycystic ovary syndrome. Hum. Reprod. 19, 41–47 (2004)

    Article  Google Scholar 

  8. A. Dokras, Cardiovascular disease risk factors in polycystic ovary syndrome. Semin. Reprod. Med. 26(1), 39–44 (2008)

    Article  PubMed  CAS  Google Scholar 

  9. E.O. Talbott, J.V. Zborowski, J.R. Rager, M.Y. Boudreaux, D.A. Edmundowicz, D.S. Guzick, Evidence for an association between metabolic cardiovascular syndrome and coronary and aortic calcification among women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 89, 5454–5461 (2004)

    Article  PubMed  CAS  Google Scholar 

  10. R.C. Christian, D.A. Dumesic, T. Behrenbeck, A.L. Oberg, P.F. Sheedy 2nd, L.A. Fitzpatrick, Prevalence and predictors of coronary artery calcification in women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 88, 2562–2568 (2003)

    Article  PubMed  CAS  Google Scholar 

  11. C.J.G. Kelly, A. Speirs, G.W. Gould, J.R. Petrie, H. Lyall, J.M.C. Connell, Altered vascular function in young women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 87, 742–746 (2002)

    Article  PubMed  CAS  Google Scholar 

  12. G. Paradisi, H.O. Steinberg, A. Hempfling, J. Cronin, G. Hook, M.K. Shepard, A.D. Baron, Polycystic ovary syndrome is associated with endothelial dysfunction. Circulation 103, 1410–1415 (2001)

    PubMed  CAS  Google Scholar 

  13. C.J. Alexander, E.P. Tangchitnob, N.E. Lepor, Polycystic ovary syndrome: a major unrecognized cardiovascular risk factor in women. Rev. Obstet. Gynecol. 2(4), 232–239 (2009)

    PubMed  Google Scholar 

  14. E. Guastella, R.A. Longo, E. Carmina, Clinical and endocrine characteristics of the main polycystic ovary syndrome phenotypes. Fertil. Steril. 94(6), 2197–2201 (2010)

    Article  PubMed  CAS  Google Scholar 

  15. D. Wiltgen, P.M. Spritzer, Variations in metabolic and cardiovascular risk in women with different polycystic ovary syndrome phenotypes. Fertil. Steril. 94(6), 2493–2496 (2010)

    Article  PubMed  Google Scholar 

  16. R.S. Legro, V.D. Castracane, R.P. Kauffman, Detecting insulin resistance in polycystic ovary syndrome: purposes and pitfalls. Obstet. Gynecol. Surv. 59(2), 141–154 (2004)

    Article  PubMed  Google Scholar 

  17. M. Luque-Ramírez, C. Mendieta-Azcona, F. Alvarez-Blasco, H.F. Escobar-Morreale, Androgen excess is associated with the increased carotid intima-media thickness observed in young women with polycystic ovary syndrome. Hum. Reprod. 22(12), 3197–3203 (2007)

    Article  PubMed  Google Scholar 

  18. M. Rizzo, K. Berneis, M. Hersberger, I. Pepe, G. Di Fede, G.B. Rini, G.A. Spinas, E. Carmina, Milder forms of atherogenic dyslipidemia in ovulatory versus anovulatory polycystic ovary syndrome phenotype. Hum. Reprod. 24(9), 2286–2292 (2009)

    Article  PubMed  CAS  Google Scholar 

  19. J.C. Lovejoy, G.A. Bray, M.O. Bourgeois, R. Macchiavelli, J.C. Rood, C. Greeson, C. Partington, Exogenous androgens influence body composition and regional body fat distribution in obese postmenopausal women—a clinical research center study. Clin. Endocrinol. Metab. 81(6), 2198–2203 (1996)

    Article  CAS  Google Scholar 

  20. C.D. Christakou, E. Diamanti-Kandarakis, Role of androgen excess on metabolic aberrations and cardiovascular risk in women with polycystic ovary syndrome. Womens Health 4(6), 583–594 (2008)

    CAS  Google Scholar 

  21. A.Y. Chang, C. Ayers, A. Minhajuddin, T. Jain, P. Nurenberg, J.A. De Lemos, R.A. Wild, R.J. Auchus, Polycystic ovarian syndrome and subclinical atherosclerosis among women of reproductive age in the Dallas heart study. Clin. Endocrinol. 74(1), 89–96 (2010)

    Article  Google Scholar 

  22. A. Karaer, S. Cavkaytar, I. Mert, U. Buyukkagnici, S. Batioglu, Cardiovascular risk factors in polycystic ovary syndrome. J. Obstet. Gynaecol. 30(4), 387–392 (2010)

    Article  PubMed  CAS  Google Scholar 

  23. R. Azziz, E. Carmina, D. Dewailly, E. Diamanti-Kandarakis, H.F. Escobar-Morreale, W. Futterweit, O.E. Janssen, R.S. Legro, R.J. Norman, A.E. Taylor, S.F. Witchel, Task Force on the Phenotype of the Polycystic Ovary Syndrome of The Androgen Excess and PCOS Society, The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report. Fertil. Steril. 91(2), 456–488 (2009)

    Article  PubMed  Google Scholar 

  24. I. Lambrinoudaki, Cardiovascular risk in postmenopausal women with the polycystic ovary syndrome. Maturitas 68(1), 13–16 (2010)

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Etlik Zübeyde Hanım Maternity & Women’s Health Teaching and Research Hospital, Ankara, Turkey

    Berna Dilbaz, Mehmet Cinar & Serdar Dilbaz

  2. Department of Obstetrics and Gynecology, Dr. Sami Ulus Women’s Health Teaching and Research Hospital, Demetevler 10. sok. 63/15, Yenimahalle, Ankara, Turkey

    Enis Özkaya

  3. Department of Endocrinology and Metabolism, Diskapı Yildirim Beyazit Teaching and Research Hospital, Ankara, Turkey

    Evrim Cakir

Authors
  1. Berna Dilbaz
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  2. Enis Özkaya
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  3. Mehmet Cinar
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  4. Evrim Cakir
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  5. Serdar Dilbaz
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Correspondence to Enis Özkaya.

Additional information

This study compared four different types of PCOS phenotypes in terms of metabolic, endocrine and cardiovascular risk factors. Ovulatory patients with hyperandrogenemia and polycystic ovaries have lower cardiovascular risk factors compared to others.

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Dilbaz, B., Özkaya, E., Cinar, M. et al. Cardiovascular disease risk characteristics of the main polycystic ovary syndrome phenotypes. Endocr 39, 272–277 (2011). https://doi.org/10.1007/s12020-011-9437-6

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  • DOI: https://doi.org/10.1007/s12020-011-9437-6

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