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Lack of association between interleukin-1a gene (IL-1a) C (-889) T variant and polycystic ovary syndrome in chinese women

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Abstract

Polycystic ovary syndrome (PCOS) is associated with the spontaneous development of an aberrant heterogeneous hormonal environment that thought to be related to multiple genetic or environmental factors remain undefined. Previous studies indicated that IL-1a gene C (-889) T, a polymorphism of the gene encoding a protein which involved in various immune responses, inflammatory processes and hematopoiesis, and is associated with PCOS. A total of 205 PCOS patients and 177 healthy controls were included in this study that used PCR-RFLP to detect C (-889) T variant of IL-1a gene. Clinical measures determined previously were included in the SPSS analysis. The results showed that the presence of IL-1a gene C (-889) T polymorphism in PCOS and healthy controls in Chinese women was not significantly different when studying genotype and allele frequencies. (Genotype: χ2 = 4.62, df = 2, P = 0.10; allele: χ2 = 1.35, df = 1, P = 0.25). Furthermore, no association was found between metabolic parameters observed and IL-1a genotypes in PCOS patients in this study. In conclusion, IL-1a gene C (-889) T polymorphism does not appear to be risk factor for PCOS in this population of Chinese women.

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References

  1. B.C.J.M. Fauser, Hum. Reprod 19(1), 41–47 (2008)

    Google Scholar 

  2. The Rotterdam ESHRE/ASRM-Sponsored PCOS Workshop Group, Fertil. Steril. 81, 19–25 (2003)

    Google Scholar 

  3. E.J. Lee, B. Oh, J.Y. Lee, K. Kimm, S.H. Lee, K.H. Baek, Fertil. Steril 89(5), 1213–1220 (2008)

    Article  CAS  PubMed  Google Scholar 

  4. A.K. Schreder, S. Tauchert, O. Ortmann, K. Diedrich, J.M. Weiss, Wien. Klin. Wochenschr 115(23), 812–821 (2003)

    Article  Google Scholar 

  5. E.O. Talbott, J.V. Zborowski, J.R. Rager, K.E. Kip, X. Xu, T.J. Orchard, J Womens Health 16(2), 191–197 (2007)

    Article  Google Scholar 

  6. I.J. Ketel, C.D. Stehouwer, E.H. Serné, T.J. Korsen, P.G. Hompes, Y.M. Smulders, R.T. de Jongh, R. Homburg, C.B. Lambalk, J. Clin. Endocrinol. Metab 93(9), 3365–3372 (2008)

    Article  CAS  PubMed  Google Scholar 

  7. Q. Liu, J. Hong, B. Cui, Y. Zhang, W. Gu, Z. Chi, Y. Su, G. Ning, Endocr 33(2), 165–170 (2008)

    Article  CAS  Google Scholar 

  8. I. Esinler, D. Aktas, U. Otegen, M. Alikasifoglu, H. Yarati, E. Tuncbilek, Reprod. BioMed. Online. 16(3), 356–360 (2008)

    Article  CAS  PubMed  Google Scholar 

  9. P. Valdés, A. Cerda, C. Barrenechea, M. Kehr, C. Soto, L.A. Salazar, Clin. Chim. Acta 390((1–2)), 63–66 (2008)

    Article  PubMed  Google Scholar 

  10. T. Baba, T. Endo, F. Sata, H. Honnma, Y. Kitajima, T. Hayashi, K. Manase, M. Kanaya, H. Yamada, H. Minakami, R. Kishi, T. Saito, Life Sci 81(10), 850–854 (2007)

    Article  CAS  PubMed  Google Scholar 

  11. G. Villuendas, J.I. Botella-Carretero, B. Roldán, J. Sancho, H.F. Escobar-Morreale, J.L. San Millán, Hum. Reprod 20(11), 184–191 (2005)

    Article  Google Scholar 

  12. E. Diamanti-Kandarakis, T. Paterakis, H.A. Kandarakis, Ann. N. Y. Acad. Sci 1092, 175–186 (2006)

    Article  CAS  PubMed  Google Scholar 

  13. J. Karasneh, A.H. Hajeer, J. Barrett, W.E. Ollier, M. Thornhill, A. Gul, Rheumatology 42, 860–864 (2003)

    Article  CAS  PubMed  Google Scholar 

  14. N. Gérard, M. Caillaud, A. Martoriati, G. Goudet, A.C. Lalmanach, J. Endocrinol 180, 203–212 (2004)

    Article  PubMed  Google Scholar 

  15. A. Kolbus, K. Walch, F. Nagele, R. Wenzl, G. Unfried, J.C. Huber, J. Reprod. Immunol 73(2), 188–193 (2007)

    Article  CAS  PubMed  Google Scholar 

  16. M.J. Nicklin, A. Weith, G.W. Duff, Genomics 19, 382–384 (1994)

    Article  CAS  PubMed  Google Scholar 

  17. H. Lee, B. Clark, H.C. Gooi, J. Stoves, C.G. Newstead, J. Clin. Pathol 57(1), 101–103 (2004)

    Article  CAS  Google Scholar 

  18. I. Matalliotakis, A. Kourtis, O. Koukoura, D. Panidis, Arch. Gynecol. Obstet 274(4), 187–197 (2006)

    Article  CAS  PubMed  Google Scholar 

  19. N.J. López, L. Jara, C.Y. Valenzuela, J. Periodontol 76(2), 234–243 (2005)

    Article  PubMed  Google Scholar 

  20. R.N. Apte, S. Dotan, M. Elkabets, M.R. White, E. Reich, Y. Carmi, X. Song, T. Dvozkin, Y. Krelin, E. Voronov, Cancer Metastasis Rev 25(3), 387–408 (2006)

    Article  CAS  PubMed  Google Scholar 

  21. A.W. Bushley, R. Ferrell, K. McDuffie, K.Y. Terada, M.E. Carney, P.J. Thompson, L.R. Wilkens, K.-H. Tung, R.B. Ness, M.T. Goodman, Gynecol. Oncol 95, 672–679 (2004)

    Article  CAS  PubMed  Google Scholar 

  22. M.O. Goodarzi, M.R. Jones, H.J. Antoine, M. Pall, Y.D. Chen, R. Azziz, J. Clin. Endocrinol. Metab 93(1), 300–303 (2008)

    Article  CAS  PubMed  Google Scholar 

  23. M.T. Rae, D. Niven, A. Ross, T. Forster, R. Lathe, H.O. Critchley, P. Ghazal, S.G. Hillier, J. Endocrinol 183(1), 19–28 (2004)

    Article  CAS  PubMed  Google Scholar 

  24. S. Kol, K.H. Wong, M. Ando, I. Ben-Shlomo, E.Y. Adashi, Endocr 11(3), 269–275 (1999)

    Article  CAS  Google Scholar 

  25. L.A. Hefler, E. Ludwig, A. Lebrecht, R. Zeillinger, D. Tong-Cacsire, H. Koelbl, S. Leodolter, C.B. Tempfer, J Soc Gynecol Investig 9(6), 386–390 (2002)

    Article  CAS  PubMed  Google Scholar 

  26. V. Pallottini, P. Bulzomi, P. Galluzzo, C. Martini, M. Marino, Infect Disord Drug Targets 8(1), 52–60 (2008)

    CAS  PubMed  Google Scholar 

  27. K. Wang, L. You, Y. Shi, L. Wang, M. Zhang, Z.J. Chen, Fertil. Steril 90(2), 378–384 (2008)

    Article  CAS  PubMed  Google Scholar 

  28. S. Hahn, U.H. Frey, W. Siffert, S. Tan, K. Mann, O.E. Janssen, Eur. J. Endocrinol 155, 763–770 (2006)

    Article  CAS  PubMed  Google Scholar 

  29. QIAamp® DNA Mini Kit and QIAamp DNA Blood Mini Kit Handbook

  30. J.Y. Um, K.S. Moon, K.M. Lee et al., Molecular Brain Res 115, 50–54 (2003)

    Article  CAS  Google Scholar 

Download references

Acknowledgments

This work was supported by the National Basic Research Program of China (2007CB511905), the National Natural Science Foundation of China (30571954) and the National Infrastructure Program of Chinese Genetic Resources (2006DKA21300).

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Authors and Affiliations

  1. Center for Genetics, National Research Institute for Family Planning, 12, Dahuisi Road, Haidian, Beijing, 100081, China

    Binbin Wang, Sirui Zhou, Jing Wang, Chunmei Liu, Jinting Yan, Yuan Mu & Xu Ma

  2. Reproductive Medicine Center, The First Affiliated Hospital, Anhui Medical University, Hefei, China

    Jingjing Liu, Feng Ni & Yunxia Cao

  3. Peking Union Medical College, Beijing, China

    Binbin Wang, Sirui Zhou, Jing Wang, Chunmei Liu, Jinting Yan, Yuan Mu & Xu Ma

  4. World Health Organization Collaborating Centre for Research in Human Reproduction, Beijing, China

    Xu Ma

Authors
  1. Binbin Wang
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  2. Sirui Zhou
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  3. Jing Wang
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  4. Jingjing Liu
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  5. Feng Ni
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  7. Jinting Yan
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  8. Yuan Mu
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  9. Yunxia Cao
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  10. Xu Ma
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Corresponding authors

Correspondence to Yunxia Cao or Xu Ma.

Additional information

B. Wang, S. Zhou authors contributed equally to the work.

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Wang, B., Zhou, S., Wang, J. et al. Lack of association between interleukin-1a gene (IL-1a) C (-889) T variant and polycystic ovary syndrome in chinese women. Endocr 35, 198–203 (2009). https://doi.org/10.1007/s12020-009-9152-8

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  • DOI: https://doi.org/10.1007/s12020-009-9152-8

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