Clinical Reviews in Bone and Mineral Metabolism

, Volume 8, Issue 4, pp 201–212 | Cite as

Primary Cilia-Mediated Mechanotransduction in Bone

  • Kristen L. Lee
  • David A. Hoey
  • Christopher R. Jacobs
Original Paper

Abstract

Mechanotransduction is a process in which cells sense applied mechanical stimulus and convert these forces into biochemical responses. This process regulates skeletal homeostasis, organization, and development, although the cellular mechanism that is responsible for mechanotransduction in bone is currently unknown. One candidate mechanosensor is the primary cilium, a single immotile organelle that extends from the surface of bone cells. The inhibition of primary cilia formation or associated components leads to reduced expression of mechanosensitive osteogenic genes, impaired osteoblastic differentiation, and skeletal phenotype irregularities. In this review, we discuss growing evidence supporting primary cilia as mediators of mechanically regulated skeletal homeostasis and development.

Keywords

Bone Primary cilia Mechanotransduction Mechanosensor 

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Kristen L. Lee
    • 1
  • David A. Hoey
    • 1
    • 2
  • Christopher R. Jacobs
    • 1
  1. 1.Department of Biomedical EngineeringColumbia UniversityNew YorkUSA
  2. 2.Department of AnatomyRoyal College of Surgeons in IrelandDublinIreland

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