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Primary Cilia-Mediated Mechanotransduction in Bone

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Abstract

Mechanotransduction is a process in which cells sense applied mechanical stimulus and convert these forces into biochemical responses. This process regulates skeletal homeostasis, organization, and development, although the cellular mechanism that is responsible for mechanotransduction in bone is currently unknown. One candidate mechanosensor is the primary cilium, a single immotile organelle that extends from the surface of bone cells. The inhibition of primary cilia formation or associated components leads to reduced expression of mechanosensitive osteogenic genes, impaired osteoblastic differentiation, and skeletal phenotype irregularities. In this review, we discuss growing evidence supporting primary cilia as mediators of mechanically regulated skeletal homeostasis and development.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, 1210 Amsterdam Avenue, Mail Code: 8904, New York, NY, 10027, USA

    Kristen L. Lee, David A. Hoey & Christopher R. Jacobs

  2. Department of Anatomy, Royal College of Surgeons in Ireland, Dublin, Ireland

    David A. Hoey

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  1. Kristen L. Lee
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  2. David A. Hoey
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Correspondence to Christopher R. Jacobs.

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Lee, K.L., Hoey, D.A. & Jacobs, C.R. Primary Cilia-Mediated Mechanotransduction in Bone. Clinic Rev Bone Miner Metab 8, 201–212 (2010). https://doi.org/10.1007/s12018-010-9078-y

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