Skip to main content

Advertisement

SpringerLink
Log in

Multicentric Reticulohistiocytosis: a Rare Yet Challenging Disease

  • Published:
Clinical Reviews in Allergy & Immunology Aims and scope Submit manuscript

Abstract

Multicentric reticulohistiocytosis (MRH) is a rare systemic inflammatory granulomatous disease that primarily manifests clinically with severe erosive arthritis and widespread papulonodular skin lesions but can involve multiple other organ systems. Despite the fact that this condition can become aggressive, debilitating as well as deforming with significant detrimental consequences, the etiology of this disease remains poorly understood. Moreover, the fact that MRH is such an uncommon disease has created an obstacle in the path of adequate clinical trials that are needed for better understanding of this phenomenon and for the development of treatment options for this patient population. In this review, we will attempt to discuss the epidemiology, pathophysiology, clinical features, associated conditions, differential diagnoses, diagnostic workup, and available treatments of MRH with the hope of creating a better understanding of this very challenging yet elusive disease process.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Barrow MV, Holubar K (1969) Multicentric reticulohistiocytosis. A review of 33 patients. Medicine 48(4):287–305

    Article  PubMed  CAS  Google Scholar 

  2. Tajirian AL, Malik MK, Robinson-Bostom L, Lally EV (2006) Multicentric reticulohistiocytosis. Clin Dermatol 24(6):486–92

    Article  PubMed  Google Scholar 

  3. Goltz RW, Laymon CW (1954) Multicentric reticulohistiocytosis of the skin and synovia; reticulohistiocytoma or ganglioneuroma. AMA Arch Dermatol Syphilol 69(6):717–31

    Article  CAS  Google Scholar 

  4. Lesher JL Jr, Allen BS (1984) Multicentric reticulohistiocytosis. J Am Acad Dermatol 11(4 Pt 2):713–23

    Article  PubMed  Google Scholar 

  5. Luz FB, Gaspar TAP, Kalil-Gaspar N, Ramos-e-Silva M (2001) Multicentric reticulohistiocytosis. J Eur Acad Dermatol Venereol: JEADV 15(6):524–31

    Article  PubMed  CAS  Google Scholar 

  6. Rapini RP (1993) Multicentric reticulohistiocytosis. Clin Dermatol 11(1):107–11

    Article  PubMed  CAS  Google Scholar 

  7. Yap FB (2009) Multicentric reticulohistiocytosis in a Malaysian Chinese lady: a case report and review of literature. Dermatol online J 15(1):2

    PubMed  Google Scholar 

  8. Matiz C, Ferguson PJ, Zaenglein A, Groh B, Bingham CA (2009) Papular xanthomas and erosive arthritis in a 3 year old girl, is this a new MRH variant? Pediatr Rheumatol Online J 7:15

    Article  PubMed  Google Scholar 

  9. Havill S, Duffill M, Rademaker M (1999) Multicentric reticulohistiocytosis in a child. Australas J Dermatol 40(1):44–6

    Article  PubMed  CAS  Google Scholar 

  10. Outland JD, Keiran SJ, Schikler KN, Callen JP (2002) Multicentric reticulohistiocytosis in a 14-year-old girl. Pediatr Dermatol 19(6):527–31

    Article  PubMed  Google Scholar 

  11. Candell Chalom E, Elenitsas R, Rosenstein ED, Kramer N (1998) A case of multicentric reticulohistiocytosis in a 6-year-old child. J Rheumatol 25(4):794–7

    PubMed  CAS  Google Scholar 

  12. Shiokawa S, Shingu M, Nishimura M, Yasuda M, Yamamoto M, Tawara T et al (1991) Multicentric reticulohistiocytosis associated with subclinical Sjogren’s syndrome. Clin Rheumatol 10(2):201–5

    Article  PubMed  CAS  Google Scholar 

  13. Ben Abdelghani K, Mahmoud I, Chatelus E, Sordet C, Gottenberg JE, Sibilia J (2010) Multicentric reticulohistiocytosis: an autoimmune systemic disease? Case report of an association with erosive rheumatoid arthritis and systemic Sjogren syndrome. Joint, bone, spine: revue du rhumatisme 77(3):274–6

    Article  Google Scholar 

  14. Trotta F, Castellino G, Lo MA (2004) Multicentric reticulohistiocytosis. Best Pract Res Clin Rheumatol 18(5):759–72

    Article  PubMed  Google Scholar 

  15. Malik MK, Regan L, Robinson-Bostom L, Pan TD, McDonald CJ (2005) Proliferating multicentric reticulohistiocytosis associated with papillary serous carcinoma of the endometrium. J Am Acad Dermatol 53(6):1075–9

    Article  PubMed  Google Scholar 

  16. Chen CH, Chen CH, Chen HA, Liao HT, Lin HY (2006) Multicentric reticulohistiocytosis presenting with destructive polyarthritis, laryngopharyngeal dysfunction, and a huge reticulohistiocytoma. J Clin Rheumatol: Pract Rep Rheum Musculoskelet Dis 12(5):252–4

    Google Scholar 

  17. Ho SG, Yu RC (2005) A case of multicentric reticulohistiocytosis with multiple lytic skull lesions. Clin Exp Dermatol 30(5):515–8

    Article  PubMed  CAS  Google Scholar 

  18. Baghestani S, Khosravi F, Dehghani Zahedani M, Mahboobi AA (2005) Multicentric reticulohistiocytosis presenting with papulonodular skin eruption and polyarthritis. Eur J Dermatol: EJD 15(3):196–200

    PubMed  Google Scholar 

  19. El-Haddad B, Hammoud D, Shaver T, Shahouri S (2011) Malignancy-associated multicentric reticulohistiocytosis. Rheumatol Int 31(9):1235–8

    Article  PubMed  Google Scholar 

  20. Hinchman KF, Wu JJ, Soden CE Jr, Waldman J, Dyson SW (2008) Multicentric reticulohistiocytosis associated with Burkitt lymphoma and adenocarcinoma. Cutis; Cutan Med Pract 82(2):113–4

    Google Scholar 

  21. de Zwart-Storm EA, van Marion AM, Gorter SL, Frank J, Kelleners-Smeets NW (2007) Multicentric reticulohistiocytosis: case report. Int J Dermatol 46(Suppl 3):39–41

    Article  PubMed  Google Scholar 

  22. Kishikawa T, Miyashita T, Fujiwara E, Shimomura O, Yasuhi I, Niino D et al (2007) Multicentric reticulohistiocytosis associated with ovarian cancer. Mod Rheumatol/Japan Rheum Assoc 17(5):422–5

    Article  Google Scholar 

  23. Tirumalae R, Rout P, Jayaseelan E, Shet A, Devi S, Kumar KR (2011) Paraneoplastic multicentric reticulohistiocytosis: a clinicopathologic challenge. Indian J Dermatol Venereol Leprology 77(3):318–20

    Article  Google Scholar 

  24. Tan BH, Barry CI, Wick MR, White KP, Brown JG, Lee A et al (2011) Multicentric reticulohistiocytosis and urologic carcinomas: a possible paraneoplastic association. J Cutan Pathol 38(1):43–8

    Article  PubMed  Google Scholar 

  25. Levine D, Miller S, Al-Dawsari N, Barak O, Gottlieb AB (2010) Paraneoplastic dermatoses associated with gynecologic and breast malignancies. Obstet Gynecol Surv 65(7):455–61

    Article  PubMed  Google Scholar 

  26. Rudd A, Dolianitis C, Varigos G, Howard A (2011) A case of multicentric reticulohistiocytosis responsive to azathioprine in a patient with no underlying malignancy. Australas J Dermatol 52(4):292–4

    Article  PubMed  Google Scholar 

  27. Han L, Huang Q, Liao KH, Chen LJ, Kong WY, Fu WW et al (2012) Multicentric reticulohistiocytosis associated with liver carcinoma: report of a case. Case Rep Dermatol 4(2):163–9

    Article  PubMed  Google Scholar 

  28. Bauer A, Garbe C, Detmar M, Kreuser ED, Gollnick H (1994) [Multicentric reticulohistiocytosis and myelodysplastic syndrome]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 45(2):91–96

    Article  PubMed  CAS  Google Scholar 

  29. Brackenridge A, Bashir T, Wheatley T (2005) Multicentric reticulohistiocytosis and pregnancy. BJOG: Int J Obstet Gynaecol 112(5):672–3

    Article  Google Scholar 

  30. Tsubamoto H, Horinosono H, Horie M (2000) Multicentric reticulohistiocytosis in a patient with severe preeclampsia. Arch Gynecol Obstet 264(1):35–6

    Article  PubMed  CAS  Google Scholar 

  31. Conaghan P, Miller M, Dowling JP, Cowen P, Littlejohn G (1993) A unique presentation of multicentric reticulohistiocytosis in pregnancy. Arthritis Rheum 36(2):269–72

    Article  PubMed  CAS  Google Scholar 

  32. Alexis AF, Strober BE (2005) Off-label dermatologic uses of anti-TNF-a therapies. J Cutan Med Surg 9(6):296–302

    Article  PubMed  Google Scholar 

  33. Benucci M, Sulla A, Manfredi M (2008) Cardiac engagement in multicentric reticulohistiocytosis: report of a case with fatal outcome and literature review. Intern Emerg Med 3(2):165–8

    Article  PubMed  Google Scholar 

  34. Adamopoulos IE, Wordsworth PB, Edwards JR, Ferguson DJ, Athanasou NA (2006) Osteoclast differentiation and bone resorption in multicentric reticulohistiocytosis. Hum Pathol 37(9):1176–85

    Article  PubMed  CAS  Google Scholar 

  35. Goto H, Inaba M, Kobayashi K, Imanishi Y, Kumeda Y, Inui K et al (2003) Successful treatment of multicentric reticulohistiocytosis with alendronate: evidence for a direct effect of bisphosphonate on histiocytes. Arthritis Rheum 48(12):3538–41

    Article  PubMed  Google Scholar 

  36. Taniguchi T, Asano Y, Okada A, Sugaya M, Sato S (2011) Ultraviolet light-induced Kobner phenomenon contributes to the development of skin eruptions in multicentric reticulohistiocytosis. Acta dermato-venereologica 91(2):160–3

    PubMed  Google Scholar 

  37. Aldridge RD, Main RA, Daly BM (1984) The Koebner’s response in multicentric reticulohistiocytosis. Cutis; Cutan Med Practit 34(1):78–80

    CAS  Google Scholar 

  38. Kocanaogullari H, Ozsan H, Oksel F, Ozturk G, Kandiloglu G, Ustun EE et al (1996) Multicentric reticulohistiocytosis. Clin Rheumatol 15(1):62–6

    Article  PubMed  CAS  Google Scholar 

  39. Jansen TL, Kruithof IG (2003) [Diagnostic image (141) Nodules in a patient with rheumatoid arthritis. Multicentric reticulohistiocytosis as a paraneoplastic manifestation]. Nederlands tijdschrift voor geneeskunde 147(22):1067

    PubMed  CAS  Google Scholar 

  40. Mukherjee S, Gangopadhyay DN (2012) Multicentric reticulohistiocytosis: a rare case report. Indian J Dermatol 57(4):302–3

    Article  PubMed  Google Scholar 

  41. Shah SP, Shah AM, Prajapati SM, Bilimoria FE (2011) Multicentric reticulohistiocytosis. Indian Dermatol Online J 2(2):85–7

    Article  PubMed  Google Scholar 

  42. Luz FB, Gaspar NK, Gaspar AP, Carneiro S, Ramos-e-Silva M (2007) Multicentric reticulohistiocytosis: a proliferation of macrophages with tropism for skin and joints, part I. Skinmed 6(4):172–8

    Article  PubMed  Google Scholar 

  43. Rao AG, Lakshmi TS, Vani V (2003) Multicentric reticulohistiocytosis. Indian J Dermatol Venereol Leprology 69(1):35–6

    CAS  Google Scholar 

  44. Sokolovic S, Kasumagic S (2009) [Multicentric reticulohistiocytosis]. Medicinski arhiv 63(2):108–109

    PubMed  Google Scholar 

  45. Nakajima Y, Sato K, Morita H, Watanabe T, Inoue K, Kashiwazaki S (1993) [Three cases of multicentric reticulohistiocytosis with arthritis]. Ryumachi [Rheumatism] 33(1):68–73

    CAS  Google Scholar 

  46. Bardin T (2004) Musculoskeletal features of disorders of lipid metabolism and multicentric reticulohistiocytosis. Curr Opin Rheumatol 16(1):76–9

    Article  PubMed  CAS  Google Scholar 

  47. Bogle MA, Tschen JA, Sairam S, McNearney T, Orsak G, Knox JM (2003) Multicentric reticulohistiocytosis with pulmonary involvement. J Am Acad Dermatol 49(6):1125–7

    Article  PubMed  Google Scholar 

  48. Anderson TE, Carr AJ, Chapman RS, Downie AW, Maclean GD (1968) Myositis and myotonia in a case of multicentric reticulohistiocytosis. British J Dermatol 80(1):39–45

    Article  CAS  Google Scholar 

  49. Arai S, Katsuoka K, Ishikawa A (2012) Multicentric reticulohistiocytosis presenting with the cutaneous features of photosensitivity dermatitis. J Dermatol 39(2):180–1

    Article  PubMed  Google Scholar 

  50. Allaire GS, Hidayat AA, Zimmerman LE, Minardi L (1990) Reticulohistiocytoma of the limbus and cornea. A clinicopathologic study of two cases. Ophthalmol 97(8):1018–22

    CAS  Google Scholar 

  51. Bakri SJ, Carlson JA, Meyer DR (2003) Recurrent solitary reticulohistiocytoma of the eyelid. Ophthal Plast Reconstr Surg 19(2):162–4

    Article  PubMed  Google Scholar 

  52. Eagle RC Jr, Penne RA, Hneleski IS Jr (1995) Eyelid involvement in multicentric reticulohistiocytosis. Ophthalmol 102(3):426–30

    Google Scholar 

  53. Webb-Detiege T, Sasken H, Kaur P (2009) Infiltration of histiocytes and multinucleated giant cells in the myocardium of a patient with multicentric reticulohistiocytosis. J Clin Rheumatol: Pract Rep Rheum Musculoskelet Dis 15(1):25–6

    Google Scholar 

  54. Yang HJ, Ding YQ, Deng YJ (2009) Multicentric reticulohistiocytosis with lungs and liver involved. Clin Exp Dermatol 34(2):183–5

    Article  PubMed  Google Scholar 

  55. Yee KC, Bowker CM, Tan CY, Palmer RG (1993) Cardiac and systemic complications in multicentric reticulohistiocytosis. Clin Exp Dermatol 18(6):555–8

    Article  PubMed  CAS  Google Scholar 

  56. West KL, Sporn T, Puri PK (2012) Multicentric reticulohistiocytosis: a unique case with pulmonary fibrosis. Arch Dermatol 148(2):228–32

    Article  PubMed  Google Scholar 

  57. Amor B, Kahan A, Laoussadi S, Mariette X (1987) Multicentric reticulohistiocytosis. A case with unusual clinical, radiologic and ultrastructural aspects. Revue du rhumatisme et des maladies osteo-articulaires 54(2):113–9

    PubMed  CAS  Google Scholar 

  58. Luz FB, Gaspar NK, Gaspar AP, Carneiro S, Ramos ESM (2007) Multicentric reticulohistiocytosis: a proliferation of macrophages with tropism for skin and joints, part II. Skinmed 6(5):227–33

    Article  PubMed  Google Scholar 

  59. Hoshina D, Shimizu T, Abe R, Murata J, Tanaka K, Shimizu H (2005) Multicentric reticulohistiocytosis associated with rheumatoid arthritis. Rheumatol Int 25(7):553–4

    Article  PubMed  Google Scholar 

  60. Vieira R, Cordeiro MR, Mariano A, Reis JP, Tellechea O, Figueiredo A (2004) Multiple cutaneous reticulohistiocytomas in a patient with rheumatoid arthritis. Dermatol online J 10(2):11

    PubMed  Google Scholar 

  61. Saito K, Fujii K, Awazu Y, Nakayamada S, Fujii Y, Ota T et al (2001) A case of systemic lupus erythematosus complicated with multicentric reticulohistiocytosis (MRH): successful treatment of MRH and lupus nephritis with cyclosporin A. Lupus 10(2):129–32

    Article  PubMed  CAS  Google Scholar 

  62. Takahashi M, Mizutani H, Nakamura Y, Shimizu M (1997) A case of multicentric reticulohistiocytosis, systemic sclerosis and Sjogren syndrome. J Dermatol 24(8):530–4

    PubMed  CAS  Google Scholar 

  63. Catterall MD, White JE (1978) Multicentric reticulohistiocytosis and malignant disease. British J Dermatol 98(2):221–4

    Article  CAS  Google Scholar 

  64. Aldridge RD, Main RA, Daly BM (1984) Multicentric reticulohistiocytosis and cancer. J Am Acad Dermatol 10(2 Pt 1):296–8

    Article  PubMed  CAS  Google Scholar 

  65. Kaul A, Tolat SN, Belgaumkar V, Mhaske CB (2010) Multicentric reticulohistiocytosis. Indian J Dermatol Venereol Leprology 76(4):404–7

    Article  Google Scholar 

  66. Nicol C, Quereux G, Renaut JJ, Renac F, Dreno B (2011) [Paraneoplastic multicentric reticulohistiocytosis]. Annales de dermatologie et de venereologie 138(5):405–408

    Article  PubMed  CAS  Google Scholar 

  67. Snow JL, Muller SA (1995) Malignancy-associated multicentric reticulohistiocytosis: a clinical, histological and immunophenotypic study. British J Dermatol 133(1):71–6

    Article  CAS  Google Scholar 

  68. Valencia IC, Colsky A, Berman B (1998) Multicentric reticulohistiocytosis associated with recurrent breast carcinoma. J Am Acad Dermatol 39(5 Pt 2):864–6

    Article  PubMed  CAS  Google Scholar 

  69. Santilli D, Lo Monaco A, Cavazzini PL, Trotta F (2002) Multicentric reticulohistiocytosis: a rare cause of erosive arthropathy of the distal interphalangeal finger joints. Annals Rheum Dis 61(6):485–7

    Article  CAS  Google Scholar 

  70. Horvath JR, Hoffman GS (1999) Multicentric reticulohistiocytosis: a mimic of gout and rheumatoid arthritis. Cleveland Clinic J Med 66(3):166–72

    Article  CAS  Google Scholar 

  71. Munoz-Santos C, Sabat M, Saez A, Gratacos J, Luelmo J (2007) Multicentric reticulohistiocytosis-mimicking dermatomyositis. Case report and review of the literature. Dermatol (Basel, Switzerland) 214(3):268–271

    Article  Google Scholar 

  72. Levin J, Werth VP (2006) Skin disorders with arthritis. Best Pract Res Clin Rheumatol 20(4):809–26

    Article  PubMed  Google Scholar 

  73. Bennassar A, Mas A, Guilabert A, Julia M, Mascaro-Galy JM, Herrero C (2011) Multicentric reticulohistiocytosis with elevated cytokine serum levels. J Dermatol 38(9):905–10

    PubMed  CAS  Google Scholar 

  74. Badlissi F, Setty Y, Folzenlogen D (2002) A case of multicentric reticulohistiocytosis initially misdiagnosed as lupus. J Clin Rheumatol: Pract Rep Rheum Musculoskeletal Dis 8(4):232–3

    Google Scholar 

  75. Hsiung SH, Chan EF, Elenitsas R, Kolasinski SL, Schumacher HR, Werth VP (2003) Multicentric reticulohistiocytosis presenting with clinical features of dermatomyositis. J Am Acad Dermatol 48(2 Suppl):S11–4

    Article  PubMed  Google Scholar 

  76. Trotta F, Colina M (2012) Multicentric reticulohistiocytosis and fibroblastic rheumatism. Best Pract Res Clin Rheumatol 26(4):543–57

    Article  PubMed  CAS  Google Scholar 

  77. Abdul Razack EM, Dharmaraj S, Krishnaram AS, Selvaraj AM (1988) Multicentric reticulohistiocytosis masquerading as lepromatous leprosy. Indian J Lepr 60(4):604–8

    PubMed  CAS  Google Scholar 

  78. Chauhan A, Mikulik Z, Hackshaw KV (2007) Multicentric reticulohistiocytosis with positive anticyclic citrullinated antibodies. J Natl Med Assoc 99(6):678–80

    PubMed  Google Scholar 

  79. Luz FB, Gaspar AP, Ramos-e-Silva M, Carvalho da Fonseca E, Villar EG, Cordovil Pires AR (2005) Immunohistochemical profile of multicentric reticulohistiocytosis. Skinmed 4(2):71–7

    Article  PubMed  Google Scholar 

  80. De Knop KJ, Aerts NE, Ebo DG, Van Offel JF, Stevens WJ, De Clerck LS (2011) Multicentric reticulohistiocytosis associated arthritis responding to anti-TNF and methotrexate. Acta clinica Belgica 66(1):66–9

    PubMed  Google Scholar 

  81. Stock N, Saikali S, Chevrant-Breton J, Leroy JP, Le Gall F (2005) [Multicentric reticulohistiocytosis: report of a case with systemic disease]. Annales de pathologie 25(1):50–53

    Article  PubMed  Google Scholar 

  82. Nakajima Y, Sato K, Morita H, Torikai S, Hidano A, Nishioka K et al (1992) Severe progressive erosive arthritis in multicentric reticulohistiocytosis: possible involvement of cytokines in synovial proliferation. J Rheumatol 19(10):1643–6

    PubMed  CAS  Google Scholar 

  83. Qureshi F, Leong P, Quinlan CD, Cunnane K (1993) Multicentric reticulohistiocytosis—a case report. Irish J Med Sci 162(8):313–4

    Article  PubMed  CAS  Google Scholar 

  84. Spadaro A, Riccieri V, Sili-Scavalli A, Innocenzi D, Pranteda G, Taccari E (1994) [Value of cytological analysis of the synovial fluid in multicentric reticulohistiocytosis. A case]. Revue du rhumatisme (Ed francaise: 1993) 61(7–8):554–557

    CAS  Google Scholar 

  85. Uhl M, Gutfleisch J, Rother E, Langer M (1996) Multicentric reticulohistiocytosis. A report of 3 cases and review of literature. Bildgebung = Imaging 63(2):126–9

    PubMed  CAS  Google Scholar 

  86. Pandhi RK, Vaswani N, Ramam M, Singh MK, Bhutani LK (1990) Multicentric reticulohistiocytosis: response to dexamethasone pulse therapy. Arch Dermatol 126(2):251–2

    Article  PubMed  CAS  Google Scholar 

  87. Shannon SE, Schumacher HR, Self S, Brown AN (2005) Multicentric reticulohistiocytosis responding to tumor necrosis factor-alpha inhibition in a renal transplant patient. J Rheumatol 32(3):565–7

    PubMed  Google Scholar 

  88. Fedler R, Frantzmann Y, Schwarze EW, Frosch PJ (1995) [Multicenter reticulohistiocytosis. Therapy with azathioprine and prednisolone]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 46(2):118–120

    Article  PubMed  CAS  Google Scholar 

  89. Gourmelen O, Le Loet X, Fortier-Beaulieu M, Thomine E, Ledan G, Lauret P et al (1991) Methotrexate treatment of multicentric reticulohistiocytosis. J Rheumatol 18(4):627–8

    PubMed  CAS  Google Scholar 

  90. Hiramanek N, Kossard S, Barnetson RS (2002) Multicentric reticulohistiocytosis presenting with a rash and arthralgia. Australasian J Dermatol 43(2):136–9

    Article  Google Scholar 

  91. Rentsch JL, Martin EM, Harrison LC, Wicks IP (1998) Prolonged response of multicentric reticulohistiocytosis to low dose methotrexate. J Rheumatol 25(5):1012–5

    PubMed  CAS  Google Scholar 

  92. Cash JM, Tyree J, Recht M (1997) Severe multicentric reticulohistiocytosis: disease stabilization achieved with methotrexate and hydroxychloroquine. J Rheumatol 24(11):2250–3

    PubMed  CAS  Google Scholar 

  93. Blanco JJ, Hernandez FJ, Cerezo JG, Garcia IS, Rubio FC, Rodriguez JJ (2002) Multicentric reticulohistiocytosis. The long course of a rare disease. Scandinavian J Rheumatol 31(2):107–9

    Article  Google Scholar 

  94. Sellam J, Deslandre CJ, Dubreuil F, Arfi S, Kahan A (2005) Refractory multicentric reticulohistiocytosis treated by infliximab: two cases. Clin Exp Rheumatol 23(1):97–9

    PubMed  CAS  Google Scholar 

  95. Traczewski P, Rudnicka L (2008) Adalimumab in dermatology. British J Clin Pharmacol 66(5):618–25

    CAS  Google Scholar 

  96. Kalajian AH, Callen JP (2008) Multicentric reticulohistiocytosis successfully treated with infliximab: an illustrative case and evaluation of cytokine expression supporting anti-tumor necrosis factor therapy. Arch Dermatol 144(10):1360–6

    Article  PubMed  CAS  Google Scholar 

  97. Liang GC, Granston AS (1996) Complete remission of multicentric reticulohistiocytosis with combination therapy of steroid, cyclophosphamide, and low-dose pulse methotrexate. Case report, review of the literature, and proposal for treatment. Arthritis Rheum 39(1):171–174

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, 451 Health Sciences Drive, Suite 6510, Davis, CA, 95616, USA

    Arshia D. Islam, Stanley M. Naguwa, Gurtej S. Cheema & M. Eric Gershwin

  2. Department of Radiology, University of California at Davis, Sacramento Medical Center, Sacramento, CA, 95817, USA

    John C. Hunter

Authors
  1. Arshia D. Islam
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stanley M. Naguwa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Gurtej S. Cheema
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. John C. Hunter
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Eric Gershwin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. Eric Gershwin.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Islam, A.D., Naguwa, S.M., Cheema, G.S. et al. Multicentric Reticulohistiocytosis: a Rare Yet Challenging Disease. Clinic Rev Allerg Immunol 45, 281–289 (2013). https://doi.org/10.1007/s12016-013-8362-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12016-013-8362-2

Keywords

Search

Navigation