Skip to main content

Advertisement

SpringerLink
Log in

Multicentric reticulohistiocytosis associated with ovarian cancer

  • CASE REPORT
  • Published:
Modern Rheumatology

Abstract

Multicentric reticulohistiocytosis (MR) is an uncommon disease characterized by joint and cutaneous manifestations. The diagnosis must be confirmed by histological evidence of typical histiocytes and multinucleated giant cells. Many conditions, including malignancy, have been described in association with MR. We herein report a female case of MR in whom partial improvement was obtained by steroid and low-dose methotrexate treatments. However, ovarian cancer was found and therefore a surgical resection and chemotherapy were performed. These treatments resulted in the complete resolution of the skin and joint symptoms. These findings support the close linkage between MR and malignancy and the efficacy of cytotoxic drugs for the treatment of MR.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. F Trotta G Castellino A Lo Monaco (2004) ArticleTitleMulticentric reticulohistiocytosis Best Pract Res Clin Rheumatol 18 759–72 Occurrence Handle15454131 Occurrence Handle10.1016/j.berh.2004.06.002

    Article  PubMed  Google Scholar 

  2. JD Gorman C Danning HR Schumacher JH Klippel JC Davis SuffixJr (2000) ArticleTitleMulticentric reticulohistiocytosis: case report with immunohistochemical analysis and literature review Arthritis Rheum 43 930–8 Occurrence Handle10765941 Occurrence Handle10.1002/1529-0131(200004)43:4<930::AID-ANR27>3.0.CO;2-A Occurrence Handle1:STN:280:DC%2BD3c3islSjug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  3. DA Campbell NL Edwards (1991) ArticleTitleMulticentric reticulohistiocytosis: systemic macrophage disorder Baillieres Clin Rheumatol 5 301–19 Occurrence Handle1756586 Occurrence Handle10.1016/S0950-3579(05)80285-7 Occurrence Handle1:STN:280:DyaK38%2Fpslaiug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  4. MV Barrow K Holubar (1969) ArticleTitleMulticentric reticulohistiocytosis. A review of 33 patients Medicine 48 287–305 Occurrence Handle4895722 Occurrence Handle1:STN:280:DyaF1M3mtFOrsw%3D%3D Occurrence Handle10.1097/00005792-196907000-00002

    Article  PubMed  CAS  Google Scholar 

  5. JG Kenik F Fok CJ Huerter JA Hurley JF Stanosheck (1990) ArticleTitleMulticentric reticulohistiocytosis in a patient with malignant melanoma: a response to cyclophosphamide and a unique cutaneous feature Arthritis Rheum 33 1047–51 Occurrence Handle2369421 Occurrence Handle10.1002/art.1780330720 Occurrence Handle1:STN:280:DyaK3czhsV2rtw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  6. G Gibson M Cassidy P O'Connell GM Murphy (1995) ArticleTitleMulticentric reticulohistiocytosis associated with recurrence of malignant melanoma J Am Acad Dermatol 32 134–6 Occurrence Handle7822508 Occurrence Handle10.1016/0190-9622(95)90215-5 Occurrence Handle1:STN:280:DyaK2M7it1Olsg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  7. BA Janssen J Kencian PM Brooks (1992) ArticleTitleClose temporal and anatomic relationship between multicentric reticulohistiocytosis and carcinoma of the breast J Rheumatol 19 322–4 Occurrence Handle1629839 Occurrence Handle1:STN:280:DyaK38zjtlCrsQ%3D%3D

    PubMed  CAS  Google Scholar 

  8. WW Ginsburg JD O'Duffy JL Morris KA Huston (1989) ArticleTitleMulticentric reticulohistiocytosis: response to alkylating agents in six patients Ann Intern Med 111 384–8 Occurrence Handle2764405 Occurrence Handle1:STN:280:DyaL1MzkvF2jtQ%3D%3D

    PubMed  CAS  Google Scholar 

  9. GC Liang AS Granston (1996) ArticleTitleComplete remission of multicentric reticulohistiocytosis with combination therapy of steroid, cyclophosphamide, and low-dose pulse methotrexate. Case report, review of the literature, and proposal for treatment Arthritis Rheum 39 171–4 Occurrence Handle8546728 Occurrence Handle10.1002/art.1780390125 Occurrence Handle1:STN:280:DyaK287jtlakug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  10. IC Valencia A Colsky B Berman (1998) ArticleTitleMulticentric reticulohistiocytosis associated with recurrent breast carcinoma J Am Acad Dermatol 39 IssueID5 Pt 2 864–6 Occurrence Handle9810917 Occurrence Handle10.1016/S0190-9622(98)70367-6 Occurrence Handle1:STN:280:DyaK1M%2FislSnsA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  11. JC Nunnink PA Krusinski JW Yates (1985) ArticleTitleMulticentric reticulohistiocytosis and cancer: a case report and review of the literature Med Pediatr Oncol 13 273–9 Occurrence Handle2412096 Occurrence Handle10.1002/mpo.2950130506 Occurrence Handle1:STN:280:DyaL2M3psFOjtg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  12. K Kishimoto (2005) ArticleTitleA case of multicentric reticulohistiocytosis whose cutaneous lesions rapidly improved after treatment of pharyngeal carcinoma (in Japanese) Rinsho Hifuka 59 986–9

    Google Scholar 

  13. C Ohda (2004) ArticleTitleA case of multicentric reticulohistiocytosis preceding the aggravation of breast cancer (in Japanese) Rinsho Hifuka 58 732–4

    Google Scholar 

  14. MK Malik L Regan L Robinson-Bostom TD Pan CJ McDonald (2005) ArticleTitleProliferating multicentric reticulohistiocytosis associated with papillary serous carcinoma of the endometrium J Am Acad Dermatol 53 1075–9 Occurrence Handle16310073 Occurrence Handle10.1016/j.jaad.2005.08.019

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of General Internal Medicine, NHO National Nagasaki Medical Center, Nagasaki, Japan

    Takayuki Kishikawa, Taichiro Miyashita, Misato Amenomori, Hideaki Osumimoto & Mitsuhiko Osumi

  2. Department of Obstetrics and Gynecology, NHO National Nagasaki Medical Center, Nagasaki, Japan

    Emiko Fujiwara, Osamu Shimomura & Ichiro Yasuhi

  3. Department of Pathology, NHO National Nagasaki Medical Center, Nagasaki, Japan

    Daisuke Niino & Masahiro Ito

  4. Clinical Research Center, NHO National Nagasaki Medical Center, 2-1001-1 Kubara, Omura, Nagasaki, 856-8562, Japan

    Kiyoshi Migita

  5. First Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan

    Katsumi Eguchi

Authors
  1. Takayuki Kishikawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Taichiro Miyashita
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Emiko Fujiwara
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Osamu Shimomura
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ichiro Yasuhi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Daisuke Niino
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Masahiro Ito
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Misato Amenomori
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Hideaki Osumimoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Mitsuhiko Osumi
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Katsumi Eguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Kiyoshi Migita
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kiyoshi Migita.

About this article

Cite this article

Kishikawa, T., Miyashita, T., Fujiwara, E. et al. Multicentric reticulohistiocytosis associated with ovarian cancer. Mod Rheumatol 17, 422–425 (2007). https://doi.org/10.1007/s10165-007-0600-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10165-007-0600-0

Key words

Search

Navigation