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Atherosclerosis in Autoimmune Rheumatic Diseases—Mechanisms and Clinical Findings

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Abstract

Atherosclerosis is one of the major entities leading to morbidity and mortality in the western world. It is known now that atherosclerosis cannot be explained merely by the presence of the Framingham traditional risk factors and that autoimmunity takes a significant role in its pathogenesis. It is also known that individuals with autoimmune diseases demonstrate increased incidence of cardiovascular manifestations and subclinical atherosclerotic disease. The mechanisms for the assumed accelerated atherosclerosis in diseases such as systemic lupus erythematosus, rheumatoid arthritis, antiphospholipid syndrome, and systemic sclerosis include the classical risk factors, but may also be due to chronic inflammatory processes and immune dysregulation. Autoantibodies, autoantigens, pro-inflammatory cytokines, and infectious agents play a role in that process. Involvement of autoimmunity in the pathogenesis of accelerated atherosclerosis in rheumatic diseases and the common pathway that leads to this condition may lead to significant change in prevention of treatment.

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Acknowledgments

This study was supported in part by the Federico Foundation (to Y Sherer and Y Shoenfeld).

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Authors and Affiliations

  1. Department of Medicine B and Center of Autoimmune diseases, Sheba Medical Center, Tel-Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Hasya Zinger, Yaniv Sherer & Yehuda Shoenfeld

  2. Hospital Management, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel

    Yaniv Sherer

  3. Laura Schwarz-Kipp Research of Autoimmune Diseases, Tel Aviv, Israel

    Yehuda Shoenfeld

  4. Department of Medicine B, Sheba Medical Center, Tel-Hashomer, 52621, Israel

    Yehuda Shoenfeld

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  1. Hasya Zinger
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  2. Yaniv Sherer
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  3. Yehuda Shoenfeld
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Correspondence to Yehuda Shoenfeld.

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Zinger, H., Sherer, Y. & Shoenfeld, Y. Atherosclerosis in Autoimmune Rheumatic Diseases—Mechanisms and Clinical Findings. Clinic Rev Allerg Immunol 37, 20–28 (2009). https://doi.org/10.1007/s12016-008-8094-x

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