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The Role of CD4+CD25+ T Regulatory Cells in Autoimmune Diseases

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Abstract

Among the several mechanisms that play role in maintaining peripheral self-tolerance is the existence of a unique CD4+CD25+ population of naturally occurring regulatory T (Treg) cells that actively prevent both the activation and the effector function of autoreactive T cells that have escaped different mechanisms of tolerance. Many studies have shown the benefit of targeting this cell population by restoring self-tolerance. Therapies that could possibly increase the suppressive ability of T regulatory cells were proven to improve that course of autoimmune diseases.

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Authors and Affiliations

  1. Division of Allergy and Clinical Immunology, Bnai-Zion Medical Center, Technion, Rapaport, Faculty of Medicine, Haifa, Israel

    E. Toubi

  2. Division of Allergy and Clinical Immunology, Bnai-Zion Medical Center, Golomb Str. 47, P.O.B. 4, Haifa, Israel

    E. Toubi

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Correspondence to E. Toubi.

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Toubi, E. The Role of CD4+CD25+ T Regulatory Cells in Autoimmune Diseases. Clinic Rev Allerg Immunol 34, 338–344 (2008). https://doi.org/10.1007/s12016-007-8043-0

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  • DOI: https://doi.org/10.1007/s12016-007-8043-0

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