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A Mesenchymal stem cell Aging Framework, from Mechanisms to Strategies

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Abstract

Mesenchymal stem cells (MSCs) are extensively researched for therapeutic applications in tissue engineering and show significant potential for clinical use. Intrinsic or extrinsic factors causing senescence may lead to reduced proliferation, aberrant differentiation, weakened immunoregulation, and increased inflammation, ultimately limiting the potential of MSCs. It is crucial to comprehend the molecular pathways and internal processes responsible for the decline in MSC function due to senescence in order to devise innovative approaches for rejuvenating senescent MSCs and enhancing MSC treatment. We investigate the main molecular processes involved in senescence, aiming to provide a thorough understanding of senescence-related issues in MSCs. Additionally, we analyze the most recent advancements in cutting-edge approaches to combat MSC senescence based on current research. We are curious whether the aging process of stem cells results in a permanent “memory” and if cellular reprogramming may potentially revert the aging epigenome to a more youthful state.

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Data sharing is not applicable to this article as no datasets were generated or analysed during the current study.

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  1. Nanbu County People’s Hospital, Nanchong City, 637300, Sichuan Province, China

    Hongqing Zhao

  2. Graduate School of PLA Medical College, Chinese PLA General Hospital, Beijing, 100083, China

    Houming Zhao & Shuaifei Ji

  3. Jinzhou Medical University, No.82 Songpo Road, Guta District, Jinzhou, 121001, Liaoning Province, China

    Hongqing Zhao

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Hongqing Zhao: Conceptualization, Investigation, Writing - original draft. Houming Zhao: Methodology, Draw. Shuaifei Ji: Supervision, Writing - original draft and revision. All of the authors have read and approved the final manuscript. Hongqing Zhao and Houming Zhao contributed to this work equally.

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Zhao, H., Zhao, H. & Ji, S. A Mesenchymal stem cell Aging Framework, from Mechanisms to Strategies. Stem Cell Rev and Rep (2024). https://doi.org/10.1007/s12015-024-10732-4

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