Abstract
Epigenetic regulation, mainly involving DNA methylation, histone modification, and noncoding RNAs (ncRNAs), is essential for the regulation of multiple cellular processes. Dental-derived mesenchymal stem cells (DMSCs), a kind of multipotent cells derived from dental tissues, are impactful in regenerative medicine. Recent studies have shown that epigenetic regulation plays a major role in DMSCs. Therefore, exploring how epigenetic regulation is involved in DMSCs may be of guiding significance for tissue repair and regeneration or for exploring more effective treatments. A number of research of ncRNAs in DMSCs have been reported. However, little is known about the roles of DNA methylation and histone modifications in DMSCs. In this review, we summarize the important roles of DNA methylation and histone modifications of the fate of DMSCs.
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The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.
References
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This work was supported by Clinical Medical Technology Innovation Guidance Project of Hunan Province in China, 2020SK53501.
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BYZ: conceptualization, writing—original draft, visualization, writing—review and editing. GL: funding acquisition, and supervision. JHH: funding acquisition, and supervision. All authors have read and agreed to the published version of the manuscript.
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Zeng, B., Liu, G. & Huang, J. DNA Methylation and Histone Modification in Dental-derived Mesenchymal Stem Cells. Stem Cell Rev and Rep 18, 2797–2816 (2022). https://doi.org/10.1007/s12015-022-10413-0
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DOI: https://doi.org/10.1007/s12015-022-10413-0