Abstract
Dental mesenchymal stem cells (MSCs) are characterized by unlimited self-renewal ability and high multidirectional differentiation potential. Since dental MSCs can be easily isolated and exhibit a high capability to differentiate into odontogenic cells, they are considered as attractive therapeutic agents in regenerative dentistry. Recently, MSC-derived extracellular vesicles (MSC-EVs) have attracted widespread attention as carriers for cell-free therapy due to their potential functions. Many studies have shown that MSC-EVs can mediate microenvironment at tissue damage site, and coordinate the regeneration process. Additionally, MSC-EVs can mediate intercellular communication, thus affecting the phenotypes and functions of recipient cells. In this review, we mainly summarized the types of MSCs that could be potentially applied in regenerative dentistry, the possible molecular cargos of MSC-EVs, and the major effects of MSC-EVs on the therapeutic induction of osteogenic differentiation.
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References
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Funding
This work was supported by Guangdong Basic and Applied Basic Research Foundation (General Program: 2020A1515010237); Shenzhen Key Medical Discipline Construction Fund (No.SZXK039); and Special Fund for Science and Technology Development of Longgang District, Shenzhen (LGKCYLWS2021000031).
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Haiying Kong and Peiqi Liu finished the writing-original draft; Hongwen Li, Xiantao Zeng, Peiwu Xu, Xinhui Yao and Senqing Liu were involved in investigation and validation; Chak Kwong Cheng did conceptualization and editing; Jian Xu performed supervision and funding acquisition.
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Kong, H., Liu, P., Li, H. et al. Mesenchymal Stem Cell-Derived Extracellular Vesicles: The Novel Therapeutic Option for Regenerative Dentistry. Stem Cell Rev and Rep 19, 46–58 (2023). https://doi.org/10.1007/s12015-022-10342-y
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DOI: https://doi.org/10.1007/s12015-022-10342-y