Skip to main content

Advertisement

Log in

Recent Advances in the Diagnosis and Management of Bladder Cancer

  • Review Paper
  • Published:
Cell Biochemistry and Biophysics Aims and scope Submit manuscript

Abstract

The most common malignancy of urinary tract is bladder cancer. It is one of the most widespread cancers of the world and ranks nine among frequent malignancies existing in world. The only solution to above burning problem is timely diagnosis at earlier stage, and the cancer research is being forwarded in this direction. There are various prominent gene modifications responsible for growth of bladder cancer. The present review is focused on recent advances in the field of cancer makers involving, genetic, urinary, pathological, etc., approaches to contain the deadly process of carcinogenesis. The present review provides an insight on the emerging biomarkers that could be developed to boost current bladder cancer detection strategies. This shall help timely diagnosis of this deadly disease at early stage, thereby, helping bladder cancer patients to fight against this iniquity of life.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Jemal, A., Bray, F., Center, M. M., Ferlay, J., Ward, E., & Forman, D. (2011). Global cancer statistics. CA: A Cancer Journal for Clinicians, 61, 69–902.

    Google Scholar 

  2. Kaufman, D. S., Shipley, W. U., & Feldman, A. S. (2009). Bladder cancer. Lancet, 374(9685), 239–249.

    Article  CAS  PubMed  Google Scholar 

  3. Lagwinski, N., Thomas, A., Stephenson, A. J., Campbell, S., Hoschar, A. P., El-Gabry, E., et al. (2007). Squamous cell carcinoma of the bladder, a clinicopathologic analysis of 45 cases. American Journal of Surgery Pathology, 31, 1777–1787.

    Article  Google Scholar 

  4. Vishnu, P., Mathew, J., & Tan, W. W. (2011). Current therapeutic strategies for invasive and metastatic bladder cancer. Oncology Targets Therapy, 4, 97–113.

    CAS  Google Scholar 

  5. Vineis, P., Esteve, J., Hartge, P., et al. (1998). Effects of timing and type of tobacco in cigarette induced bladder cancer. Cancer Research, 48, 3849–3852.

    Google Scholar 

  6. Lamm, D., & Torti, F. (1996). Bladder cancer 1996. CA: A Cancer Journal for Clinicians, 49, 93–112.

    Google Scholar 

  7. Botteman, M. F., Pashos, C. L., Redaelli, A., Laskin, B., & Hauser, R. (2003). The health economics of bladder cancer, a comprehensive review of the published literature. Pharmacoeconomics, 21, 1315–1330.

    Article  PubMed  Google Scholar 

  8. Botteman, M. F., Pashos, C. L., Hauser, R. S., Laskin, B. L., & Redaelli, A. (2003). Quality of life aspects of bladder cancer, a review of the literature. Quality Life Research, 12, 675–688.

    Article  CAS  Google Scholar 

  9. Herr, H. W., & Schneider, M. (2001). Outpatient flexible cystoscopy in men, a randomized study of patient tolerance. Journal of Urology, 165, 1971–1972.

    Article  CAS  PubMed  Google Scholar 

  10. van der Poel, H. G., & Debruyne, F. M. (2001). Can biological markers replace cystoscopy? An update. Current Opinions Urology, 11, 503–509.

    Article  Google Scholar 

  11. Herr, H. W. (1999). The natural history of a T1 bladder cancer, life-long tumour diathesis. British Journal of Urology International, 84, 1102–1103.

    Article  CAS  Google Scholar 

  12. Babjuk, M., Soukup, V., Pesl, M., Kostírová, M., Drncová, E., Smolová, H., et al. (2008). Urinary cytology and quantitative BTA and UBC tests in surveillance of patients with pTapT1 bladder urothelial carcinoma. Urology, 71, 718–722.

    Article  CAS  PubMed  Google Scholar 

  13. Lotan, Y., & Roehrborn, C. G. (2003). Sensitivity and specificity of commonly available bladder tumor markers versus cytology, results of a comprehensive literature review and meta-analyses. Urology, 61, 109–118.

    Article  PubMed  Google Scholar 

  14. Mattioli, S., Seregnis, E., & Caperna, L. (2000). BTA Trak combined with urinary cytology is a reliable urinary indicator of recurrent transitional cell carcinoma of the bladder. International Journal of Biological Markers, 15, 219–225.

    CAS  PubMed  Google Scholar 

  15. Miyanaga, N., Akaza, H., & Tsukamoto, S. (2003). Usefulness of urinary NMP22 to detect tumor recurrence of superficial bladder cancer after transurethral resection. International Journal of Clinical Oncology, 8, 369–373.

    Article  CAS  PubMed  Google Scholar 

  16. Lahme, S., Bichler, K. H., Feil, G., Zumbragel, A., & Gotz, T. (2003). Comparison of cytology and nuclear matrix protein 22 (NMP22) for detection and follow-up of bladder-cancer. Advanced Experimental Medicine Biology, 539, 111–119.

    Google Scholar 

  17. Ponsky, L. E., Sharma, S., Pandrangi, L., Kedia, S., Nelson, D., Agarwal, A., et al. (2001). Screening and monitoring for bladder cancer, refining the use of NMP22. Journal of Urology, 166(1), 75–78.

    Article  CAS  PubMed  Google Scholar 

  18. Grossman, H., Messing, E., Soloway, M., Tomera, K., Katz, G., Berger, Y., et al. (2005). Detection of bladder cancer using a point-of-care proteomic assay. JAMA, 293, 810–816.

    Article  CAS  PubMed  Google Scholar 

  19. Mian, C., Pycha, A., Wiener, H., et al. (1999). Immunocyt: A new tool for detecting transitional cell cancer of the urinary tract. Journal of Urology, 161, 1486–1489.

    Article  CAS  PubMed  Google Scholar 

  20. Halling, K. C., King, W., Sokolova, I. A., Meyer, R. G., Burkhardt, H. M., Halling, A. C., et al. (2000). A comparison of cytology an fluorescence in situ hybridization for the detection of urothelial carcinoma. Journal of Urology, 164, 1768–1775.

    Article  CAS  PubMed  Google Scholar 

  21. Höglund, M. (2012). The bladder cancer genome, chromosomal changes as prognostic makers, opportunities, and obstacles. Urology Oncology, 30, 533–540.

    Article  Google Scholar 

  22. Jebar, A. H., Hurst, C. D., Tomlinson, D. C., Johnston, C., Taylor, C. F., & Knowles, M. A. (2005). FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma. Oncogene, 24(33), 5218–5225.

    Article  CAS  PubMed  Google Scholar 

  23. Tomlinson, D. C., Baldo, O., Harnden, P., & Knowles, M. A. (2007). FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer. Journal of Pathology, 213(1), 91–98.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  24. Cordon-Cardo, C. (2008). Molecular alterations associated with bladder cancer initiation and progression. Scand Journal of Urology and Nephrology, 42, 154–165.

    Article  Google Scholar 

  25. Puzio-Kuter, A. M., Castillo-Martin, M., Kinkade, C. W., Wang, X., Shen, T. H., Matos, T., et al. (2009). Inactivation of p53 and Pten promotes invasive bladder cancer. Genes & Development, 23(6), 675–680.

    Article  CAS  Google Scholar 

  26. Habuchi, T., Devlin, J., Elder, P. A., & Knowles, M. A. (1995). Detailed deletion mapping of chromosome 9q in bladder cancer, evidence for two tumour suppressor loci. Oncogene, 11, 1671–1674.

    CAS  PubMed  Google Scholar 

  27. Kimura, F., Florl, A. R., Seifert, H. H., Louhelainen, J., Maas, S., Knowles, M. A., & Schulz, W. A. (2001). Destabilization of chromosome 9 in transitional cell carcinoma of the urinary bladder. British Journal of Cancer, 85(12), 887–893.

    Article  Google Scholar 

  28. Scaravilli, M., Asero, P., Visakorpi, T., & Saramäki, O. R. (2014). Mapping of the chromosomal amplification 1p21-22 in bladder cancer. BMC Research Notes, 7, 547.

    Article  PubMed Central  PubMed  Google Scholar 

  29. Chan, M. W., Chan, L. W., Tang, N. L., Tong, J. H., Lo, K. W., Lee, T. L., et al. (2002). Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients. Clinical Cancer Research, 8(2), 464–470.

    CAS  PubMed  Google Scholar 

  30. Friedrich, M. G., Weisenberger, D. J., Cheng, J. C., Chandrasoma, S., Siegmund, K. D., Gonzalgo, M. L., et al. (2004). Detection of methylated apoptosis-associated genes in urine sediments of bladder cancer patients. Clinical Cancer Research, 10(22), 7457–7465.

    Article  CAS  PubMed  Google Scholar 

  31. Dulaimi, E., Uzzo, R. G., Greenberg, R. E., Al-Saleem, T., & Cairns, p. (2004). Detection of bladder cancer in urine by a tumor suppressor gene hypermethylation panel. Clinical Cancer Research, 10(6), 1887–1893.

    Article  CAS  PubMed  Google Scholar 

  32. Reinert, T. (2012). Methylation markers for urine-based detection of bladder cancer, the next generation of urinary markers for diagnosis and surveillance of bladder cancer. Advance Urology, 2012, 503271.

    Google Scholar 

  33. Phe, V., Cussenot, O., & Roupret, m. (2009). Interest of methylated genes as biomarkers in urothelial cell carcinomas of the urinary tract. British Journal of Urology International, 104(7), 896–901.

    Article  CAS  Google Scholar 

  34. Scher, M. B., Elbaum, M. B., Mogilevkin, Y., Hilbert, D. W., Mydlo, J. H., Sidi, A. A., et al. (2012). Detecting DNA methylation of the BCL2, CDKN2A and NID2 genes in urine using a nested methylation specific polymerase chain reaction assay to predict bladder cancer. Journal of Urology, 188(6), 2101–2107.

    Article  CAS  PubMed  Google Scholar 

  35. Catto, J. W., Alcaraz, A., Bjartell, A. S., De Vere, White R., Evans, C. P., Fussel, S., et al. (2011). MicroRNA in prostate, bladder, and kidney cancer, a systematic review. European Urology, 59(5), 671–681.

    Article  CAS  PubMed  Google Scholar 

  36. Dyrskjot, L., Ostenfeld, M. S., Bramsen, J. B., Silahtaroglu, A. N., Lamy, P., Ramanathan, R., et al. (2009). Genomic profiling of microRNAs in bladder cancer, miR-129 is associated with poor outcome and promotes cell death in vitro. Cancer Research, 69(11), 4851–4860.

    Article  CAS  PubMed  Google Scholar 

  37. Han, Y., Chen, J., Zhao, X., Liang, C., Wang, Y., Sun, L., et al. (2011). MicroRNA expression signatures of bladder cancer revealed by deep sequencing. PLoS One, 6(3), e18286.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  38. Puerta-Gil, P., Garcia-Baquero, R., Jia, A. Y., Ocana, S., Alvarez- Mugica, M., Alvarez-Ossorio, J. L., et al. (2012). miR-143, miR-222, and miR-452 are useful as tumor stratification and noninvasive diagnostic biomarkers for bladder cancer. American Journal of Pathology, 180(5), 1808–1815.

    Article  CAS  PubMed  Google Scholar 

  39. Yamada, Y., Enokida, H., Kojima, S., Kawakami, K., Chiyomaru, T., Tatarano, S., et al. (2011). MiR-96 and miR-183 detection in urine serve as potential tumor markers of urothelial carcinoma, correlation with stage and grade, and comparison with urinary cytology. Cancer Science, 102(3), 522–529.

    Article  CAS  PubMed  Google Scholar 

  40. Hanke, M., Hoefig, K., Merz, H., Feller, A. C., Kausch, I., Jocham, D., et al. (2010). A robust methodology to study urine microRNA as tumor marker, microRNA-126 and microRNA-182 are related to urinary bladder cancer. Urology Oncology, 28(6), 655–661.

    Article  CAS  Google Scholar 

  41. Miah, S., Dudziec, E., Drayton, R. M., Zlotta, A. R., Morgan, S. L., Rosario, D. J., et al. (2012). An evaluation of urinary microRNA reveals a high sensitivity for bladder cancer. British Journal of Cancer, 107(1), 123–128.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  42. Mayer, P., Mayer, B., & Mayer, G. (2012). Systems biology, building a useful model from multiple markers and profiles. Nephrology Dial Transplant, 27, 3995–4002.

    Article  CAS  Google Scholar 

  43. Besaratinia, A., Cockburn, M., & Tommasi, S. (2013). Alterations of DNA methylome in human bladder cancer. Epigenetics, 8(10), 1013–1022.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  44. Chihara, Y., Kanai, Y., Fujimoto, H., Sugano, K., Kawashima, K., et al. (2013). Diagnostic markers of urothelial cancer based on DNA methylation analysis. BMC Cancer, 13, 275.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  45. Weiss, G. J., Liang, W. S., Demeure, M. J., Kiefer, J. A., Hostetter, G., et al. (2013). A pilot study using next-generation sequencing in advanced cancers, feasibility and challenges. PLoS One, 8, e76438.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  46. Alberice, J. V., Amaral, A. F. S., Armitage, E. G., Lorente, J. A., Algaba, F., et al. (2013). Searching for urine biomarkers of bladder cancer recurrence using a liquid chromatography-mass spectrometry and capillary electrophoresis-mass spectrometry metabolomics approach. Journal of Chromatography A, 1318, 163–170.

    Article  CAS  PubMed  Google Scholar 

  47. GeneCards (2013) The Human Gene Compendium. Crown Hum Genome Center, Dep Mol Genet Weizmann Institute of Science.

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jantai He.

Additional information

Xiaoying Zhang and Conghui Han contributed equally as co-first authors.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhang, X., Han, C. & He, J. Recent Advances in the Diagnosis and Management of Bladder Cancer. Cell Biochem Biophys 73, 11–15 (2015). https://doi.org/10.1007/s12013-015-0632-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12013-015-0632-6

Keywords

Navigation