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Role of ω-3 Fatty Acids in Cardiovascular Disease

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Abstract

There is a large and increasing global burden of cardiovascular disease (CVD). The Indian subcontinent may be one of the regions with the highest burden of CVD in the world. With affluence and urbanization, fat intake, especially saturated fat, is increasing. Vitamins have beneficial effects which are useful to the heart, but do not provide the all-round cardioprotection that is required. Hence, there is a perceived need of nutritional supplement that is rich in these essential nutrients. Studies have shown multifactorial cardio-protective actions of ω-3 fatty acids. A cardioceutical contains all the essential nutrients, vitamins, and minerals including ω-3 fatty acids in the right proportion that will provide all-round protection to the heart.

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References

  1. Yusuf, S., Reddy, S., Ounpuu, S., & Anand, S. (2001). Global burden of cardiovascular diseases part I: General considerations, the epidemiologic transition, risk factors, and impact of urbanization. Circulation, 104, 2746–2753.

    Article  CAS  PubMed  Google Scholar 

  2. Goyal, A., & Yusuf, S. (2006). The burden of cardiovascular disease in the Indian subcontinent. Indian Journal of Medical Research, 124, 235–244.

    PubMed  Google Scholar 

  3. Shah, B., & Mathur, P. (2010). Surveillance of cardiovascular disease risk factors in India: The need & scope. Indian Journal of Medical Research, 132, 634–642.

    PubMed Central  PubMed  Google Scholar 

  4. Goenka, S., Prabhakaran, D., Ajay, V. S., & Reddy, K. S. (2009). Preventing cardiovascular disease in India—translating evidence to action. Current Science, 97, 367–377.

    Google Scholar 

  5. Misra, A., Sharma, R., Pandey, R. M., & Khanna, N. (2001). Adverse profile of dietary nutrients, anthropometry and lipids in urban slum dwellers of northern India. European Journal of Clinical Nutrition, 55, 727–734.

    Article  CAS  PubMed  Google Scholar 

  6. Hu, F. B., Manson, J. E., & Willett, W. C. (2001). Types of dietary fat and risk of coronary heart disease: A critical review. American Journal of Clinical Nutrition, 20, 5–19.

    Article  Google Scholar 

  7. Greiner, R., Konietzny, U., & Jany, K.-D. (2006). Phytate—an undesirable constituent of plant-based foods? Journal für Ernährungsmedizin, 8(3), 18–28.

    Google Scholar 

  8. Jonnalagadda, S. S., & Diwan, S. (2002). Nutrient intake of first generation Gujarati Asian Indian immigrants in the U.S. Journal of the American College of Nutrition, 21, 372–380.

    Article  CAS  PubMed  Google Scholar 

  9. Kris-Etherton, P. M., Hu, F. B., Ros, E., & Sabaté, J. (2008). The role of tree nuts and peanuts in the prevention of coronary heart disease: Multiple potential mechanisms. Journal of Nutrition, 138, 1746S–1751S.

    CAS  PubMed  Google Scholar 

  10. Lichtenstein, A. H. (2009). Nutrient supplements and cardiovascular disease: A heartbreaking story. Journal of Lipid Research, 50(Suppl), S429–S433.

    PubMed Central  PubMed  Google Scholar 

  11. Morris, C. D., & Carson, S. (2003). Routine vitamin supplementation to prevent cardiovascular disease: A summary of the evidence for the U.S. Preventive Services Task Force. Annals of Internal Medicine, 139, 56–70.

    Article  CAS  PubMed  Google Scholar 

  12. Galan, P., Kesse-Guyot, E., Czernichow, S., Briancon, S., Blacher, J., Hercberg, S., & SU.FOL.OM3 Collaborative Group. (2010). Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: A randomised placebo controlled trial. BMJ, 341, c6273.

    Article  PubMed Central  PubMed  Google Scholar 

  13. Carrero, J. J., Fonollá, J., Marti, J. L., Jiménez, J., Boza, J. J., & López-Huertas, E. (2007). Intake of fish oil, oleic acid, folic acid, and vitamins B-6 and E for 1 year decreases plasma C-reactive protein and reduces coronary heart disease risk factors in male patients in a cardiac rehabilitation program. Journal of Nutrition, 137, 384–390.

    CAS  PubMed  Google Scholar 

  14. Mozaffarian, D., Ascherio, A., Hu, F. B., Stampfer, M. J., Willett, W. C., Siscovick, D. S., et al. (2005). Interplay between different polyunsaturated fatty acids and risk of coronary heart disease in men. Circulation, 111, 157–164.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  15. Wijendran, V., & Hayes, K. C. (2004). Dietary n-6 and n-3 fatty acid balance and cardiovascular health. Annual Review of Nutrition, 24, 597–615.

    Article  CAS  PubMed  Google Scholar 

  16. Simopoulos, A. P. (2008). The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Experimental Biology and Medicine, 233, 674–688. (Maywood).

    Article  CAS  PubMed  Google Scholar 

  17. Sudha, V., Radhika, G., & Mohan, V. (2004). Current trends in the management of diabetes. Indian Journal of Medical Research, 120, 4–8.

    CAS  PubMed  Google Scholar 

  18. Bamji, M. S. (2006). Omega-3 fatty acids in the diet. Current Science, 90, 1590–1591.

    Google Scholar 

  19. Singh, M. (2005). Essential fatty acids, DHA and human brain. Indian Journal of Pediatrics, 72, 239–242.

    Article  PubMed  Google Scholar 

  20. Misra, A., Khurana, L., Isharwal, S., & Bhardwaj, S. (2008). South Asian diets and insulin resistance. British Journal of Nutrition, 101, 1–9.

    Google Scholar 

  21. Kandasamy, N., Joseph, F., & Goenka, N. (2008). The role of omega-3 fatty acids in cardiovascular disease, hypertriglyceridaemia and diabetes mellitus. British Journal of Diabetes and Vascular Disease, 8, 121–128.

    Article  CAS  Google Scholar 

  22. Covington, M. B. (2004). Omega-3 Fatty Acids. American Family Physician, 70, 133–140.

    PubMed  Google Scholar 

  23. Lee, J. H., O’Keefe, J. H., Lavie, C. J., Marchioli, R., & Harris, W. S. (2008). Omega-3 Fatty acids for cardioprotection. Mayo Clinic Proceedings, 83, 324–332.

    Article  CAS  PubMed  Google Scholar 

  24. Albert, C. M., Hennekens, C. H., O’Donnell, C. J., Ajani, U. A., Carey, V. J., Willett, W. C., et al. (1998). Fish consumption and risk of sudden cardiac death. JAMA, 279, 23–28.

    Article  CAS  PubMed  Google Scholar 

  25. Hu, F. B., Bronner, L., Willett, W. C., Stampfer, M. J., Rexrode, K. M., Albert, C. M., et al. (2002). Fish and omega-3 fatty acid intake and risk of coronary heart disease in women. JAMA, 287, 1815–1821.

    Article  CAS  PubMed  Google Scholar 

  26. Burr, M. L., Fehily, A. M., Gilbert, J. F., Rogers, S., Holliday, R. M., Sweetnam, P. M., et al. (1989). Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: Diet and reinfarction trial (DART). Lancet, 2, 757–761.

    Article  CAS  PubMed  Google Scholar 

  27. Gazi, I., Liberopoulos, E. N., Saougos, V. G., & Elisaf, M. (2006). Beneficial effects of omega-3 fatty acids: The current evidence. Hellenic Journal of Cardiology, 47, 223–231.

    PubMed  Google Scholar 

  28. Singh, R. B., Niaz, M. A., Sharma, J. P., Kumar, R., Rastogi, V., & Moshiri, M. (1997). Randomized, double-blind, placebo-controlled trial of fish oil and mustard oil in patients with suspected acute myocardial infarction: The Indian experiment of infarct survival–4. Cardiovascular Drug Reviews, 11, 485–491.

    Article  CAS  Google Scholar 

  29. de Lorgeril, M., Salen, P., Martin, J. L., Monjaud, I., Delaye, J., & Mamelle, N. (1999). Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: Final report of the Lyon Diet Heart Study. Circulation, 99, 779–785.

    Article  PubMed  Google Scholar 

  30. GruppoItalianoper lo Studio della Sopravvivenza nell’Infarto miocardico. (1999). Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: Results of the GISSI-Prevenzione trial. Lancet, 354, 447–455.

    Article  Google Scholar 

  31. Yokoyama, M., Origasa, H., Matsuzaki, M., et al. (2007). Japan EPA lipid intervention study (JELIS) Investigators. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): A randomized open-label, blinded endpoint analysis. Lancet, 369, 1090–1098.

    Article  CAS  PubMed  Google Scholar 

  32. Harris, W. S. (1997). N-3 fatty acids and serum lipoproteins: Human studies. American Journal of Clinical Nutrition, 65, 1645S–1654S.

    CAS  PubMed  Google Scholar 

  33. Durrington, P. N., Bhatnagar, D., Mackness, M. I., Morgan, J., Julier, K., Khan, M. A., et al. (2001). An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia. Heart, 85, 544–548.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  34. Morris, M. C., Sacks, F., & Rosner, B. (1993). Does fish oil lower blood pressure? A meta-analysis of controlled trials. Circulation, 88, 523–533.

    Article  CAS  PubMed  Google Scholar 

  35. Appel, L. J., Miller, E. R., Seidler, A. J., & Whelton, P. K. (1993). Does supplementation of diet with ‘fish oil’ reduce blood pressure? A meta-analysis of controlled clinical trials. Archives of Internal Medicine, 153, 1429–1438.

    Article  CAS  PubMed  Google Scholar 

  36. O’Keefe, J. H, Jr, Abuissa, H., Sastre, A., Steinhaus, D. M., & Harris, W. S. (2006). Effects of omega-3 fatty acids on resting heart rate, heart rate recovery after exercise, and heart rate viability in men with healed myocardial infarctions and depressed ejection fractions. American Journal of Cardiology, 97, 1127–1130.

    Article  PubMed  Google Scholar 

  37. Geelen, A., Brouwer, I. A., Schouten, E. G., Maan, A. C., Katan, M. B., & Zock, P. I. (2005). Effects of n-3 fatty acids from fish on premature ventricular complexes and heart rate in humans. American Journal of Clinical Nutrition, 81, 416–420.

    CAS  PubMed  Google Scholar 

  38. Mozaffarian, D., Prineas, R. J., Stein, P. K., & Siscovick, D. S. (2006). Dietary fish and n-3 fatty acid intake and cardiac electrocardiographic parameters in humans. Journal of the American College of Cardiology, 48, 478–484.

    Article  CAS  PubMed  Google Scholar 

  39. Mozaffarian, D., Bryson, C. L., Lemaitre, R. N., Burke, G. L., & Siscovick, D. S. (2005). Fish intake and risk of incident heart failure. Journal of the American College of Cardiology, 45, 2015–2021.

    Article  CAS  PubMed  Google Scholar 

  40. Yamagishi, K., Nettleton, J. A., & Folsom, A. R. (2008). Plasma fatty acid composition and incident heart failure in middle-aged adults: The Atherosclerosis Risk In Communities (ARIC) study. American Heart Journal, 156, 965–974.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  41. Tavazzi, L., Maggioni, A. P., Marchioli, R., Barlera, S., Franzosi, M. G., Latini, R., et al. (2008). GISSI-HF Investigators. Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): A randomised, double-blind, placebo-controlled trial. Lancet, 372, 1223–1230.

    Article  PubMed  Google Scholar 

  42. Eid, H. M., Arnesen, H., Hjerkinn, E. M., Lyberg, T., Ellingsen, I., & Seljeflot, I. (2006). Effect of diet and omega-3 fatty acid intervention on asymmetric dimethylarginine. Journal of Nutrition and Metabolism (Lond), 3, 4.

    Article  Google Scholar 

  43. Robinson, J. G., & Stone, N. J. (2006). Antiatherosclerotic and antithrombotic effects of omega-3 fatty acids. American Journal of Cardiology, 98, 39i.

    Article  CAS  PubMed  Google Scholar 

  44. James, M. J., Gibson, R. A., & Cleland, L. G. (2000). Dietary polyunsaturated fatty acids and inflammatory mediator production. American Journal of Clinical Nutrition, 71, 343S.

    CAS  PubMed  Google Scholar 

  45. Lopez-Garcia, E., Schulze, M. B., Manson, J. E., et al. (2004). Consumption of (n-3) fatty acids is related to plasma biomarkers of inflammation and endothelial activation in women. Journal of Nutrition, 134, 1806–1811.

    CAS  PubMed  Google Scholar 

  46. Von Schacky, C., Angerer, P., Kothny, W., et al. (1999). The effect of dietary omega-3 fatty acids on coronary atherosclerosis. A randomized, double-blind, placebo-controlled trial. Annals of Internal Medicine, 130, 554.

    Article  Google Scholar 

  47. Angerer, P., Kothny, W., Stork, S., & von Schacky, C. (2002). Effect of dietary supplementation with omega-3 fatty acids on progression of atherosclerosis in carotid arteries. Cardiovascular Research, 54, 183.

    Article  CAS  PubMed  Google Scholar 

  48. Mita, T., Watada, H., Ogihara, T., Nomiyama, T., Ogawa, O., Kinoshita, J., et al. (2007). Eicosapentaenoic acid reduces the progression of carotid intima-media thickness in patients with type 2 diabetes. Atherosclerosis, 191, 162–167.

    Article  CAS  PubMed  Google Scholar 

  49. Calder, P. C. (2004). N–3 Fatty acids and cardiovascular disease: Evidence explained and mechanisms explored. Clinical Science, 10, 1–11.

    Google Scholar 

  50. Kris-Etherton, P. M., Harris, W. S., & Appel, L. J. (2002). American Heart Association. Nutrition Committee. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation, 106, 2747–2757.

    Article  PubMed  Google Scholar 

  51. Schwalfenberg, G. (2006). Omega-3 fatty acids: Their beneficial role in cardiovascular health. Canadian Family Physician, 52, 734–740.

    PubMed Central  PubMed  Google Scholar 

  52. Patel, J. V., Tracey, I., Hughes, E. A., & Lip, G. Y. (2009). Omega-3 polyunsaturated fatty acids: A necessity for a comprehensive secondary prevention strategy. Vascular Health and Risk Management, 5, 801.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

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  1. Department of Cardiology, Xuzhou Central Hospital, 199# South Jiefang Road, Xuzhou, 221009, Jiangsu, China

    Pei-Ying Zhang

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Zhang, PY. Role of ω-3 Fatty Acids in Cardiovascular Disease. Cell Biochem Biophys 72, 869–875 (2015). https://doi.org/10.1007/s12013-015-0554-3

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