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Effect of SNP Polymorphisms of EDN1, EDNRA, and EDNRB Gene on Ischemic Stroke

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Abstract

The objective of this study is to investigate the association between SNP polymorphisms of endothelin-1 (EDN1) and endothelin receptor (EDNRA and EDNRB) gene and ischemic stroke (IS) in the Chinese Han population in northern. A case–control study was introduced. We genotyped eight SNPs (rs1800541, rs2070699, and rs5370 in EDN1 gene; rs1801708, rs5333, and rs5335 in EDNRA gene; and rs3818416 and rs5351 in EDNRB gene) and calculated their polymorphic distribution in control group, IS group, and the IS subgroups. In male population, EDN1 gene rs2070699 G allele increased the incidence risk to 1.78 times (P = 0.009; OR 1.78; 95 % CI 1.15–2.75) and the risk of morbidity of rs5370 T allele carrying increased to 1.49 times (P = 0.048; OR 1.49; 95 % CI 1.00–2.21). EDNRA gene mutation rs5335 homozygous CC morbidity risk was significantly lower (P = 0.016; OR 0.52; 95 % CI 0.31–0.88). In the female population, the mutant homozygous AA cancer risk was significantly higher than G allele carriers (P = 0.019; OR 2.65; 95 % CI 1.18–6.00) on EDNRA gene rs1801708. In EDN1 gene, T allele of rs5370 and G allele of rs2070699 may be IS incidence risk factors in Northern Han male population. A allele of rs1801708 in EDNRA gene can increase the risk of IS in Northern Han women population.

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Authors and Affiliations

  1. School of Nursing, Liaoning Medical College, Jinzhou, China

    Lei Zhang

  2. Department of Neurology, The First Affiliated Hospital of Liaoning Medical College, Renmin Street, No. 2, Fifth Duan, Jinzhou, 121001, China

    Rubo Sui

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  1. Lei Zhang
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  2. Rubo Sui
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Correspondence to Rubo Sui.

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Zhang, L., Sui, R. Effect of SNP Polymorphisms of EDN1, EDNRA, and EDNRB Gene on Ischemic Stroke. Cell Biochem Biophys 70, 233–239 (2014). https://doi.org/10.1007/s12013-014-9887-6

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  • DOI: https://doi.org/10.1007/s12013-014-9887-6

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