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Cross-Talk Between Selenium Nanoparticles and Cancer Treatment Through Autophagy

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Abstract

Autophagy is commonly referred as self-eating and a complex cellular process that is involved in the digestion of protein and damaged organelles through a lysosome-dependent mechanism, and this mechanism is essential for maintaining proper cellular homeostasis. Selenium is a vital trace element that plays essential functions in antioxidant defense, redox state control, and range of particular metabolic processes. Selenium nanoparticles have become known as a promising agent for biomedical use, because of their high bioavailability, low toxicity, and degradability. However, and in recent years, they have attracted the interest of researchers in developing anticancer nano-drugs. Selenium nanoparticles can be used as a potential therapeutic agent or in combination with other agents to act as carriers for the development of new treatments. More intriguingly, selenium nanoparticles have been extensively shown to impact autophagy signaling, allowing selenium nanoparticles to be used as possible cancer treatment agents. This review explored the connections between selenium and autophagy, followed by developments and current advances of selenium nanoparticles for autophagy control in various clinical circumstances. Furthermore, this study examined the functions and possible processes of selenium nanoparticles in autophagy regulation, which may help us understand how selenium nanoparticles regulate autophagy for the potential cancer treatment.

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The authors confirm that data sharing is not applicable to this article as no new data were created or analyzed in this study.

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Funding

This research was funded by the National Natural Science Foundation of China (grant numbers 31702305, 31872533, 32072933), and a Project Funded by Jiangsu Higher Education Institutions Priority Academic Program Development (PAPD).

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  1. Waseem Ali, Yan Chen, Zongping Liu and Hui Zou contributed equally to this work.

Authors and Affiliations

  1. College of Veterinary Medicine, Yangzhou University Yangzhou, Yangzhou, Jiangsu, 225009, People’s Republic of China

    Waseem Ali, Yan Chen, Jameel Ahmed Gandahi, Izhar Hyder Qazi, Jian Sun, Tao Wang, Zongping Liu & Hui Zou

  2. Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, 225009, People’s Republic of China

    Waseem Ali, Yan Chen, Jameel Ahmed Gandahi, Izhar Hyder Qazi, Jian Sun, Tao Wang, Zongping Liu & Hui Zou

  3. Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, 225009, People’s Republic of China

    Waseem Ali, Yan Chen, Jameel Ahmed Gandahi, Izhar Hyder Qazi, Jian Sun, Tao Wang, Zongping Liu & Hui Zou

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Ali, W., Chen, Y., Gandahi, J.A. et al. Cross-Talk Between Selenium Nanoparticles and Cancer Treatment Through Autophagy. Biol Trace Elem Res 202, 2931–2940 (2024). https://doi.org/10.1007/s12011-023-03886-8

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