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Genotoxicity of Copper, Silver and Green Synthetic Gold Nanoparticles in Fish (Ctenopharyngodon idella)

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Abstract

Grass carp (Ctenopharyngodon idella) was exposed to nanoparticles of different concentrations, i.e., copper oxide nanoparticles (CuO-NPs), silver nanoparticles (Ag-NPs), and green synthetic gold nanoparticles (Au-NPs).The administered doses of the three concentration groups were 20mg L−1, 30 mg L−1, and 40mg L−1 each for a period of 14 and 28 days, respectively. The DNA damage in the erythrocytes of grass carp was detected through a comet assay technique. The values of total comet score (TCS) were noted for the exposed concentrations with a significant increasing trend (p < 0.05) and ordered as CuO-NPs > Ag-NPs > Au-NPs. The highest TCS value of the exposed erythrocytes was recorded for CuO-NPs at 40 mg L−1 after 14 days of exposition period. Comparatively, TCS values of erythrocytes exposed to green synthetic Au-NPs at all the concentrations and exposed time were less as compared to the Ag-NPs and CuO-NPs. The study confirmed the adverse effects of nanoparticles on the genetic material of fish cells.

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Data Availability

The data that support the findings of this study are available from the corresponding author, [Shah N], upon reasonable request.

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Authors and Affiliations

  1. Department of Zoology, University of Peshawar, Peshawar, Khyber Pakhtunkhwa, Pakistan

    Ajmal Khan, Maghfoor Khan, Abidullah Dawar, Ashraf Ali Shah & Muhammad Khisroon

  2. Department of Zoology, Kohat University of Science and Tehnology, Kohat, Khyber Pakhtunkhwa, Pakistan

    Farmanullah Dawar

  3. Department of Zoology, University of Swabi, Swabi, Khyber Pakhtunkhwa, Pakistan

    Nazish Shah

  4. Department of Chemistry, Kohat University of Science and Tehnology, Kohat, Khyber Pakhtunkhwa, Pakistan

    Mansoor Khan

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  1. Ajmal Khan
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  2. Maghfoor Khan
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  3. Nazish Shah
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  4. Mansoor Khan
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  5. Abidullah Dawar
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  6. Ashraf Ali Shah
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  7. Farmanullah Dawar
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  8. Muhammad Khisroon
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Contributions

Conceptualization, Data curation, AK; MKa; investigation, MK;b ;AD; FUD, AAS; Methodology, MKa; Writing—original draft, N.S.; Supervision, M.Kc.

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Correspondence to Nazish Shah.

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Ethical approval for the study was taken from the Ethical Committee, University of Peshawar.

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Khan, A., Khan, M., Shah, N. et al. Genotoxicity of Copper, Silver and Green Synthetic Gold Nanoparticles in Fish (Ctenopharyngodon idella). Biol Trace Elem Res 202, 2855–2863 (2024). https://doi.org/10.1007/s12011-023-03877-9

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  • DOI: https://doi.org/10.1007/s12011-023-03877-9

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