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Serum Copper/Zinc Ratio in Overweight and Obese Children: a Cross-Sectional Study

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Abstract

To assess the association between serum copper/zinc ratio (CZR) and overweight/obesity in children. Sociodemographic and clinical data of children aged 8–18 years old were extracted from the National Health and Nutrition Examination Survey (NHANES) database in this cross-sectional study. These associations were explored using weighted univariate and multivariate logistic regression analyses with the odds ratios (ORs) and 95% confidence intervals (CIs). High serum CZR level was related to higher odds of overweight (OR = 1.74), obesity (OR = 5.26), and central obesity (OR = 2.99). Subgroup analyses showed that high serum CZR levels were associated with high odds of overweight in children aged ≥ 12 years old (OR = 2.19) and females (OR = 2.02), while the increased odds of obesity and central obesity were found in children aged ≥ 12 years old and both male and female. Elevated serum CZR level was linked to high odds of childhood overweight, obesity, and central obesity, and this relationship was also found in children with different age and gender.

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Data Availability

The datasets generated during and/or analyzed during the current study are available in the NHANES database, https://www.cdc.gov/nchs/nhanes/index.htm.

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Funding

This study was supported by China International Medical Foundation Pediatric Endocrinology young and middle-aged physicians growth research fund project (NO: Z-2019- 41-2101- 01).

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Authors and Affiliations

  1. Department of Endocrinology, Children’s Hospital of Capital Institute of Pediatrics, No. 2 Yabao Road, Chaoyang District, 100020, Beijing, People’s Republic of China

    Mu Du, Mingfang Qiu, Ye Qian, Tianqi Wang & Xiaobo Chen

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  1. Mu Du
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  2. Mingfang Qiu
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  3. Ye Qian
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  4. Tianqi Wang
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  5. Xiaobo Chen
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Contributions

MD and XC designed the study. MD wrote the manuscript. MQ, YQ, and TW collected, analyzed, and interpreted the data. XC critically reviewed, edited, and approved the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Xiaobo Chen.

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The data were deidentified, and all the participants provided informed consent. No ethical approval of our agency’s IRB was required since this survey was publicly available.

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Du, M., Qiu, M., Qian, Y. et al. Serum Copper/Zinc Ratio in Overweight and Obese Children: a Cross-Sectional Study. Biol Trace Elem Res 202, 1539–1549 (2024). https://doi.org/10.1007/s12011-023-03790-1

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