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Comparison of Nutritional Availability of Biogenic Selenium Nanoparticles and Chemically Synthesized Selenium Nanoparticles

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Abstract

Selenium (Se) is an essential micronutrient, and animals biosynthesize selenoproteins from various selenocompounds such as inorganic salts and organic selenocompounds as a Se source. In addition to the inorganic and organic forms of Se, it is also known that elemental Se is biologically synthesized at the nanoscale in nature. Biologically synthesized Se nanoparticles (Se-NPs), i.e., biogenic Se-NPs (Se-BgNPs), have not been fully investigated as a Se source compared with the other forms of Se. In this study, we evaluated the nutritional availability of Se-BgNPs biosynthesized in E. coli and revealed that Se-BgNPs were less assimilated into selenoproteins in rats as a Se source than inorganic Se salt or chemically synthesized Se-NPs. Se-BgNPs showed tolerance toward digestion and low absorbability in gut, which resulted in the low nutritional availability. Se-BgNPs seem to be coated with a biomaterial that functions to reduce their toxicity toward E. coli and at the same time lowers their availability to animals.

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Data Availability

The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.

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Acknowledgements

We thank Dr. Daiki Fujioka, Japan Synchrotron Radiation Institute, for technical assistance in SEM analysis.

Funding

This study was supported by JSPS KAKENHI Grants (Numbers 19H01081, 19H05772, 20J10577, 20H02907, 20J40237, 21H04920, and 22H04823) and by the Institute for Fermentation, Osaka (Grant number G-2019–2-055).

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Authors and Affiliations

  1. Laboratory of Toxicology and Environmental Health, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo, Chiba, 260-8675, Japan

    Kazuaki Takahashi & Yasumitsu Ogra

  2. Graduate School of Horticulture, Chiba University, Inage, Chiba, 263-8522, Japan

    Kazuaki Takahashi

  3. Laboratory of Applied Molecular Microbiology, College of Life Sciences, Ritsumeikan University, Kusatsu, Shiga, 525-8577, Japan

    Anna Ochi & Hisaaki Mihara

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  1. Kazuaki Takahashi
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Contributions

The manuscript was written through contributions of all authors. All authors have given approval to the final version of the manuscript. Kazuaki Takahashi: conceptualization, methodology, investigation, writing—original draft, writing—review and editing, and funding acquisition. Anna Ochi: methodology, investigation, conceptualization, writing—review and editing, and funding acquisition. Hisaaki Mihara: conceptualization, writing—review and editing, and funding acquisition. Yasumitsu Ogra: conceptualization, writing—original draft, writing—review and editing, funding acquisition, and supervision.

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Correspondence to Yasumitsu Ogra.

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All animal experiments were approved by the Animal Investigation Committee of Chiba University.

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Takahashi, K., Ochi, A., Mihara, H. et al. Comparison of Nutritional Availability of Biogenic Selenium Nanoparticles and Chemically Synthesized Selenium Nanoparticles. Biol Trace Elem Res 201, 4861–4869 (2023). https://doi.org/10.1007/s12011-023-03567-6

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