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Enzyme PTP-1B Inhibition Studies by Vanadium Metal Complexes: a Kinetic Approach

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Abstract

The medical field now needs more novel drugs to treat obesity and type-2 diabetes mellitus (T2D) than ever before. Obesity and T2D are both characterized by resistance to the hormones leptin and insulin. PTP-1B is a promising target for drug growth, as strong genetic, pharmacological, and biochemical evidence points to the possibility of treating diabetes and obesity by blocking the PTP-1B enzyme. Studies have also found that PTP-1B is overexpressed in patients with diabetes and obesity, suggesting that inhibiting PTP-1B may be a useful technique in their care. There are no clinically used PTP-1B inhibitors, despite the fact that numerous naturally occurring PTP-1B inhibitors have demonstrated great therapeutic promise. This is most likely due to their low activity or lack of selectivity. It is still important to look for more effective and focused PTP-1B inhibitors. A few organovanadium metal complexes were synthesized and characterized, and binding studies on vanadium complexes with PTP-B were also performed using fluorescence emission spectroscopy. Additionally, we theoretically (molecular modeling) and experimentally (enzyme kinetics) examined the PTP-1B inhibitory effects of these vanadium metal complexes and found that they have excellent PTP-1B inhibitory properties.

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Acknowledgements

The authors would like to thank the Head of the Chemistry Department at Osmania University in India for providing the resources required to conduct the current study, as well as DST in India for financial assistance. We are grateful to the University Grants Commission, India, for funding under the Basic Scientific Research Fellowship (BSR) scheme with file number F.4-1/2006(BSR)11-38/2008(BSR)/2013-2014/01.

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Authors and Affiliations

  1. Department of Chemistry, Osmania University, Hyderabad, Telangana, 500007, India

    Ayub Shaik & Deva Das Manwal

  2. Department of Chemistry, Tara Government College (A), Sangareddy, Telangana, India

    Vani Kondaparthy

  3. Department of Chemistry, Telangana Mahila Vishwavidyalaya, Hyderabad, Telangana, India

    Alia Begum & Ameena Husain

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Contributions

AyubShaik: validation, investigation—formal analysis, writing—original draft, and data curation. Vani Kondaparthy: data curation and formal analysis. Aliya Begum: writing—review and editing. Ameena Husain: investigation and methodology. Deva Das Manwal: conceptualization, methodology, validation, resources, and supervision.

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Shaik, A., Kondaparthy, V., Begum, A. et al. Enzyme PTP-1B Inhibition Studies by Vanadium Metal Complexes: a Kinetic Approach. Biol Trace Elem Res 201, 5037–5052 (2023). https://doi.org/10.1007/s12011-023-03557-8

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