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Ferroptosis As a Mechanism for Health Effects of Essential Trace Elements and Potentially Toxic Trace Elements

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Abstract

Ferroptosis is a unique form of programmed cell death driven by iron-dependent phospholipid peroxidation that was proposed in recent years. It plays an important role in processes of various trace element-related diseases and is regulated by redox homeostasis and various cellular metabolic pathways (iron, amino acids, lipids, sugars), as well as disease-related signaling pathways. Some limited pioneering studies have demonstrated ferroptosis as a mechanism for the health effects of essential trace elements and potentially toxic trace elements, with crosstalk among them. The aim of this review is to bring together research articles and identify key direct and indirect evidence regarding essential trace elements (iron, selenium, zinc, copper, chromium, manganese) and potentially toxic trace elements (arsenic, aluminum, mercury) and their possible roles in ferroptosis. Our review may help determine future research priorities and opportunities.

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Funding

This work was supported by the National Natural Science Foundations of China (82003402, 81860569), Guizhou Province Science and Technology Plan Project of China (No. ZK[2021] key 009) and the Excellent Young Talents Plan of Guizhou Medical University (No. [2021]102).

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  1. The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education & School of Public Helath, Guizhou Medical University, Guiyang, 550025, China

    Yuyan Xu, Ruobi Chen & Qibing Zeng

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Yuyan Xu: data collection, data analysis, data curation, writing—original draft, writing—review and editing, visualization, and funding acquisition. Ruobi Chen: data collection, data analysis, data curation, and writing—original draft. Qibing Zeng: design, resources, writing—review and editing, supervision, project administration, and funding acquisition.

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Xu, Y., Chen, R. & Zeng, Q. Ferroptosis As a Mechanism for Health Effects of Essential Trace Elements and Potentially Toxic Trace Elements. Biol Trace Elem Res 201, 4262–4274 (2023). https://doi.org/10.1007/s12011-022-03523-w

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