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Hepatorenal Toxicity of Inorganic Arsenic in White Pekin Ducks and Its Amelioration by Using Ginger

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Abstract

The toxic metalloid arsenic is known to cause liver and kidney injury in many humans and animals. The goal of this paper was to exemplify the antagonism of ginger against arsenic (As)-induced hepato-renal toxicity. In addition, the pathways Nrf2/Keap1 and NF/κB were studied to reveal the molecular mechanism of the stress. One hundred twenty 7-day-old White Pekin ducks were randomly allocated into five groups, having 24 birds in each. Each group contained three replicates having 8 birds in each replicate and maintained for 90 days. The groups were as follows: T-1 [control-basal diet with normal water], T-2 [T1 + As at 28 ppm/L of water], T-3 [T2 + ginger powder at 100 mg/kg feed], T-4 [T2 + ginger powder at 300 mg/kg feed], and T-5 [T2 + ginger powder at 1 g/kg feed]. It was observed that there was a significant increase in oxidative parameters whereas a significant decrease in antioxidant parameters in hepato-renal tissues in T-2. The exposure to As not only decreased the mRNA expression of antioxidant parameters like Nrf2, SOD-1, CAT, GPX, and HO-1and anti-inflammatory markers like IL-4 and IL-10 but also increased the m-RNA expression of NF-κB, Keap-1 and pro-inflammatory markers like IL-2, Il-6, IL-18, IL-1β, and TNF-α. There was also an accumulation of As in hepatic and renal tissue, confirmed by residual analysis of these tissues. By correlating the above parameters, As at 28 ppm showed significant toxic effects, and ginger powder at 1 g/kg feed effectively counteracted the toxic effects of As in ducks.

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Acknowledgements

The authors all wish to acknowledge the Central Avian Research Institute (Bhubaneswar, India) for providing the experimental animal site and ensuring the progress of the scientific experiment smoothly and acknowledge the College of Veterinary Science and Animal Husbandry, Odisha University of Agriculture and Technology (Bhubaneswar, India) for experimental material assistance.

Funding

CARI funded this experiment with project number P-1/2017/1-IAV/L34/6200.

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Authors and Affiliations

  1. Department of Veterinary Clinical Medicine, College of Veterinary Science and Animal Husbandry, Odisha University of Agriculture and Technology, Bhubaneswar, 751003, India

    Santosh Kumar Panda, Geeta Rani Jena & Ramesh Chandra Patra

  2. Regional centre ICAR-Directorate of Poultry Research, Bhubaneswar, 751003, India

    Dhirendra Kumar, Surya Kant Mishra, Bijaya Kumar Swain, Prafulla Kumar Naik & Chandra Kant Beura

  3. Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Odisha University of Agriculture and Technology, Bhubaneswar, 751003, India

    Susen Kumar Panda

  4. Department of Animal Nutrition, College of Veterinary Science and Animal Husbandry, Odisha University of Agriculture and Technology, Bhubaneswar, 751003, India

    Kamdev Sethy

  5. Department of Plant Breeding and Genetics, College of Agriculture, Odisha University of Agriculture and Technology, Bhubaneswar, 751003, India

    Bhagyalaxmi Panda

Authors
  1. Santosh Kumar Panda
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  2. Dhirendra Kumar
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  3. Geeta Rani Jena
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  5. Susen Kumar Panda
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  9. Prafulla Kumar Naik
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  11. Bhagyalaxmi Panda
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Contributions

Geeta Rani Jena, Dhirendra Kumar, Surya Kant Mishra, Bijaya Kumar Swain, Prafulla Kumar Naik, and Chandra Kant Beura designed the experiment; Ramesh Chandra Patra and Susen Kumar Panda provided helpful suggestions; statistical analysis of all data, original draft wrote, and modified were completed by Kamdev Sethy, and Santosh Kumar Panda conducted the animal feeding and the sample analysis; Bhagyalaxmi Panda participated in the sample collection.

Corresponding author

Correspondence to Santosh Kumar Panda.

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Panda, S.K., Kumar, D., Jena, G.R. et al. Hepatorenal Toxicity of Inorganic Arsenic in White Pekin Ducks and Its Amelioration by Using Ginger. Biol Trace Elem Res 201, 2471–2490 (2023). https://doi.org/10.1007/s12011-022-03317-0

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