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Metabolomic Analysis Reveals the Adaptation in the P. przewalskii to Se-Deprived Environment

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Abstract

The Procapra przewalskii inhabits in a selenium (Se)-deprived environment in long-term, but they have no pathological manifestations due to the Se deprivation. This study aimed to reveal the underlying adaptation induced by Se deprivation. In the analysis, a total of 93 significantly changed metabolites were identified in positive and negative ion modes, including 46 upregulated and 47 downregulated compounds in the Se-deprived group. The differential metabolites were annotated as the major molecules in bile acid biosynthesis, biosynthesis of unsaturated fatty acids, and pyrimidine metabolism, respectively. This study systematically analyzed the serum metabolomics characteristics of P. przewalskii under Se-deprived conditions for the first time, providing a basis for further understanding of the metabolic mechanism of P. przewalskii in the Se-deprived environment.

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Funding

This work was supported by the National Natural Science Foundation of China (Grant No:42171060) and the Innovation and Development Supporting Plan Project of Key Industries in Southern Xinjiang (2021DB014).

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Author notes

  1. Qionglian Zhang and Kui Zhao contributed equally to this work.

Authors and Affiliations

  1. School of Life Science and Engineering, Southwest University of Science and Technology, No. 59 Middle Section of Avenue, District, Mianyang, 621010, China

    Qionglian Zhang & Xiaoyun Shen

  2. School of Materials and Architectural Engineering, Guizhou Normal University, Guiyang, 550025, China

    Kui Zhao

  3. World Bank Poverty Alleviation Project Office in Guizhou, Southwest China, Guiyang, 550004, Guizhou, China

    Xiaoyun Shen

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  1. Qionglian Zhang
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  2. Kui Zhao
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  3. Xiaoyun Shen
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Contributions

Conceptualization, QL.Z.; methodology, QL.Z. and K.Z.; software, QL.Z. and K.Z.; validation, QL.Z., K.Z., and XY.S.; formal analysis, QL.Z. and K.Z.; investigation, QL.Z. and XY.S.; resources, QL.Z.; data curation, QL.Z. and K.Z.; writing—original draft preparation, QL.Z., K.Z., and XY.S.; writing—review and editing, QL.Z., K.Z., and XY.S.; visualization, QL.Z. and K.Z.; supervision, QL.Z. and K.Z.; project administration, QL.Z, K.Z., and XY.S.; funding acquisition, XY.S. All authors have read and agreed to the published version of the manuscript.

Corresponding author

Correspondence to Xiaoyun Shen.

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Ethical Standards

All experiments were carried out in accordance with the Guide for the Care and Use of Animals in Agricultural Research and Teaching Consortium (Federation of Animals Science Societies. 2010, Project A00657). The protocol for the present experiment was approved by the Institutional Animal Care and Use Committee of Southwest University of Science and Technology in China. All authors confirm ethical responsibilities.

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Qionglian Zhang and Kui Zhao are co-first authors.

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Zhang, Q., Zhao, K. & Shen, X. Metabolomic Analysis Reveals the Adaptation in the P. przewalskii to Se-Deprived Environment. Biol Trace Elem Res 200, 3608–3620 (2022). https://doi.org/10.1007/s12011-021-02971-0

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