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Administration of Silver Nanoparticles in Diabetes Mellitus: A Systematic Review and Meta-analysis on Animal Studies

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Abstract

Biological features of silver nanoparticles in rising the insulin level of diabetic animal models were considered in recent years, which resulted in decreasing hyperglycemia condition. We reviewed the published literature to investigate the possible role of silver nanoparticles (Ag-NPs) throughout the treatment of diabetes mellitus in animal studies. In this systematic review and meta-analysis, we performed a search throughout the English literature of electronic databases, including Scopus, PubMed, and ISI Web of Science, up to the date of May 22, 2020. Primary outcomes and data regarding fast blood sugar (FBS), lipid profile, and liver enzyme were collected from the available articles, while the studies that did not provide sufficient information on the effects of silver nanoparticles through the course of diabetes mellitus were excluded. Our search yielded 1283 results that included five animal studies in the meta-analysis. The comparison between the plasma insulin level of the diabetic group treated by Ag-NPs with the diabetic control group displayed no significant differences with the P values = 0.299. In addition, significant differences were revealed by comparing the FBS level of the diabetic group treated by Ag-NPs with the diabetic control group (P value < 0.001). According to the present meta-analysis, the application of Ag-NPs in animal models resulted in displaying the anti-diabetic effects, which can be applied in future treatments. Furthermore, a correlation was noticed between these nanoparticles and the reduction of serum FBS among diabetic cases.

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Acknowledgements

We are thankful to the research council of the Mashhad University of Medical Sciences for their support.

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Author notes

  1. Farnaz Torabian and Arash Akhavan Rezayat equally contributed to this manuscript

Authors and Affiliations

  1. Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Farnaz Torabian

  2. Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Arash Akhavan Rezayat, Mohammad Ghasemi Nour & Sara Najafi

  3. Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran

    Arash Akhavan Rezayat

  4. Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Atefeh Ghorbanzadeh

  5. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  6. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Zahra Sabouri

  7. Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Majid Darroudi

  8. Department of Medical Biotechnology and Nanotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Majid Darroudi

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  1. Farnaz Torabian
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Contributions

Farnaz Torabian: Writing original draft, review, and editing. Arash Akhavan Rezayat: Writing original draft, review, and editing. Mohammad Ghasemi Nour: Data acquisition, analysis and interpretation, review, and editing, funding, and resources acquisition. Atefeh Ghorbanzadeh: Data acquisition, analysis and interpretation, review, and editing, funding, and resources acquisition. Sara Najafi: Data acquisition, analysis and interpretation, review, and editing, funding, and resources acquisition. Amirhossein Sahebkar: Data acquisition, analysis and interpretation, review, and editing, funding, and resources acquisition. Zahra Sabouri: Data acquisition, analysis and interpretation, review, and editing, funding, and resources acquisition. Majid Darroudi: Supervision, project administration, review and editing, funding, and resources acquisition.

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Correspondence to Majid Darroudi.

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Torabian, F., Akhavan Rezayat, A., Ghasemi Nour, M. et al. Administration of Silver Nanoparticles in Diabetes Mellitus: A Systematic Review and Meta-analysis on Animal Studies. Biol Trace Elem Res 200, 1699–1709 (2022). https://doi.org/10.1007/s12011-021-02776-1

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