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Effects of Combined Sertraline and Magnesium in Rat Atrium

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Abstract

The objective of this study is to determine the synergistic effects of an antioxidant ion Mg+2, combined with selective serotonin reuptake inhibitor sertraline, in treatment or prevention of major depression and regulation of inotropic effect in the early postoperative period. Adult male 40 Wistar albino rats were randomly divided into 6 groups. Three to 4-mm long atrium strips were placed in organ bath, tension was adjusted to 2 g. Isometric contractions were induced with 10−3 M adrenaline. Group 1 was the control group, cumulative sertraline was given to group 2, cumulative MgSO4 to group 3, combined cumulative sertraline and MgSO4 to group 4, intraperitoneal sertraline injection for 29 days to group 5, and intraperitoneal MgSO4 injection for 14 days to group 6. Changes in weight, tensions, bleeding/clotting time, and biochemical findings were evaluated statistically. Isometric tension relationship between groups 1 and 3 was statistically significant after 4 mmol/L MgSO4 (p < 0.05). A rapid inhibition of contraction was observed in group 4. Inhibition of spontaneous contractions of groups 5 and 6 was found to be statistically significant at close values, p < 0.05. When blood clotting times were compared, a statistically marked decrease was found in group 6, p < 0.05. Compared to control group, there was a significant decrease in blood lipids in group 4. While LDH and CK-MB increased from plasma enzymes in groups 5 and 6, no significant change was observed in NT-proBNP. Combined treatment of high dose MgSO4 with antidepressants for pre or post-operative depression may cause fatal risks. Shortening clotting time may increase the risk of embolism and stroke. In order to reduce the risk of post-operative depression preoperatively, care should be taken when using magnesium combined with antidepressants and more studies are needed to be considered.

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Research Data Policy and Data Availability

The data that support the findings of this study are available from (THIRD PARTY NAME) but restrictionsapply to the availability of these data, which were used under license for the current study, and so are not publicly available. Data are however available from the authors upon reasonable request and with permission of (THIRD PARTY NAME).

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Acknowledgements

This study was supported by Necmettin Erbakan University, Scientific Investigations Projects (SIP Project No: 181318014).

Funding

The study was supported by the Scientific Investigations Projects Coordinatorship of Necmettin Erbakan University (SIPC Project Number: 181318014).

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Authors and Affiliations

  1. Department of Physiology, Necmettin Erbakan University Meram Medical School, Konya, Turkey

    Esra Fidan & Z. Isik Solak Gormus

  2. Department of Biochemistry, Necmettin Erbakan Üniversity Meram Medical School, Konya, Turkey

    İbrahim Kilinc

  3. Department of Medical Education and Informatics, Necmettin Erbakan University Meram Medical School, Konya, Turkey

    Mehmet Sinan İyisoy

  4. Department of Cardiovascular Surgery, Necmettin Erbakan Üniversity Meram Medical School, Konya, Turkey

    Niyazi Gormus

Authors
  1. Esra Fidan
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Contributions

ZISG, EF and NG have made substantial contributions to the conception or design of the study and to the realization of experimental studies and to obtaining data. SI and IK have made the statistical and biochemical analysis and interpretation of the study. They have contributed to the creation of new software used for the study. ZISG and EF have drafted the work and critically revised it for important intellectual content and approved its upcoming version.

Corresponding author

Correspondence to Z. Isik Solak Gormus.

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Ethics Approval

This study protocol was approved by the Experimental Animals Local Ethics Committee of Necmettin Erbakan University Experimental Medicine Application and Research Center (No. 2008-012, on 23.02.2018).

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The authors declare that they have no potential conflicts of interest to disclosure.

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Fidan, E., Gormus, Z.I.S., Kilinc, İ. et al. Effects of Combined Sertraline and Magnesium in Rat Atrium. Biol Trace Elem Res 200, 652–660 (2022). https://doi.org/10.1007/s12011-021-02669-3

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