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Effect of Selenium on Brain Injury in Chickens with Subacute Arsenic Poisoning

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Abstract

The aim of this study was to investigate the effects of different doses of selenium (Se) on oxidative damage and neurotransmitter-related parameters in arsenic (As)-induced broiler brain tissue damage. Two hundred 1-day-old avian broilers were randomly divided into five groups and fed the following diets: control group (As 0.1 mg/kg + Se 0.2 mg/kg), As group (As 3 mg/kg + Se 0.2 mg/kg), low-Se group (As 3 mg/kg + Se 5 mg/kg), medium-Se group (As 3 mg/kg + Se 10 mg/kg), and high-Se group (As 3 mg/kg + Se 15 mg/kg). Glutathione (GSH), glutathione peroxidase (GSH-PX), nitric oxide (NO), nitric oxide synthase (NOS) activity, glutamate (Glu) concentration, glutamine synthetase (GS) activity, acetylcholinesterase (TchE) activity, and the apoptosis rate of brain cells were measured. The results showed that 3 mg/kg dietary As could induce oxidative damage and neurotransmitter disorder of brain tissue, increase the apoptosis rate of brain cells and cause damage to brain tissue, decrease activities of GSH and GSH-PX, decrease the contents of NO, decrease the activities of iNOS and tNOS, increase contents of Glu, and decrease activities of Gs and TchE. Compared with the As group, the Se addition of the low-Se and medium-Se groups protected against As-induced oxidative damage, neurotransmitter disorders, and the apoptosis rate of brain cells, with the addition of 10 mg/kg Se having the best effect. However, 15 mg/kg Se not only did not produce a protective effect against As damage but actually caused similar or severe damage.

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Funding

This manuscript was supported by the Visiting Scholar Program sponsored by the China Scholarship Council (201906915019).

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Authors and Affiliations

  1. College of Veterinary Medicine, Sichuan Agricultural University, Ya’an, 625014, China

    Zhihua Ren, Huidan Deng, Guilin Jia, Youtian Deng, Ling Zhu, Zhicai Zuo & Junliang Deng

  2. Sichuan Province Key Laboratory of Animal Disease & Human Health, Ya’an, 625014, China

    Zhihua Ren, Huidan Deng, Guilin Jia, Youtian Deng, Ling Zhu, Zhicai Zuo & Junliang Deng

  3. Key Laboratory of Environmental Hazard and Human Health of Sichuan Province, Ya’an, 625014, China

    Zhihua Ren, Huidan Deng, Guilin Jia, Youtian Deng, Ling Zhu, Zhicai Zuo & Junliang Deng

  4. Leshan City, Shizhong District of Animal Husbandry Bureau, Leshan, 614000, China

    Qiang Wu & Niao Wen

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  1. Zhihua Ren
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Ren, Z., Deng, H., Wu, Q. et al. Effect of Selenium on Brain Injury in Chickens with Subacute Arsenic Poisoning. Biol Trace Elem Res 200, 330–338 (2022). https://doi.org/10.1007/s12011-021-02630-4

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