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Health Risk Assessment of Metals in Selected Drinks from Abeokuta, Southwestern Nigeria

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Abstract

The present study assessed the human health risk of metals in selected drinks from Abeokuta, southwestern Nigeria. Fifteen different brands of drinks (alcoholic, non-alcoholic, herbal and non-herbal) were purchased from notable markets in Abeokuta between June and August, 2018. A total of sixty drink samples were analysed for metals using atomic absorption spectrophotometry. Data were subjected to descriptive and inferential statistics. Human health risks were assessed for cancer risk (CR) and non-carcinogenic indices of hazard quotient (HQ) and hazard index (HI). Results showed acidic medium for most of the samples ranging from 3.12 ± 0.29 to 6.14 ± 0.17. The highest concentrations of Fe (5.53 ± 2.81 mg/L) and Mn (6.63 ± 8.33 mg/L) were found in Kunnu and Zobo, respectively. The HQ and HI values of Cu in bottled water indicated non-carcinogenic adverse effects, while the CR of Co in bottled water and bitters demonstrated carcinogenic effects. Regular monitoring of metals in drinks from the study area is recommended.

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References

  1. Islam E-U, Yang X-E, He Z-L, Mahmood Q (2007) Assessing potential dietary toxicity of heavy metals in selected vegetables and food crops. J Zhejiang Univ Sci 8:1–13

    Google Scholar 

  2. Izah SC, Aseiba ER, Orutugu LA (2015) Microbial quality of polythene packaged sliced fruits sold in major markets of Yenagoa Metropolis, Nigeria. Point J Bot Microbiol Res 1: 30–36. 3

  3. Arnold JP (2005) Origin and history of beer and brewing: from prehistoric times to the beginning of brewing science and technology: a critical essay. BeerBooks.com, 421p

  4. Iwegbue CMA, Ojelum AL, Bassey FI (2014) A survey of metal profiles in some traditional alcoholic beverages in Nigeria. Food Sci Nutr 2(6):724–733

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Ohimain EI, Tuwon PE, Ayibaebi EA (2012) Traditional fermentation and distillation of raffia palm sap for the production of bioethanol in Bayelsa state, Nigeria. J Technol Innov Ren Ener 1:131–141

    CAS  Google Scholar 

  6. Kigigha LT, Izah SC, Okitah LB (2016) Antibacterial activity of palm wine against Pseudomonas, Bacillus, Staphylococcus, Escherichia, and Proteus spp. Point J Bot Microbiol Res 2:46–52

    Google Scholar 

  7. Ezeagu IE, Fafunso MA (2003) Biochemical constituents of palm wine. Ecol Food Nutr 42:213–222

    Google Scholar 

  8. The Australian Beer and Wine Guide (2016) Hassle-free buzz: alcohol-free beers you should try no. https://beerandwine.guide/beer/alcohol-free-beer/. Accessed: 01/09/2019

  9. Magomya AM, Yebpella GG, Okpaegbe UC (2015) An assessment of metal contaminant levels in selected soft drinks sold in Nigeria. Int J Innov Sci Eng Technol 2(517):522

    Google Scholar 

  10. Adepoju-Bello AA, Oguntibeju OO, Onuegbu MT, Ayoola GAA, Coker HAB (2012) Analysis of selected metallic impurities in soft drinks marketed in Lagos, Nigeria. Afr J Biotechnol 11:4676–4680

    CAS  Google Scholar 

  11. Engwa AG, Ihekwoaba CJ, Ilo US, Unaegbu M, Ayuk L, Osuji AG (2015) Determination of some soft drink constituents and contamination by some heavy metals in Nigeria. Toxicol Rep 2:384–390

    Google Scholar 

  12. Sardinha D, Gueifão S, Coelho I, Nascimento AC, Castanheira I (2014) Perfil de minerais e elementos vestigiais em néctares e sumos de fruta: uma contribuição para o estudo de dieta total. Bolet Epidemiol Inst Nacion de Saúd 11:37–40

    Google Scholar 

  13. IFU (2013) Fruit juice nutrition and health–summary. International Federation of Fruit Juice Producers IFU, Paris (France)

    Google Scholar 

  14. Nilsson M, Duarte IF, Almeida C, Delgadillo I, Goodfellow BJ, Gil AM, Morris GA (2004) High-resolution NMR and diffusion-ordered spectroscopy of port wine. J Agric Food Chem 52:3736–3743

    CAS  PubMed  Google Scholar 

  15. Glanville JM, Brown S, Shamir R, Szajewska H, Eales JF (2015) The scale of the evidence base on the health effects of conventional yogurt consumption: findings of a scoping review. Front Pharmacol 6:1–12

    Google Scholar 

  16. Hassan AA, Karzan AH (2013) Evaluation of trace elements in drinking water of Duhok Province/Kurdistan region of Iraq. IJES 2:47–56

    Google Scholar 

  17. Salvato J, Magardy N, Agardy F (2005) Environmental engineering sanitation, 5th edn. John Wiley and Sons Publication, Hoboken, pp 469–447

  18. WHO (2017) Guidelines for drinking-water quality: fourth edition incorporating the first addendum. Geneva: Licence: CC BY-NC-SA 3.0 IGO

  19. Núñez M, Peña RM, Herrero C, García-Martín S (2000) Analysis of some metals in wine by means of capillary electrophoresis. Application to the differentiation of Ribeira Sacra Spanish red wine. Anal 28:432–437

    Google Scholar 

  20. Banović M, Kırın J, Ćurko N, KovačevićGanıć K (2009) Influence of vintage on cu, Fe, Zn and Pb content in some Croatian red wines. Czech J Food Sci 27:401–403

    Google Scholar 

  21. Garba ZNC, Ugbaje A, Abdullahi K, Garba NN (2013) Chromium, nickel and zinc levels from canned and non-canned beverages in Zaria, Kaduna state, Nigeria. Bayero J Pure Appl Sci 6(1):174–178

    Google Scholar 

  22. Awodele O, Popoola TD, Amadi KC, Coker HAB, Akintonwa A (2013) Traditional medicinal plants in Nigeria—remedies or risks. J Ethnopharmacol 150(2):614–618

    CAS  PubMed  Google Scholar 

  23. Ofori H, Owusu M, Anyebuno G (2013) Heavy metal analysis of fruit juice and soft drinks bought from retail market in Accra, Ghana. J Sci Res Rep 2(1):423–428

    Google Scholar 

  24. AOAC (ed) (2000) Official methods of analysis, 20th edn. AOAC International, Gaithersburg, MD, USA

    Google Scholar 

  25. Taiwo AM, Oyebode AO, Salami FO, Okewole I, Gbogboade AS, Agim C, Davidson N (2018) Carcinogenic and non-carcinogenic evaluations of heavy metals in protein foods from southwestern Nigeria. J Food Composit Anal 73:60–66

    CAS  Google Scholar 

  26. Taiwo AM, Arowolo TA, Adekunle IM, Adetunji MT (2013) Evaluating the environmental impact of poultry farming on stream water quality; a study from Abeokuta Nigeria. Environ Qual Managt 22:77–93

    Google Scholar 

  27. Taiwo AM, Beddows DC, Shi Z, Harrison RM (2014) Mass and number size distributions of particulate matter components: comparison of an industrial site and an urban background site. Sci Tot Environ 475:29–38

    CAS  Google Scholar 

  28. Croghan C, Egeghy PP (2003) Methods of dealing with values below the limit of detection using SAS. Southern SAS User Group, pp:22–24

  29. Carcamo Yañez V, Göpfert J, Otto M, Tumani H, Peter A, Joos T (2017) Development and validation of an ultrasensitive procalcitonin sandwich immunoassay. High-through. 6(4):18

    Google Scholar 

  30. USEPA (2007) United States Environmental Protection Agency, framework for metal risk assessment, EPA 120-R-07-001, Washington DC, 2007

  31. WHO (2015) Country Statistics, Nigeria.www.who.int/country/nga/en. Accessed: 10/07/16

  32. Taiwo AM, Awomeso JA (2017) Assessment of trace metal concentration and health risk of artisanal gold mining activities in Ijeshaland, Osun state Nigeria—part 1. J Geochem Explor 177:1–10

    CAS  Google Scholar 

  33. USEPA (United States Environmental Protection Agency) (2001) Risk assessment guidance for superfund: process for conducting probabilistic risk assessment (Part A); EPA 540-R-02-002; USEPA: Washington, DC, USA, (3). https://www.epa.gov/risk/risk-assessment-guidance-superfund-rags-volume-iii-part .

  34. Akande IS, Adewoyin OA, Njoku UF, Awosika SO (2012) Biochemical evaluation of some locally prepared herbal remedies (Agbo) currently on high demand in Lagos Metropolis, Nigeria. J Drug Met Toxicol 3:1–5. https://doi.org/10.4172/2157-7609.1000118

    Article  Google Scholar 

  35. Lewis JL (2019) Acidosis. MSD and the MSD manuals. https://www.msdmanuals.com/ home/hormonal-and-metabolic-disorders/acid-base-balance/acidosis. Accessed: 02/09/2019

  36. WHO (1993a) Guidelines for drinking water quality, 2nd edn. World Health Organization, Geneva

    Google Scholar 

  37. Shova TC (2014) Evaluation of physico-chemical characteristics of drinking water supply in Kathmandu, Nepal. Res J Chem Sci 4(4):33–36

    CAS  Google Scholar 

  38. Jahagirdar S, Patki VK, Thavare M, Patil MS, Rangre S (2015) Comparative study of water quality parameters of different brands of soft drinks. IOSR J Mech Civ Eng. 142-149. E-ISSN : 2278-1684, p-ISSN : 2320-334X

  39. London L, Dalvie MA, Nowicki A, Cairncross E (2005) Approaches for regulating water in South Africa for the presence of pesticides. Water Sanitat 31(1):53–60

    CAS  Google Scholar 

  40. Abdel-Rahman GN, Ahmed BMM, Sabry BA, Ali SMS (2019) Heavy metals content in some non-alcoholic beverages (carbonated drinks, flavoured yoghurt drinks, and juice drinks) of the Egyptian markets. Toxicol Rep 6:210–214. https://doi.org/10.1016/j.toxrep.2019.02.010

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Roberts II, Orisakwe OE (2011) Evaluation of potential dietary toxicity of heavy metals in some common Nigerian beverages: a look at antimony, tin and mercury. Q Sci Connect 2(1):1–10

    Google Scholar 

  42. Moreira S, Vives AE, Zucchi OL, Jesus EF, Filho VF (2006) Analysis of beers from Brazil with synchrotron radiation total reflection X-ray fluorescence. J Radioanal Nucl Chem 270:167–171

    CAS  Google Scholar 

  43. WHO (2007) WHO guidelines for assessing quality of herbal medicines with reference to contaminants and residues. https://apps.who.int/iris/bitstream/handle/10665/43510/9789241594448_eng.pdf?Sequenc e=1&is Allowed=y

  44. Wongsasuluk P, Chotpantarat S, Siriwong W, Robson M (2013) Heavy metal contamination and human health risk assessment in drinking water from shallow groundwater wells in an agricultural area in Ubon Ratchathani province, Thailand. Environ Geochem Health 36:169–182

    PubMed  Google Scholar 

  45. Mena CM, Cabrera C, Lorenzo ML, Lopez MC (1997) Determination of lead contamination in Spanish wines and other alcoholic beverages by flow injection atomic absorption spectrometry. J Agric Food Chem 45:1812–1815

    CAS  Google Scholar 

  46. Khan I, Mehmood Z, Khan M, Fatima T (2016) Analysis and detection of heavy metals present in fruit juices of Lahore. Int J Engineering Sci 6:3536–3539

    Google Scholar 

  47. Taiwo AM, Oyeleye OF, Majekodunmi BJ, Anuobi VE, Afolabi SA, Idowu OE, Ojekunle ZO, Taiwo OT (2019) Evaluating the health risk of metals (Zn, Cr, cd, Ni, Pb) in staple foods from Lagos and Ogun states, southwestern Nigeria. Environ Monit Assess 191(3):1–11

    CAS  Google Scholar 

  48. Hague TA, Petroczi PL, Andrews R, Barker J, Naughton DP (2008) Determination of metal ion contents of beverages and estimation of target hazard quotients: a comparative study. Chem Cent J 2(1):1–9

    Google Scholar 

  49. Oberley MJ, Yang DT (2013) Laboratory testing for cobalamin deficiency in megaloblastic anemia. Am J Hematol 88(6):522–526

    CAS  PubMed  Google Scholar 

  50. Llorent-Martínez EJ, de Córdova MLF, Ruiz-Medina A, Ortega-Barrales P (2012) Analysis of 20 trace and minor elements in soy and dairy yogurts by ICPMS. Microchem J 102:23–27

    Google Scholar 

  51. Samali A, Mohammed MI, Ibrahim MB (2017) Analysis of heavy metals concentration in Kano herbal preparations for major disease conditions. ChemSearch J 8(2):22–28

    Google Scholar 

  52. NAFDAC (2019) Fruit juice and nectar regulations. National Agency for Food and Drug Administration and control https://www.nafdac.gov.ng/wp-content/uploads/Files/Resources/Regulations/All_Regulations /fruit-juice-and-nectar-Regulations-2019.Pdf. Accessed: 30/11/2019

  53. Kumar A, Rai AK, Basu S, Dash D, Singh JS (2008) Cord blood and breast milk iron status in maternal anemia. Pediatr 121:673–677

    Google Scholar 

  54. Atooh CA, Sowley ENK (2018) Effect of heavy metals in brewery water sources and Pito brewed from them in tamale Metropolis and Tolon District, Ghana. J Sci Res Report 19(5):1–10

    Google Scholar 

  55. Salako SG, Adekoyeni OO, Adegbite AA, Hammed TB (2016) Determination of metals content of alcohol and non-alcoholic canned drinks consumed at Idiroko border town Ogun state Nigeria. Brewery J Appl Sci Technol 12:1–8

    Google Scholar 

  56. Lara R, Cerutti S, Salonia JA, Olsina RA, Martinez LD (2005) Trace element determination of Argentine wines using ETAAS and USN-ICP-OES. Food Chem Toxicol 43:293–297

    CAS  PubMed  Google Scholar 

  57. Santos CEID, Silva LRMD, Boufleur LA, Debastiani R, Stefenon CA, Amaral L, Yoneama ML, Dias JF (2010) Elemental characterization of cabernet sauvignon wines using particle-induced X-ray emission. Food Chem 121:244–250

    Google Scholar 

  58. Rodríguez GG, Moreno DH, Soler F, López MP (2011) Characterization of “Ribera del Guadiana” and “Méntrida” Spanish red wines by chemometric techniques based on their mineral contents. J Food Nutr Res 50:41–49

    Google Scholar 

  59. Okedi C, Oni OO (1997) Basic water treatment operation. Edited by outreach department, published by National Water Resources Institute, Kaduna, pp. 1-90

  60. Iweala EEJ, Olugbuyiro JAO, Durodola BM (2014) Fubara-Manuel, D.R. and Okoli, a.O. metal contamination of foods and drinks consumed in Ota, Nigeria. Res J Environ Toxicol 8:92–97

    Google Scholar 

  61. Onianwa PC, Adeyemo AO, Idowu OE, Ogabıela EE (2001) Copper and zinc contents of Nigerian foods and estimates of the adult dietary intakes. Food Chem 72:89–95

    CAS  Google Scholar 

  62. Kyeremeh K, Agbemafo FW, Appiah-Opong R (2013) Quantitative analysis of chemical contaminants in Ghanaian herbal alcoholic bitters. Inter J Chem Appl 5(2):153–167

    Google Scholar 

  63. Briggs DE, Boulton AC, Brookes AP, Stevens R (2004) Malts, adjunct and supplementary enzymes, brewing science and practice. Woodhead, Cambridge, UK, pp 30–34

    Google Scholar 

  64. Kemasuode T, Okoye BC, Gav BL (2016) Metal concentration in three popular local drinks consumed in Benue state, Nigeria. Inter J Sci Res 5(3):647–651

    Google Scholar 

  65. ATSDR (2015) Public health statement for manganese. Agency for Toxic Substances and Disease Registry. http://www.atsdr.cdc.gov/phs/phs.asp?id=100&tid=23(Accessed:12/07/2016)

  66. WHO (1993b) Evaluation of certain food additives and contaminants. In: Forty-First Report of the Joint FAO/WHO Expert Committee on Food Additives., WHO, Geneva, Switzerland. (WHO Technical Series, 837)

  67. FAO/WHO (2011) Codex Alimentarius Commission. Working document for information and use in discussions related to contaminants and toxins in the GSCTFF (Prepared by Japan and the Netherlands). Joint FAO/WHO food standards programme codex committee on contaminants in foods. The Hague, The Netherlands, 21–25 March 2011. CF/5INF/1. http://www.fao.org/tempref/codex /Meetings/CCCF/CCCF5 /cf05_INF.pdf. Accessed:15/01/2019

  68. Aisen P, Enns C, Wessling-Resnick M (2001) Chemistry and biology of eukaryotic iron metabolism. Int J Biochem Cell Biol 33(10):940–959

    CAS  PubMed  Google Scholar 

  69. Eticha T, Hymete A (2014) Health risk assessment of heavy metals in locally produced beer to the population in Ethiopia. Journal of Bioanalytical Biomedicine 6:065–068

    CAS  Google Scholar 

  70. ATSDR (2004) Minimum risk levels. Agency for toxic substances and disease registry. January 2004. http://www.atsdr.cdc.gov/mrls.html. Accessed: 22/09/2019

  71. USEPA PPRTV (2006) Provisional Peer-Reviewed Toxicity Values for Iron and Compounds. https://cfpub.epa.gov/ncea/risk/recordisplay.cfm?deid=338968. Accessed: 09/05/2019

  72. National Research Council (2000). Health effects of excess copper. In: Copper in Drinking Water. National Academies Press (US)

  73. Salama AK, Radwan RM (2005) Heavy metals (cd, Pb) and trace elements (cu, Zn) contents in some foodstuffs from the Egyptian market. Emir J Agric Sci 17(1):34–42

    Google Scholar 

  74. Saravu K, Jose J, Bhat MN, Jimmy B, Shastry B (2007) Acute ingestion of copper sulphate: a review on its clinical manifestations and management. Ind J Crit Care Med 11(2):74–80

    Google Scholar 

  75. Ayantobo OO, Awomeso JA, Oluwasanya GO, Bada BS, Taiwo AM (2014) Non-cancer human health risk assessment from exposure to heavy metals in surface and groundwater in IgunIjesha, Southwest Nigeria. Am J Environ Sci 10(3):301–311

    CAS  Google Scholar 

  76. Ayedun H, Gbadebo AM, Idowu OA, Arowolo TA (2015) Toxic elements in groundwater of Lagos and Ogun states, southwest, Nigeria and their human health risk assessment. Environ Monit Assess 187(6):1–17

    CAS  Google Scholar 

  77. Li J, Wang Y, Yang H, Yu P, Tang Y (2018) Five heavy metals accumulation and health risk in a traditional Chinese medicine cortex Moutan collected from different sites in China. Hum Ecol Risk Assess: An Inter J 24(8):2288–2298

    CAS  Google Scholar 

  78. Towle KM, Garnick LC, Monnot AD (2017) A human health risk assessment of lead (Pb) ingestion among adult wine consumers. Int J Food Contam 4(1):7

    Google Scholar 

  79. Bamuwamye M, Ogwok P, Tumuhairwe V, Eragu R, Nakisozi H, Ogwang PE (2017) Human health risk assessment of heavy metals in Kampala (Uganda) drinking water. J Food Res 6(4):6–16

    CAS  Google Scholar 

  80. Simonsen LO, Harbak H, Bennekou P (2012) Cobalt metabolism and toxicology—a brief update. Sci Tot Environ 432:210–215

    CAS  Google Scholar 

  81. Otim O, Juma T, Otunnu O (2019) Assessing the health risks of consuming ‘sachet’ alcohol in Acholi, Uganda. PLoS One 14(2):e0212938

    CAS  PubMed  PubMed Central  Google Scholar 

  82. WHO (2014) Alcohol consumption: level and patterns. https://www.who.int/substance_abuse/publications/global_alcohol_report/profiles/nga.pdf?ua=1. Accessed: 09/05/2019

  83. Jedy-Agba E, Curado MP, Ogunbiyi O, Oga E, Fabowale T, Igbinoba F, Adebamowo CA (2012) Cancer incidence in Nigeria: a report from population-based cancer registries. Cancer Epidemiol 36(5):271–278

    Google Scholar 

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Acknowledgements

The authors are grateful to the assistance provided by the Technologists of the Department of Environmental Management and Toxicology, during the laboratory analysis.

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  1. Department of Environmental Management and Toxicology, Federal University of Agriculture, PMB, Abeokuta, 2240, Nigeria

    Adewale Matthew Taiwo, Cynthia Odion Aigbodion & Oluwaseyi Zacchaeus Ojekunle

  2. Department of Chemistry, Federal University of Agriculture, PMB, Abeokuta, 2240, Nigeria

    Temilade Fola Akinhanmi

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  1. Adewale Matthew Taiwo
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Correspondence to Adewale Matthew Taiwo.

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Taiwo, A.M., Aigbodion, C.O., Ojekunle, O.Z. et al. Health Risk Assessment of Metals in Selected Drinks from Abeokuta, Southwestern Nigeria. Biol Trace Elem Res 197, 694–707 (2020). https://doi.org/10.1007/s12011-020-02029-7

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