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Effect of Titanium Dioxide Nanoparticles on the Resistance of Silkworm to Cytoplasmic Polyhedrosis Virus in Bombyx mori

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Abstract

Bombyx mori cytoplasmic polyhedrosis virus (BmCPV) is a serious disease harmful to silk industry, which is one of the major sources of financial support for farmers in many developing countries. So far, there is still no good way to prevent or treat this disease. In this study, titanium dioxide nanoparticles (TiO2 NPs) were used to pretreat silkworm larvae, and good results were achieved in improving silkworm immunity and alleviating the damage of cytoplasmic polyhedrosis virus. The results showed that nano-titanium dioxide pretreatment could inhibit the proliferation of BmCPV in the midgut of silkworm, activate JAK/STAT and PI3K-AKT immune signaling pathways, and upregulate the expression of key immune genes, so as to improve the immunity of silkworm and enhance the resistance of silkworm to BmCPV.

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Funding

This work was supported by the Foundation of Post Scientist in National Sericultural System (Grant No. CARS-22-ZJ0101), the Natural Science Foundation of Jiangsu Province (Grant No. BK20181228), the Key Research & Development program of Zhenjiang (Grant No. NY2018021), and the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (Grant No. 17KJB230001).

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Author notes

  1. Guodong Zhao and Xiao Zhang contributed equally to this work.

Authors and Affiliations

  1. School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang, 212018, Jiangsu, China

    Guodong Zhao, Xiao Zhang, Jialu Cheng, Xin Huang, Heying Qian, Gang Li & Anying Xu

  2. Sericultural Research Institute, Chinese Academy of Agricultural Sciences, Zhenjiang, 212018, Jiangsu, China

    Guodong Zhao, Heying Qian, Gang Li & Anying Xu

  3. College of Biotechnology, Jiangsu University of Science and Technology, No. 2 Mengxi Road, Zhenjiang, 212018, People’s Republic of China

    Anying Xu

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  1. Guodong Zhao
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  2. Xiao Zhang
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  3. Jialu Cheng
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  4. Xin Huang
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  5. Heying Qian
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  6. Gang Li
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Correspondence to Anying Xu.

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Zhao, G., Zhang, X., Cheng, J. et al. Effect of Titanium Dioxide Nanoparticles on the Resistance of Silkworm to Cytoplasmic Polyhedrosis Virus in Bombyx mori. Biol Trace Elem Res 196, 290–296 (2020). https://doi.org/10.1007/s12011-019-01901-5

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