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Selenium-Rich-Yeast Protects Against Aluminum-Induced Activating Nuclear Xenobiotic Receptors and Triggering Inflammation and Cytochromes P450 Systems in Mice Heart

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Abstract

Aluminum (Al) poisoning is linked to the development of cardiovascular diseases, and dietary supplementation with selenium-rich-yeast (SeY) has been shown to prevent inflammatory conditions. We evaluated the preventive effect of SeY on Al-induced cardiotoxicity, and the possible underlying mechanisms. Mice were treated with SeY (0.1 mg/kg) and/or Al (10 mg/kg) by oral gavage for 4 weeks. Histopathological damage was observed in the heart of Al-treated mice, in addition to the transcriptional up/downregulation of nuclear xenobiotic receptors (NXRs), inflammatory cytokines and 15 CYP450s genes. SeY significantly inhibited these Al-induced histopathological and molecular changes, and restored these indicators to the control levels. These results suggest that SeY exerts a cardio-protective effect against Al-induced toxicity through the NXR system, inflammatory cytokines, and CYP450s genes.

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Funding

This work was supported by Foshan University research star-up project (099/CGZ07276), Foshan University lingnan Scholars Launch Project (099/CGZ07084), and Key Laboratory of preventive veterinary medicine in Guangdong Provincial Department of Education (2014KTSPT037).

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  1. College of Life Science and Engineering, Foshan University, Foshan, Guangdong, People’s Republic of China

    Changyu Cao, Xiaowen Li, Qiang Fu, Kai Wang & Xinran Li

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  1. Changyu Cao
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  2. Xiaowen Li
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  4. Kai Wang
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Correspondence to Xinran Li.

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All animal studies reported here were approved by the Institutional Animal Care and Use Committee of the Foshan University.

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Cao, C., Li, X., Fu, Q. et al. Selenium-Rich-Yeast Protects Against Aluminum-Induced Activating Nuclear Xenobiotic Receptors and Triggering Inflammation and Cytochromes P450 Systems in Mice Heart. Biol Trace Elem Res 194, 244–250 (2020). https://doi.org/10.1007/s12011-019-01763-x

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