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The influence of different aluminium compounds on the hippocampal morphofunctional state and conditioning in mice

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Abstract

Notwithstanding that there are many researches pursuing in aim to define a neurotoxic behavior of various compounds of aluminium, its role as a potential neurotoxin is debatable to this day. The present study was aimed at comparison of neurotoxic action of aluminium in the forms of chloride and citrate, administered orally in a dose of Al3+=0.1 mg/kg of body weight per day. The results of double T-maze tests that were used for detection of cognitive impairment, and results of histological and micromorphometric examination of hippocampal CA1 neurons are presented. At research findings, we revealed violations of memory and learning processes and also irreversible morphological changes of hippocampal CA1 neurons in aluminium citrate intoxicated mice, that were expressed more than in aluminium chloride intoxicated mice. Furthermore, we caught neuronal atrophy in hippocampal CA1 area of both mice groups, and it was more pronounced in aluminium citrate intoxicated group. Basing of conducted study, it could be concluded that different aluminium compounds in a real taking dose have a neurotoxic action that influence both morphofunctional integrality of hippocampus and cognitive function of CNS, more expressing on exposure to aluminium citrate.

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Authors and Affiliations

  1. Researching Laboratory of Experimental Biology and Biotechnology, Moscow State Regional University, 10A Radio st., Moscow, Russian Federation

    Iaroslavna A. Kuznetsova, David A. Areshidze & Maria A. Kozlova

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  1. Iaroslavna A. Kuznetsova
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  3. Maria A. Kozlova
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Correspondence to Iaroslavna A. Kuznetsova.

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Kuznetsova, I.A., Areshidze, D.A. & Kozlova, M.A. The influence of different aluminium compounds on the hippocampal morphofunctional state and conditioning in mice. Toxicol. Environ. Health Sci. 9, 215–221 (2017). https://doi.org/10.1007/s13530-017-0323-3

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  • DOI: https://doi.org/10.1007/s13530-017-0323-3

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