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Antioxidant and Cytoprotective Activity of Oxydiacetate Complexes of Cobalt(II) and Nickel(II) with 1,10-Phenantroline and 2,2′-Bipyridine

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Abstract

The antioxidant properties of oxydiacetate complexes of cobalt(II) and nickel(II) with 1,10-phenantroline and 2,2′-bipyridine have been investigated towards the superoxide radical using the nitro blue tetrazolium chloride (NBT) test and the cyclic voltammetry (CV). Moreover, the biological activity of the complexes under study has been investigated in the Human Dermal Fibroblasts adult (HDFa) cell line. In the first step, the cytotoxic and the antiproliferative activities of the complexes were examined. Subsequently, the cytoprotective properties of the complexes have been investigated in an oxidative stress conditions induced by H2O2.

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Funding

This work was supported by National Science Centre, Poland, under Grant number 2015/19/N/ST5/00276.

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Authors and Affiliations

  1. Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308, Gdańsk, Poland

    Agnieszka Piotrowska-Kirschling, Joanna Drzeżdżon, Dariusz Wyrzykowski, Lech Chmurzyński & Dagmara Jacewicz

  2. Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308, Gdańsk, Poland

    Anna Kloska

Authors
  1. Agnieszka Piotrowska-Kirschling
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  2. Joanna Drzeżdżon
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  3. Anna Kloska
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  4. Dariusz Wyrzykowski
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  5. Lech Chmurzyński
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  6. Dagmara Jacewicz
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Correspondence to Dagmara Jacewicz.

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Piotrowska-Kirschling, A., Drzeżdżon, J., Kloska, A. et al. Antioxidant and Cytoprotective Activity of Oxydiacetate Complexes of Cobalt(II) and Nickel(II) with 1,10-Phenantroline and 2,2′-Bipyridine. Biol Trace Elem Res 185, 244–251 (2018). https://doi.org/10.1007/s12011-018-1243-z

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  • DOI: https://doi.org/10.1007/s12011-018-1243-z

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