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Blood Selenium Concentration and Blood Cystatin C Concentration in a Randomly Selected Population of Healthy Children Environmentally Exposed to Lead and Cadmium

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Abstract

This study aimed at evaluation of a relationship between blood selenium concentration (Se-B) and blood cystatin C concentration (CST) in a randomly selected population of healthy children, environmentally exposed to lead and cadmium. The studies were conducted on 172 randomly selected children (7.98 ± 0.97 years). Among participants, the subgroups were distinguished, manifesting marginally low blood selenium concentration (Se-B 40–59 μg/l), suboptimal blood selenium concentration (Se-B: 60–79 μg/l) or optimal blood selenium concentration (Se-B ≥ 80 μg/l). At the subsequent stage, analogous subgroups of participants were selected separately in groups of children with BMI below median value (BMI <16.48 kg/m2) and in children with BMI ≥ median value (BMI ≥16.48 kg/m2). In all participants, values of Se-B and CST were estimated. In the entire group of examined children no significant differences in mean CST values were detected between groups distinguished on the base of normative Se-B values. Among children with BMI below 16.48 kg/m2, children with marginally low Se-B manifested significantly higher mean CST values, as compared to children with optimum Se-B (0.95 ± 0.07 vs. 0.82 ± 0.15 mg/l, p < 0.05). In summary, in a randomly selected population of healthy children no relationships could be detected between blood selenium concentration and blood cystatin C concentration. On the other hand, in children with low body mass index, a negative non-linear relationship was present between blood selenium concentration and blood cystatin C concentration.

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References

  1. Burk RF, Hill KE (2009) Selenoprotein P-expression, functions, and roles in mammals. Biochim Biophys Acta 1790:1441–1447

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Stone CA, Kawai K, Kupka R, Fawzi WW (2010) Role of selenium in HIV infection. Nutr Rev 68:671–681

    Article  PubMed  PubMed Central  Google Scholar 

  3. Boitani C, Puglisi R (2008) Selenium, a key element in spermatogenesis and male fertility. Adv Exp Med Biol 636:65–73

    Article  CAS  PubMed  Google Scholar 

  4. Black RE (2001) Micronutrients in pregnancy. Br J Nutr 85:S193–S197

    Article  CAS  PubMed  Google Scholar 

  5. Micke O, Schomburg L, Buentzel J, Kisters K, Muecke R (2009) Selenium in oncology: from chemistry to clinics. Molecules 14:3975–3988

    Article  CAS  PubMed  Google Scholar 

  6. Navas-Acien A, Bleys J, Guallar E (2008) Selenium intake and cardiovascular risk: what is new? Curr Opin Lipidol 19:43–49

    Article  CAS  PubMed  Google Scholar 

  7. Köhrle J (2013) Selenium and the thyroid. Curr Opin Endocrinol Diabetes Obes 20:441–448

    Article  PubMed  Google Scholar 

  8. Lubos E, Sinning CR, Schnabel RB, Wild PS, Zeller T, Rupprecht HJ, Bickel C, Lackner KJ, Peetz D, Loscalzo J, Münzel T, Blankenberg S (2010) Serum selenium and prognosis in cardiovascular disease: results from the AtheroGene study. Atherosclerosis 209:271–277

    Article  CAS  PubMed  Google Scholar 

  9. Onopiuk A, Tokarzewicz A, Gorodkiewicz E (2015) Cystatin C: a kidney function biomarker. Adv Clin Chem 68:57–69

    Article  PubMed  Google Scholar 

  10. Odutayo A, Cherney D (2012) Cystatin C and acute changes in glomerular filtration rate. Clin Nephrol 78:64–75

    Article  CAS  PubMed  Google Scholar 

  11. Peralta CA, Whooley MA, Ix JH, Shlipak MG (2006) Kidney function and systolic blood pressure new insights from cystatin C: data from the Heart and Soul Study. Am J Hypertens 19:939–946

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Shlipak MG, Katz R, Sarnak MJ, Fried LF, Newman AB, Stehman-Breen C, Seliger SL, Kestenbaum B, Psaty B, Tracy RP, Siscovick DS (2006) Cystatin C and prognosis for cardiovascular and kidney outcomes in elderly persons without chronic kidney disease. Ann Intern Med 145:237–246

    Article  CAS  PubMed  Google Scholar 

  13. Shlipak MG, Wassel Fyr CL, Chertow GM, Harris TB, Kritchevsky SB, Tylavsky FA, Satterfield S, Cummings SR, Newman AB, Fried LF (2006) Cystatin C and mortality risk in the elderly: the health, aging, and body composition study. J Am Soc Nephrol 17:254–261

    Article  CAS  PubMed  Google Scholar 

  14. Luo J, Wang LP, Hu HF, Zhang L, Li YL, Ai LM, Mu HY (2015) Cystatin C and cardiovascular or all-cause mortality risk in the general population: a meta-analysis. Clin Chim Acta 450:39–45

    Article  CAS  PubMed  Google Scholar 

  15. Angelidis C, Deftereos S, Giannopoulos G, Anatoliotakis N, Bouras G, Hatzis G, Panagopoulou V, Pyrgakis V, Cleman MW (2013) Cystatin C: an emerging biomarker in cardiovascular disease. Curr Top Med Chem 13:164–179

    Article  CAS  PubMed  Google Scholar 

  16. Weaver VM, Kim NS, Lee BK, Parsons PJ, Spector J, Fadrowski J, Jaar BG, Steuerwald AJ, Todd AC, Simon D, Schwartz BS (2011) Differences in urine cadmium associations with kidney outcomes based on serum creatinine and cystatin C. Environ Res 111:1236–1242

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Poręba R, Gać P, Poręba M, Antonowicz-Juchniewicz J, Andrzejak R (2011) Relation between occupational exposure to lead, cadmium, arsenic and concentration of cystatin C. Toxicology 283:88–95

    Article  PubMed  Google Scholar 

  18. Skröder H, Hawkesworth S, Kippler M, El Arifeen S, Wagatsuma Y, Moore SE, Vahter M (2015) Kidney function and blood pressure in preschool-aged children exposed to cadmium and arsenic-potential alleviation by selenium. Environ Res 140:205–213

    Article  PubMed  Google Scholar 

  19. Agha FE, Youness ER, Selim MM, Ahmed HH (2014) Nephroprotective potential of selenium and taurine against mercuric chloride induced nephropathy in rats. Ren Fail 36:704–716

    Article  CAS  PubMed  Google Scholar 

  20. Ben Amara I, Karray A, Hakim A, Ben Ali Y, Troudi A, Soudani N, Boudawara T, Zeghal KM, Zeghal N (2013) Dimethoate induces kidney dysfunction, disrupts membrane-bound ATPases and confers cytotoxicity through DNA damage. Protective effects of vitamin E and selenium. Biol Trace Elem Res 156:230–242

    Article  CAS  PubMed  Google Scholar 

  21. Gać P, Pawlas N, Poręba R, Poręba M, Markiewicz-Górka I, Januszewska L, Olszowy Z, Pawlas K (2015) Interaction between blood selenium concentration and a levels of oxidative stress and antioxidative capacity in healthy children. Environ Toxicol Pharmacol 39:137–144

    Article  PubMed  Google Scholar 

  22. Pawlas N, Dobrakowski M, Kasperczyk A, Kozłowska A, Mikołajczyk A, Kasperczyk S (2016) The level of selenium and oxidative stress in workers chronically exposed to lead. Biol Trace Elem Res 170(1):1–8

    Article  CAS  PubMed  Google Scholar 

  23. Stępniewska J, Gołembiewska E, Dołęgowska B, Domański M, Ciechanowski K (2015) Oxidative stress and antioxidative enzyme activities in chronic kidney disease and different types of renal replacement therapy. Curr Protein Pept Sci 16:243–248

    Article  PubMed  Google Scholar 

  24. Rubattu S, Pagliaro B, Pierelli G, Santolamazza C, Castro SD, Mennuni S, Volpe M (2014) Pathogenesis of target organ damage in hypertension: role of mitochondrial oxidative stress. Int J Mol Sci 16(1):823–839

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgments

This work was supported by the European Union through its Sixth Framework Programme for RTD (contract no FOOD-CT-2006-016253). It reflects only the author’s views. The Community is not liable for any use that may be made of the information contained therein.

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Authors and Affiliations

  1. Department of Hygiene, Wroclaw Medical University, Mikulicza-Radeckiego 7, 50-368, Wrocław, Poland

    Paweł Gać & Krystyna Pawlas

  2. Institute of Occupational Medicine and Environmental Health in Sosnowiec, Kościelna 13, 41-200, Sosnowiec, Poland

    Natalia Pawlas, Paweł Wylężek & Krystyna Pawlas

  3. Department of Internal Medicine, Occupational Diseases and Hypertension, Wroclaw Medical University, Borowska 213, 50-556, Wrocław, Poland

    Rafał Poręba

  4. Department of Pathophysiology, Wroclaw Medical University, Marcinkowskiego 1, 50-368, Wrocław, Poland

    Małgorzata Poręba

Authors
  1. Paweł Gać
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  2. Natalia Pawlas
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  3. Paweł Wylężek
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  4. Rafał Poręba
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  5. Małgorzata Poręba
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  6. Krystyna Pawlas
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Correspondence to Paweł Gać.

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Funding

This study was funded by the European Union through its Sixth Framework Programme for RTD (contract no FOOD-CT-2006-016,253).

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed Consent

Written informed consent was obtained from one parent or a caregiver and an oral consent from the child.

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Gać, P., Pawlas, N., Wylężek, P. et al. Blood Selenium Concentration and Blood Cystatin C Concentration in a Randomly Selected Population of Healthy Children Environmentally Exposed to Lead and Cadmium. Biol Trace Elem Res 175, 33–41 (2017). https://doi.org/10.1007/s12011-016-0758-4

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  • DOI: https://doi.org/10.1007/s12011-016-0758-4

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