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Integrative Multivariate Logistic Regression Analysis of Risk Factors for Kashin-Beck disease

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Abstract

To determine the current evidence on risk factors for Kashin-Beck disease (KBD) using an integrative meta-analysis. We searched five English and three Chinese databases from inception to September 2015, to identify case-control studies that examined risk factors for KBD using multivariate logistic analysis. DerSimonian and Laird effective models are applied in processing data using pooled odds ratios (ORs) and 95 % confidence intervals (CI). Seven studies were identified with 3087 cases and 6402 controls. The main risk factors found to be significantly associated with the onset of KBD were age (OR 1.19, 95 % CI 1.10–1.28), parents prevalence (OR 5.16, 2.51–7.80), family hygiene (OR 1.68, 1.42–1.93), food source (OR 3.29, 2.38–4.19), wheat (OR 1.12, 1.08–1.16), wheat germ necrosis rate (OR 6.03, 1.87–12.92), total volatile basic nitrogen (OR 6.85, 1.01–28.67), low selenium in hair (OR 2.29, 1.08–3.50) were found to be significant risks factors. The pooled ORs (95 % CI) of protein intake and rice were 0.79 (0.66–0.93) and 0.90 (0.86–0.95), respectively, indicating that the two factors may be protective for KBD. We found that the combination of low protein intake, polluted grain, and selenium deficiency may contribute to be onset of KBD together.

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Acknowledgments

We thank the National Natural Scientific Foundation of China (81472924) and the Fundamental Research Funds for the Central Universities.

Financial Support

This study received financial support from the National Natural Scientific Foundation of China (81472924) and the Fundamental Research Funds for the Central Universities in 2015.

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Authors and Affiliations

  1. Institute of Endemic Diseases, School of Public Health of Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xian Jiaotong University, No. 76 Yan Ta West Road, Xi’an, Shaanxi, 710061, People’s Republic of China

    Fang-fang Yu, Huan Liu & Xiong Guo

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  1. Fang-fang Yu
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  2. Huan Liu
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  3. Xiong Guo
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Correspondence to Xiong Guo.

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The authors declare that they have no conflict of interest.

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Fang-fang Yu and Huan Liu contributed equally to this work and should be considered co-first authors.

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Yu, Ff., Liu, H. & Guo, X. Integrative Multivariate Logistic Regression Analysis of Risk Factors for Kashin-Beck disease. Biol Trace Elem Res 174, 274–279 (2016). https://doi.org/10.1007/s12011-016-0712-5

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  • DOI: https://doi.org/10.1007/s12011-016-0712-5

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