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Effect of Selenium Supplementation on Glycemic Control and Lipid Profiles in Patients with Diabetic Nephropathy

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28 February 2020 The Editors-in-Chief are currently investigating this article [Bahmani, F., Kia, M., Soleimani, A. et al. Effect of Selenium Supplementation on Glycemic Control and Lipid Profiles in Patients with Diabetic Nephropathy. Biol Trace Elem Res 172, 282–289 (2016). https://doi.org/10.1007/s12011-015-0600-4] as concerns have been raised about integrity of the clinical trial reported here. There is also an ongoing investigation by the Iranian National Committee for Ethics in Biomedical Researches. Further editorial action will be taken as appropriate once the investigation into the concerns is complete and all parties have been given an opportunity to respond in full.

Abstract

To our knowledge, data on the effects of selenium supplementation on glycemic control and lipid concentrations in patients with diabetic nephropathy (DN) are scarce. The current study was done to determine the effects of selenium supplementation on glycemic control and lipid concentrations in patients with DN. This was a randomized double-blind placebo-controlled clinical trial in which 60 patients with DN were randomly allocated into two groups to receive either 200 μg of selenium supplements (n = 30) or placebo (n = 30) daily for 12 weeks. Blood sampling was performed for the quantification of glycemic indicators and lipid profiles at the onset of the study and after 12 weeks of intervention. Selenium supplementation for 12 weeks resulted in a significant decrease in serum insulin levels (P = 0.01), homeostasis model of assessment-estimated insulin resistance (HOMA-IR) (P = 0.02), homeostasis model of assessment-estimated B cell function (HOMA-B) (P = 0.009) and a significant rise in plasma glutathione peroxidase (GPx) (P = 0.001) compared with the placebo. Taking selenium supplements had no significant effects on fasting plasma glucose (FPG), quantitative insulin sensitivity check index (QUICKI) and lipid profiles compared with the placebo. Overall, our study demonstrated that selenium supplementation for 12 weeks among patients with DN had beneficial effects on plasma GPx, serum insulin levels, HOMA-IR, and HOMA-B, while it did not affect FPG, QUICKI, and lipid profiles.

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  • 28 February 2020

    The Editors-in-Chief are currently investigating this article [Bahmani, F., Kia, M., Soleimani, A. et al. Effect of Selenium Supplementation on Glycemic Control and Lipid Profiles in Patients with Diabetic Nephropathy. Biol Trace Elem Res 172, 282–289 (2016). https://doi.org/10.1007/s12011-015-0600-4] as concerns have been raised about integrity of the clinical trial reported here. There is also an ongoing investigation by the Iranian National Committee for Ethics in Biomedical Researches. Further editorial action will be taken as appropriate once the investigation into the concerns is complete and all parties have been given an opportunity to respond in full.

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Acknowledgments

The present study was supported by a grant from the Vice-chancellor for Research, KUMS, and Iran.

Authors’ Contributions

ZA contributed in conception, data collection, and manuscript drafting. FB, MK, AS, and AE contributed in conception, data collection, and manuscript drafting. All authors read and approved the final version of the paper.

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Authors and Affiliations

  1. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran

    Fereshteh Bahmani, Mahsa Kia & Zatollah Asemi

  2. Department of Internal Medicine, Kashan University of Medical Sciences, Kashan, Iran

    Alireza Soleimani

  3. Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

    Ahmad Esmaillzadeh

  4. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran

    Ahmad Esmaillzadeh

  5. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

    Ahmad Esmaillzadeh

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  1. Fereshteh Bahmani
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  2. Mahsa Kia
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  4. Zatollah Asemi
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  5. Ahmad Esmaillzadeh
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Correspondence to Zatollah Asemi.

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The authors declare that they have no competing interests.

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ZA is the guarantor of this work.

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http://www.irct.ir.IRCT2015060622562N1

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Bahmani, F., Kia, M., Soleimani, A. et al. Effect of Selenium Supplementation on Glycemic Control and Lipid Profiles in Patients with Diabetic Nephropathy. Biol Trace Elem Res 172, 282–289 (2016). https://doi.org/10.1007/s12011-015-0600-4

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